Correlation Between Cerebral Blood Flow Velocity in Basal Cerebral Arteries and Nimodipine Concentration in Serum and Plasma After Acute Subarachnoid Hemorrhage

Author(s):  
D. Rosenthal ◽  
M. Carvi y Nievas ◽  
W. I. Steudel ◽  
A. Ricco ◽  
R. Lorenz
2004 ◽  
Vol 1 (4) ◽  
pp. 455-460 ◽  
Author(s):  
Andreas R. Luft ◽  
Manuel M. Buitrago ◽  
Michel Torbey ◽  
Anish Bhardwaj ◽  
Alexander Razumovsky

Stroke ◽  
2013 ◽  
Vol 44 (suppl_1) ◽  
Author(s):  
David K Kung ◽  
Nohra Chalouhi ◽  
Pascal M Jabbour ◽  
Aaron S Dumont ◽  
H. R Winn ◽  
...  

Background: Head-of-bed (HOB) elevation is usually restricted in patients with aneurysmal subarachnoid hemorrhage (SAH). This practice is believed to prevent cerebral hypoperfusion. Objective: The goal of this study is to correlate HOB changes (0 o and 90 o ) with cerebral blood flow using Trans-cranial Doppler (TCD) and thermal diffusion probe in SAH patients. Methods: Thirteen patients with SAH were prospectively enrolled in the study. Eight patients underwent placement of a thermal diffusion probe for regional CBF measurement in the same setting when placing a ventriculostomy. CBF values were measured by TCD alone (13 subjects) or concurrently with thermal diffusion probe (8 subjects) with the patients in a flat (0 o ) and upright sitting position (90 o ) at day 3, 7, and 10. Results: The average increase in blood flow velocity when changing HOB from 0 o to 90 o was 7.8% on day 3, 0.1% on day 7, and 13.1% on day 10. The middle cerebral artery had the least changes in velocity compared to the anterior cerebral and the posterior cerebral arteries. The average regional CBF measurement was 22.7 +/- 10.3 ml/100g/min in the supine position and 23.6 +/- 9.1 mg/100g/min in the sitting position. The changes were not statistically significant. No change in clinical exam was appreciated. None of the patients developed clinical cerebral vasospasm. Conclusion: Changing HOB position in the setting of SAH did not significantly affect either cerebral blood flow velocity or regional blood flow. This data suggests that early mobilization should be considered given the detrimental effects of prolonged bed rest.


2021 ◽  
Vol 42 (4) ◽  
pp. 174-185
Author(s):  
Gyeong-muk Kim ◽  
Woo-Sang Jung ◽  
Seungwon Kwon ◽  
Chul Jin ◽  
Seung-Yeon Cho ◽  
...  

Objectives: The LI11 (Quchi) acupuncture point has always been included in the Seven acupoints for stroke; however, additional LI11 acupuncture research is needed. In this study, the effect of LI11 acupuncture on cerebral blood flow of the anterior cerebral arteries (ACA) and middle cerebral arteries (MCA) was investigated.Method: This study included 10 healthy young male subjects. Cerebral blood flow velocity and cerebrovascular reactivity were measured using transcranial Doppler sonography. Changes in hyperventilation-induced carbon dioxide (CO2) reactivity and modified ACA and MCA blood flow velocity at 40 mmHg (CV40), blood pressure, and heart rate were observed before and after LI11 acupuncture treatment.Results: A statistically significant increase in contralateral anterior cerebral artery CO2 reactivity (p=0.036) and decrease in contralateral middle cerebral artery CV40 (p=0.047) were observed. No significant difference in mean blood pressure was shown. A statistically significant increase in heart rate occurred after LI11 acupuncture; however, it was not clinically significant as there were negligible changes in the heart rhythm.Conclusions: LI11 acupuncture treatment could improve cerebral blood flow velocity. These results might be explained by regulating endothelium-dependent vessel dilation in the anterior cerebral artery region.Trial registration: This trial has been registered with Clinical Research Information Service, a service of the Korea Centers for Disease Control and Prevention: KCT0004494 (retrospectively registered). https://cris.nih.go.kr/cris/search/search_result_st01.jsp?seq=15359


Sign in / Sign up

Export Citation Format

Share Document