Separation of Touching and Overlapped Human Chromosome Images

2015 ◽  
pp. 59-65 ◽  
Author(s):  
V. Sri Balaji ◽  
S. Vidhya
Keyword(s):  
Human Chromosome

On an Application of the Metallurgical Stage to Chromosome Morphology

1967 ◽  
Vol 25 ◽  
pp. 28-29
Author(s):  
Godfrey C. Hoskins
Keyword(s):  
Human Chromosome ◽  
Electron Micrographs ◽  
Chromosome Morphology ◽  
Electron Optics ◽  
Electron Micrograph ◽  
Photographic Evidence ◽  
Sophisticated Equipment ◽  
Periodic Arrangement

The first serious electron microscooic studies of chromosomes accompanied by pictures were by I. Elvers in 1941 and 1943. His prodigious study, from the manufacture of micronets to the development of procedures for interpreting electron micrographs has gone all but unnoticed. The application of todays sophisticated equipment confirms many of the findings he gleaned from interpretation of images distorted by the electron optics of that time. In his figure 18 he notes periodic arrangement of pepsin sensitive “prickles” now called secondary fibers. In his figure 66 precise regularity of arrangement of these fibers can be seen. In his figure 22 he reproduces Siegbahn's first stereoscopic electron micrograph of chromosomes.The two stereoscopic pairs of electron micrographs of a human chromosome presented here were taken with a metallurgical stage on a Phillips EM200. These views are interpreted as providing photographic evidence that primary fibers (1°F) about 1,200Å thick are surrounded by secondary fibers (2°F) arranged in regular intervals of about 2,800Å in this metanhase human chromosome. At the telomere the primary fibers bend back on themselves and entwine through the center of each of each chromatid. The secondary fibers are seen to continue to surround primary fibers at telomeres. Thus at telomeres, secondary fibers present a surface not unlike that of the side of the chromosome, and no more susceptible to the addition of broken elements from other chromosomes.

Localization of MODY3 to a 5-cM region of human chromosome 12

Diabetes ◽  
1995 ◽  
Vol 44 (12) ◽  
pp. 1408-1413 ◽  
Author(s):  
S. Menzel ◽  
K. Yamagata ◽  
J. B. Trabb ◽  
J. Nerup ◽  
M. A. Permutt ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Chromosome 12

Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20

Diabetes ◽  
1992 ◽  
Vol 41 (1) ◽  
pp. 88-92 ◽  
Author(s):  
D. W. Bowden ◽  
T. C. Gravius ◽  
G. Akots ◽  
S. S. Fajans
Keyword(s):  
Human Chromosome ◽  
Genetic Markers ◽  
Maturity Onset Diabetes ◽  
Chromosome 20 ◽  
Onset Diabetes

New susceptibility locus for NIDDM is localized to human chromosome 20q

Diabetes ◽  
1997 ◽  
Vol 46 (5) ◽  
pp. 876-881 ◽  
Author(s):  
L. Ji ◽  
M. Malecki ◽  
J. H. Warram ◽  
Y. Yang ◽  
S. S. Rich ◽  
...  
Keyword(s):  
Human Chromosome ◽  
Susceptibility Locus
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