Sickness Behavior: A Neuroimmune-Based Response to Infectious Disease

2000 ◽  
pp. 169-184 ◽  
Author(s):  
R. Dantzer ◽  
A. Aubert ◽  
R. M. Bluthe ◽  
J. R. Konsman ◽  
S. Laye ◽  
...  
Keyword(s):  
Infectious Disease ◽  
Sickness Behavior

Tissue section lifting for electron microscopy

1978 ◽  
Vol 36 (2) ◽  
pp. 86-87
Author(s):  
Adrian F. van Dellen
Keyword(s):  
Infectious Disease ◽  
Electron Microscopy ◽  
Tissue Culture ◽  
Organ System ◽  
Surrounding Tissue ◽  
Paraffin Sections ◽  
Surface Areas ◽  
Specific Determination ◽  
High Degree ◽  
Accuracy And Repeatability

The morphologic pathologist may require information on the ultrastructure of a non-specific lesion seen under the light microscope before he can make a specific determination. Such lesions, when caused by infectious disease agents, may be sparsely distributed in any organ system. Tissue culture systems, too, may only have widely dispersed foci suitable for ultrastructural study. In these situations, when only a few, small foci in large tissue areas are useful for electron microscopy, it is advantageous to employ a methodology which rapidly selects a single tissue focus that is expected to yield beneficial ultrastructural data from amongst the surrounding tissue. This is in essence what "LIFTING" accomplishes. We have developed LIFTING to a high degree of accuracy and repeatability utilizing the Microlift (Fig 1), and have successfully applied it to tissue culture monolayers, histologic paraffin sections, and tissue blocks with large surface areas that had been initially fixed for either light or electron microscopy.

Indian vultures: victims of an infectious disease epidemic?

2003 ◽  
Vol 6 (3) ◽  
pp. 189-197 ◽  
Author(s):  
A. A. Cunningham ◽  
V. Prakash ◽  
D. Pain ◽  
G. R. Ghalsasi ◽  
G. A. H. Wells ◽  
...  
Keyword(s):  
Infectious Disease

Experts List Top Articles in Infectious Disease

2006 ◽  
Vol 40 (2) ◽  
pp. 20
Author(s):  
SHERRY BOSCHERT
Keyword(s):  
Infectious Disease

Looking Ahead in Infectious Disease

2005 ◽  
Vol 39 (1) ◽  
pp. 10
Author(s):  
MARY ANNE JACKSON
Keyword(s):  
Infectious Disease

Top Findings in Pediatric Infectious Disease

2007 ◽  
Vol 41 (2) ◽  
pp. 13
Author(s):  
DIANA MAHONEY
Keyword(s):  
Infectious Disease ◽  
Pediatric Infectious Disease

AAP Updates Guidelines for Infectious Disease Exclusions

2009 ◽  
Vol 43 (2) ◽  
pp. 8
Author(s):  
DIANA MAHONEY
Keyword(s):  
Infectious Disease

Behavioral Testing of Mice Concerning Anxiety and Depression

2015 ◽  
Vol 223 (3) ◽  
pp. 151-156 ◽  
Author(s):  
Nina Schweinfurth ◽  
Undine E. Lang
Keyword(s):  
Environmental Influences ◽  
Sickness Behavior ◽  
Laboratory Research ◽  
Anxiety And Depression ◽  
Housing Conditions ◽  
Human Beings ◽  
Behavioral Testing ◽  
New Developments ◽  
Animal Trials ◽  
Resilience Factors

Abstract. In the development of new psychiatric drugs and the exploration of their efficacy, behavioral testing in mice has always shown to be an inevitable procedure. By studying the behavior of mice, diverse pathophysiological processes leading to depression, anxiety, and sickness behavior have been revealed. Moreover, laboratory research in animals increased at least the knowledge about the involvement of a multitude of genes in anxiety and depression. However, multiple new possibilities to study human behavior have been developed recently and improved and enable a direct acquisition of human epigenetic, imaging, and neurotransmission data on psychiatric pathologies. In human beings, the high influence of environmental and resilience factors gained scientific importance during the last years as the search for key genes in the development of affective and anxiety disorders has not been successful. However, environmental influences in human beings themselves might be better understood and controllable than in mice, where environmental influences might be as complex and subtle. The increasing possibilities in clinical research and the knowledge about the complexity of environmental influences and interferences in animal trials, which had been underestimated yet, question more and more to what extent findings from laboratory animal research translate to human conditions. However, new developments in behavioral testing of mice involve the animals’ welfare and show that housing conditions of laboratory mice can be markedly improved without affecting the standardization of results.

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