Biological Role of Matrix Metalloproteinases and the Endogenous Inhibitor Proteins in the Periprosthetic Connective Tissue Remodeling Around Loose Artificial Hip Joints

1999 ◽  
pp. 76-84
Author(s):  
Michiaki Takagi ◽  
Seppo Santavirta ◽  
Hideo Ida ◽  
Masaji Ishii ◽  
Iaso Takei ◽  
...  
Keyword(s):  
Matrix Metalloproteinases ◽  
Connective Tissue ◽  
Tissue Remodeling ◽  
Biological Role ◽  
Endogenous Inhibitor ◽  
Hip Joints ◽  
Artificial Hip ◽  
Artificial Hip Joints ◽  
Connective Tissue Remodeling

scholarly journals Synaptic activity and connective tissue remodeling in denervated frog muscle.

1994 ◽  
Vol 127 (5) ◽  
pp. 1435-1445 ◽  
Author(s):  
E A Connor ◽  
K Qin ◽  
H Yankelev ◽  
D DeStefano
Keyword(s):  
Skeletal Muscle ◽  
Extracellular Matrix ◽  
Connective Tissue ◽  
Muscle Activity ◽  
Tissue Remodeling ◽  
Interstitial Cells ◽  
Frog Muscle ◽  
Connective Tissue Remodeling ◽  
Denervated Frog Muscle

Denervation of skeletal muscle results in dramatic remodeling of the cellular and molecular composition of the muscle connective tissue. This remodeling is concentrated in muscle near neuromuscular junctions and involves the accumulation of interstitial cells and several extracellular matrix molecules. Given the role of extracellular matrix in neurite outgrowth and synaptogenesis, we predict that this remodeling of the junctional connective tissue directly influences the regeneration of the neuromuscular junction. As one step toward understanding the role of this denervation-induced remodeling in synapse formation, we have begun to look for the signals that are involved in initiating the junctional accumulations of interstitial cells and matrix molecules. Here, the role of muscle inactivity as a signal was examined. The distributions of interstitial cells, fibronectin, and tenascin were determined in muscles inactivated by presynaptic blockade of muscle activity with tetrodotoxin. We found that blockade of muscle activity for up to 4 wk produced neither the junctional accumulation of interstitial cells nor the junctional concentrations of tenascin and fibronectin normally present in denervated frog muscle. In contrast, the muscle inactivity induced the extrajunctional appearance of two synapse-specific molecules, the acetylcholine receptor and a muscle fiber antigen, mAb 3B6. These results demonstrate that the remodeling of the junctional connective tissue in response to nerve injury is a unique response of muscle to denervation in that it is initiated by a mechanism that is independent of muscle activity. Thus connective tissue remodeling in denervated skeletal muscle may be induced by signals released from or associated with the nerve other than the evoked release of neurotransmitter.

scholarly journals Fibroblast Matrix Gene Expression and Connective Tissue Remodeling: Role of Endothelin-1

2001 ◽  
Vol 116 (3) ◽  
pp. 417-425 ◽  
Author(s):  
Xu Shi-wen ◽  
Christopher P. Denton ◽  
Alan M. Holmes ◽  
Carol M. Black ◽  
David J. Abraham ◽  
...  
Keyword(s):  
Gene Expression ◽  
Connective Tissue ◽  
Tissue Remodeling ◽  
Endothelin 1 ◽  
Matrix Gene ◽  
Connective Tissue Remodeling

Markers of connective tissue remodeling in genital prolapse

GYNECOLOGY ◽  
2016 ◽  
Vol 18 (3) ◽  
Author(s):  
M.L Khanzadyan ◽  
V.E. Radzinskiy ◽  
T.A. Demura ◽  
A.V. Donnikov
Keyword(s):  
Connective Tissue ◽  
Tissue Remodeling ◽  
Genital Prolapse ◽  
Connective Tissue Remodeling

Comparative study of the wear of UHMWPE with zirconia ceramic and stainless steel femoral heads in artificial hip joints

1994 ◽  
Vol 16 (3) ◽  
pp. 229-236 ◽  
Author(s):  
B. Derbyshire ◽  
J. Fisher ◽  
D. Dowson ◽  
C. Hardaker ◽  
K. Brummitt
Keyword(s):  
Stainless Steel ◽  
Comparative Study ◽  
Zirconia Ceramic ◽  
Hip Joints ◽  
Artificial Hip ◽  
Femoral Heads ◽  
Artificial Hip Joints
Sign in / Sign up

Export Citation Format

Share Document