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2022 ◽  
Vol 146 ◽  
pp. 112588
Author(s):  
Ali Baradaran ◽  
Zahra Asadzadeh ◽  
Nima Hemmat ◽  
Amir Baghbanzadeh ◽  
Mahdi Abdoli Shadbad ◽  
...  

2022 ◽  
Vol 479 (1) ◽  
pp. 75-90
Author(s):  
Christina Ploumi ◽  
Margarita-Elena Papandreou ◽  
Nektarios Tavernarakis

Autophagy is a universal cellular homeostatic process, required for the clearance of dysfunctional macromolecules or organelles. This self-digestion mechanism modulates cell survival, either directly by targeting cell death players, or indirectly by maintaining cellular balance and bioenergetics. Nevertheless, under acute or accumulated stress, autophagy can also contribute to promote different modes of cell death, either through highly regulated signalling events, or in a more uncontrolled inflammatory manner. Conversely, apoptotic or necroptotic factors have also been implicated in the regulation of autophagy, while specific factors regulate both processes. Here, we survey both earlier and recent findings, highlighting the intricate interaction of autophagic and cell death pathways. We, Furthermore, discuss paradigms, where this cross-talk is disrupted, in the context of disease.


2022 ◽  
Vol 12 ◽  
Author(s):  
Farha Husain ◽  
Prerna Pathak ◽  
Elvira Román ◽  
Jesús Pla ◽  
Sneh Lata Panwar

Adaptation to ER stress is linked to the pathogenicity of C. albicans. The fungus responds to ER stress primarily by activating the conserved Ire1-Hac1-dependent unfolded protein response (UPR) pathway. Subsequently, when ER homeostasis is re-established, the UPR is attenuated in a timely manner, a facet that is unexplored in C. albicans. Here, we show that C. albicans licenses the HOG (high-osmolarity glycerol) MAPK pathway for abating ER stress as evidenced by activation and translocation of Hog1 to the nucleus during tunicamycin-induced ER stress. We find that, once activated, Hog1 attenuates the activity of Ire1-dependent UPR, thus facilitating adaptation to ER stress. We use the previously established assay, where the disappearance of the UPR-induced spliced HAC1 mRNA correlates with the re-establishment of ER homeostasis, to investigate attenuation of the UPR in C. albicans. hog1Δ/Δ cells retain spliced HAC1 mRNA levels for longer duration reflecting the delay in attenuating Ire1-dependent UPR. Conversely, compromising the expression of Ire1 (ire1 DX mutant strain) results in diminished levels of phosphorylated Hog1, restating the cross-talk between Ire1 and HOG pathways. Phosphorylation signal to Hog1 MAP kinase is relayed through Ssk1 in response to ER stress as inactivation of Ssk1 abrogates Hog1 phosphorylation in C. albicans. Additionally, Hog1 depends on its cytosolic as well as nuclear activity for mediating ER stress-specific responses in the fungus. Our results show that HOG pathway serves as a point of cross-talk with the UPR pathway, thus extending the role of this signaling pathway in promoting adaptation to ER stress in C. albicans. Additionally, this study integrates this MAPK pathway into the little known frame of ER stress adaptation pathways in C. albicans.


2022 ◽  
pp. 573-596
Author(s):  
Palak Bakshi ◽  
Sukhmeen Kaur Kohli ◽  
Shagun Bali ◽  
Parminder Kaur ◽  
Vinod Kumar ◽  
...  

2022 ◽  
Vol 18 (2) ◽  
pp. 783-799
Author(s):  
Luping Wang ◽  
Panxia Wang ◽  
Suowen Xu ◽  
Zhuoming Li ◽  
Dayue Darrel Duan ◽  
...  

2022 ◽  
pp. 41-59
Author(s):  
Afaf El-Ansary ◽  
Hanan Balto ◽  
Solaiman M. Al-Hadlaq
Keyword(s):  

2022 ◽  
pp. 15-32
Author(s):  
Anisuzzaman ◽  
Zobayda Farzana Haque ◽  
Muhammad Tofazzal Hossain
Keyword(s):  

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