Molecular Prognostic Markers in Colon Cancer

Author(s):  
Thomas Winder ◽  
Heinz-Josef Lenz
2019 ◽  
Vol 90 ◽  
pp. 70-79
Author(s):  
Matthew J. Cecchini ◽  
Joanna C. Walsh ◽  
Jeremy Parfitt ◽  
Subrata Chakrabarti ◽  
Rohann J. Correa ◽  
...  

Author(s):  
Junfeng Zhu ◽  
Ying Xu ◽  
Shanshan Liu ◽  
Li Qiao ◽  
Jianqiang Sun ◽  
...  

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Yingwei Jiao ◽  
Qiang Liu ◽  
Hongbo Zhao ◽  
Xianzhen Hu ◽  
Jinlong Sun ◽  
...  

Objective. Colon cancer (CC) shows a gradual increasing incidence in recent years, and chemotherapy is a frequently adopted treatment for patients with middle or advanced colon cancer (ACC), but it lacks prognostic markers after CC. Methods. The changes of lncRNA CASC9 in 58 patients with CC were determined using a real-time quantitative PCR (qRT-PCR) assay before and after chemotherapy, and the correlation of serum lncRNA CASC9 with efficacy of FOLFOX4 regimen (oxaliplatin + calcium folinate + fluorouracil) was analyzed. The patients were followed up to understand the association of lncRNA CASC9 with overall survival (OS) and progression-free survival (PFS). Results. Patients with CC showed notably higher lncRNA CASC9 expression than controls, and lncRNA CASC9 presented an association with the clinical stage of the patients. In addition, lncRNA CASC9 demonstrated a clinical value in predicting efficacy on patients and acted as one independent prognostic factor for PFS in patients with ACC. Conclusions. With increased expression of serum lncRNA CASC9, patients with ACC suffered an unfavorable chemotherapy effect. In addition, serum lncRNA CASC9 is a promising sensitive indicator for prediction of ACC and is related to the clinical efficacy and prognosis of patients.


BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Fee Klupp ◽  
Lena Neumann ◽  
Christoph Kahlert ◽  
Johannes Diers ◽  
Niels Halama ◽  
...  

2012 ◽  
pp. 131-162
Author(s):  
Janine M. Davies ◽  
Howard L. McLeod

2015 ◽  
Vol 26 (5) ◽  
pp. 386-391 ◽  
Author(s):  
Bala Basak Öven Ustaalioglu ◽  
Metin Tilki ◽  
Zeynep Gamze Kilicoglu ◽  
Ahmet Bilici ◽  
Ali Sürmelioglu

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