New approach to peptide chain elongation in the N-C-direction in solid phase synthesis (‘inverse synthesis’)

Peptides 1994 ◽  
1995 ◽  
pp. 201-202 ◽  
Author(s):  
E. Bayer ◽  
B. Henkel ◽  
L. Zhang ◽  
N. Clausen ◽  
C. Goldammer ◽  
...  
1993 ◽  
Vol 58 (11) ◽  
pp. 2761-2765 ◽  
Author(s):  
Jan Hlaváček ◽  
Jana Pírková ◽  
Miroslava Žertová ◽  
Jan Pospíšek ◽  
Lenka Maletínská ◽  
...  

Using solid phase synthesis we prepared the cholecystokinin fragment Boc-CCK-7 (Boc-Tyr(SO3-Na+)-Met-Gly-Trp-Met-Asp-Phe-NH2) Ia and its seven analogues Ib - Ih. In the analogues Ib and Ic the Met residue in the carboxyterminal part of the molecule was substituted for L- or D-Phe Me3. In the analogues Id and Ie with Phe residue substituted by L- or D-Phe Me3 the Neo was inserted in the place of this Met residue and in the analogues If and Ig, an addition to PheMe3 substitution in the carboxyterminus, both Met residues were replaced for Neo. This dual substitution for Met residues was also applied in the analogue Ih with coded Phe residue in the C-terminus.


1998 ◽  
Vol 17 (8) ◽  
pp. 1347-1353 ◽  
Author(s):  
Janina Baraniak ◽  
Dariusz Korczyński ◽  
Renata Kaczmarek ◽  
Ewa Wasilewska

1998 ◽  
Vol 3 (3) ◽  
pp. 59-61
Author(s):  
Michal Lebl

High throughput solid phase synthesis can be performed with application of the centrifugation based liquid removal. This technique uses readily available standard microtiterplates and eliminates filtration step. It is therefore applicable to simultaneous processing of unlimited number of reaction compartments. Its use is illustrated on the synthesis of an array of 380 tetrahydroisoquinolinones.


Peptides 1990 ◽  
1991 ◽  
pp. 134-136 ◽  
Author(s):  
Fernando Albericio ◽  
Jordi Robles ◽  
Dolors Fernandez-Forner ◽  
Yolanda Palom ◽  
Carles Celma ◽  
...  

1996 ◽  
Vol 37 (20) ◽  
pp. 3571-3574 ◽  
Author(s):  
Dmitry A. Stetsenko ◽  
Elena N. Lubyako ◽  
Viktor K. Potapov ◽  
Tatyana L. Azhikima ◽  
Evgeny D. Sverdlov

2011 ◽  
Vol 78 (4) ◽  
pp. 603-611 ◽  
Author(s):  
Luisa F. Carreño ◽  
Martha P. Alba ◽  
Yahson Varela ◽  
Manuel E. Patarroyo ◽  
José Manuel Lozano

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