Folding of the mouse hepatitis virus spike protein and its association with the membrane protein

1994 ◽  
pp. 319-328 ◽  
Author(s):  
D.-J. E. Opstelten ◽  
P. Groote ◽  
M. C. Horzinek ◽  
P. J. M. Rottier
Keyword(s):  
Membrane Protein ◽  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Spike Protein

Coexpression and Association of the Spike Protein and the Membrane Protein of Mouse Hepatitis Virus

1995 ◽  
pp. 291-297
Author(s):  
Dirk-Jan E. Opstelten ◽  
Martin J. B. Raamsman ◽  
Karin Wolfs ◽  
Marian C. Horzinek ◽  
Peter J. M. Rottier
Keyword(s):  
Membrane Protein ◽  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Spike Protein

A Spike Protein-Dependent Cellular Factor Other Than the Viral Receptor Is Required for Mouse Hepatitis Virus Entry

Virology ◽  
1993 ◽  
Vol 196 (1) ◽  
pp. 45-56 ◽  
Author(s):  
Kyoko Yokomori ◽  
Miyuki Asanaka ◽  
Stephen A. Stohlman ◽  
Michael M.C. Lai
Keyword(s):  
Hepatitis Virus ◽  
Virus Entry ◽  
Mouse Hepatitis Virus ◽  
Spike Protein ◽  
Viral Receptor ◽  
Cellular Factor

scholarly journals Attachment of Mouse Hepatitis Virus to O-Acetylated Sialic Acid Is Mediated by Hemagglutinin-Esterase and Not by the Spike Protein

2010 ◽  
Vol 84 (17) ◽  
pp. 8970-8974 ◽  
Author(s):  
Martijn A. Langereis ◽  
Arno L. W. van Vliet ◽  
Willemijn Boot ◽  
Raoul J. de Groot
Keyword(s):  
Sialic Acid ◽  
Hepatitis Virus ◽  
Mouse Hepatitis Virus ◽  
Protein S ◽  
Sialic Acids ◽  
The Other ◽  
Spike Protein ◽  
Apparent Contrast ◽  
Group A ◽  
New Hosts

ABSTRACT The members of Betacoronavirus phylocluster A possess two types of surface projections, one comprised of the spike protein (S) and the other of hemagglutinin-esterase (HE). Purportedly, these viruses bind to O-acetylated sialic acids (O-Ac-Sias) primarily through S, with HE serving merely as receptor-destroying enzyme. Here, we show that, in apparent contrast to human and ungulate host range variants of Betacoronavirus-1, murine coronaviruses actually bind to O-Ac-Sias via HE exclusively. Apparently, expansion of group A betacoronaviruses into new hosts and niches was accompanied by changes in HE ligand and substrate preference and in the roles of HE and S in Sia receptor usage.

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