A model for cellular development in morphogenetic fields

1992 ◽  
pp. 351-370 ◽  
Author(s):  
Martin J. M. de Boer ◽  
F. David Fracchia ◽  
Przemyslaw Prusinkiewicz
Keyword(s):  
Cellular Development ◽  
Morphogenetic Fields

scholarly journals CrossTORC and WNTegration in Disease: Focus on Lymphangioleiomyomatosis

2021 ◽  
Vol 22 (5) ◽  
pp. 2233
Author(s):  
Jilly Frances Evans ◽  
Kseniya Obraztsova ◽  
Susan M. Lin ◽  
Vera P. Krymskaya
Keyword(s):  
Integration Site ◽  
Cancer Development ◽  
Mechanistic Target Of Rapamycin ◽  
Complex Interactions ◽  
Signal Transduction Networks ◽  
Evolutionarily Conserved ◽  
Future Potential ◽  
Cellular Development ◽  
Wnt Signal ◽  
Disease Focus

The mechanistic target of rapamycin (mTOR) and wingless-related integration site (Wnt) signal transduction networks are evolutionarily conserved mammalian growth and cellular development networks. Most cells express many of the proteins in both pathways, and this review will briefly describe only the key proteins and their intra- and extracellular crosstalk. These complex interactions will be discussed in relation to cancer development, drug resistance, and stem cell exhaustion. This review will also highlight the tumor-suppressive tuberous sclerosis complex (TSC) mutated, mTOR-hyperactive lung disease of women, lymphangioleiomyomatosis (LAM). We will summarize recent advances in the targeting of these pathways by monotherapy or combination therapy, as well as future potential treatments.

Hepatic Cellular Development in the Rabbit

Neonatology ◽  
1981 ◽  
Vol 40 (3-4) ◽  
pp. 204-208 ◽  
Author(s):  
R.D.G. Milner ◽  
L. Pownall
Keyword(s):  
Cellular Development
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