The open science movement enables the accessibility and reusability of research output across the globe. Researchers and other stakeholders in the research process can now easily collaborate to add to the body of knowledge. This chapter documents how open science is impacting the role of libraries, publishers, and authors in the digital era. A structured document analysis and web analysis were done to find out how authors, publishers, and librarians are affected by open science. It was found that librarians are taking advantage of open science to provide various information sources to patrons, the publishers are now charging article processing fees to make the journal articles open access upon publishing, and authors are now able to access many information sources during the research process and enjoy greater visibility of their research output. The author recommends the adoption of open science especially in the developing countries and the enactment of policies that support open science at national, regional, and international levels.