Prevention of graft rejection by cyclosporin A in man

Cyclosporin ◽  
1989 ◽  
pp. 112-144 ◽  
Author(s):  
Michael C. Jones ◽  
Graeme R. D. Catto
Keyword(s):  
Cyclosporin A ◽  
Graft Rejection

Efficacy and safety of microspheres of cyclosporin A, a new systemic formulation, to prevent corneal graft rejection in rats

2002 ◽  
Vol 24 (1) ◽  
pp. 39-45 ◽  
Author(s):  
Ana I. Vallelado ◽  
M. Isabel López ◽  
Margarita Calonge ◽  
Alejandro Sánchez ◽  
M. José Alonso
Keyword(s):  
Cyclosporin A ◽  
Graft Rejection ◽  
Corneal Graft ◽  
Efficacy And Safety ◽  
Corneal Graft Rejection

scholarly journals Corneal graft rejection: a new rabbit model and cyclosporin-A.

1982 ◽  
Vol 66 (5) ◽  
pp. 292-302 ◽  
Author(s):  
P A Hunter ◽  
A Garner ◽  
K R Wilhelmus ◽  
N S Rice ◽  
B R Jones
Keyword(s):  
Cyclosporin A ◽  
Graft Rejection ◽  
Rabbit Model ◽  
Corneal Graft ◽  
Corneal Graft Rejection

scholarly journals Effect of mycophenolate mofetil, cyclosporin A, and both in combination in a murine corneal graft rejection model

1998 ◽  
Vol 82 (6) ◽  
pp. 700-703 ◽  
Author(s):  
A. Reis ◽  
T. Reinhard ◽  
R. Sundmacher ◽  
C. Braunstein ◽  
E. Godehardt
Keyword(s):  
Mycophenolate Mofetil ◽  
Cyclosporin A ◽  
Graft Rejection ◽  
Corneal Graft ◽  
Corneal Graft Rejection

scholarly journals Cyclosporin-A abrogates transfusion-induced sensitization and prevents marrow graft rejection in DLA-identical canine littermates

Blood ◽  
1982 ◽  
Vol 60 (2) ◽  
pp. 524-526
Author(s):  
R Storb ◽  
HJ Deeg ◽  
K Atkinson ◽  
PL Weiden ◽  
G Sale ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Total Body Irradiation ◽  
Whole Blood ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Immunosuppressive Agent ◽  
Blood Transfusions ◽  
Marrow Graft ◽  
Short Course ◽  
Total Body

Previous studies had shown that marrow graft rejection generally did not occur in untransfused dogs given 900-rad total body irradiation and hemopoietic grafts from DLA identical littermates (only 1 of 59 rejected), but was seen in all instances after three preceding transfusions of whole blood from the marrow donor on days -24, -17, and -10 before transplantation (19 of 19 rejected). The present study was undertaken to investigate whether immunization by 3 preceding transfusions of whole blood from the DLA-identical littermate marrow donor could be abrogated by administration of the immunosuppressive agent cyclo-sporin-A, 20 mg/kg/day intramuscularly on days -5 to 0. Seven of 10 dogs showed sustained marrow engraftment. 2 failed to engraft, and 1 dog died to early to be evaluated. It was concluded that immunization to non-DLA antigens by preceding whole blood transfusions could be abrogated in most cases by a short-course of cyclosporin-A before total body irradiation and marrow transplantation, resulting in successful and sustained marrow engraftment.

scholarly journals Cyclosporin-A abrogates transfusion-induced sensitization and prevents marrow graft rejection in DLA-identical canine littermates

Blood ◽  
1982 ◽  
Vol 60 (2) ◽  
pp. 524-526 ◽  
Author(s):  
R Storb ◽  
HJ Deeg ◽  
K Atkinson ◽  
PL Weiden ◽  
G Sale ◽  
...  
Keyword(s):  
Cyclosporin A ◽  
Total Body Irradiation ◽  
Whole Blood ◽  
Graft Rejection ◽  
Marrow Transplantation ◽  
Immunosuppressive Agent ◽  
Blood Transfusions ◽  
Marrow Graft ◽  
Short Course ◽  
Total Body

Abstract Previous studies had shown that marrow graft rejection generally did not occur in untransfused dogs given 900-rad total body irradiation and hemopoietic grafts from DLA identical littermates (only 1 of 59 rejected), but was seen in all instances after three preceding transfusions of whole blood from the marrow donor on days -24, -17, and -10 before transplantation (19 of 19 rejected). The present study was undertaken to investigate whether immunization by 3 preceding transfusions of whole blood from the DLA-identical littermate marrow donor could be abrogated by administration of the immunosuppressive agent cyclo-sporin-A, 20 mg/kg/day intramuscularly on days -5 to 0. Seven of 10 dogs showed sustained marrow engraftment. 2 failed to engraft, and 1 dog died to early to be evaluated. It was concluded that immunization to non-DLA antigens by preceding whole blood transfusions could be abrogated in most cases by a short-course of cyclosporin-A before total body irradiation and marrow transplantation, resulting in successful and sustained marrow engraftment.

Effects of Topical Cyclosporin A on Human Corneal Graft Rejection

Cornea ◽  
1987 ◽  
Vol 6 (1) ◽  
pp. 62
Author(s):  
L. Goichot-Bonnat ◽  
Y. Pouliquen
Keyword(s):  
Cyclosporin A ◽  
Graft Rejection ◽  
Corneal Graft ◽  
Corneal Graft Rejection
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