Abstract::
1,2,3-Triazole, a five-membered heterocyclic nucleus, is widely recognized as a key chromophore of great value in medicinal chemistry for delivering compounds possessing innumerable biological potentials encompassing antimicrobial, antitubercular, antidiabetic, antiviral, antitumor, antioxidants and anti-inflammatory. Particularly, in the past years, diverse conjugates carrying this biologically valuable core were reported owing to their attracting fungicidal potentials and their potent actions on diverse infective targets. Hence, hybridization of 1,2,3-triazole with other antimicrobial pharmacophores appears to be a judicious strategy to develop new efficacious anti-fungal candidates aiming at combating the emergence of drug-sensitive and drug-resistant infection disease. Thus, the current review highlights the recent advances of this promising category of 1,2,3-triazole-containing hybrids incorporating diverse varieties of bioactive heterocycles such as conozole, coumarin, imidazole, benzimidazole, pyrazole, indole, oxindole, chromene, pyrane, quinazoline, chalcone, isoflavone, car-bohydrates, amides. It underlies their inhibition behavior against different panels of infectious fungal species for the period during 2015-2020.
Recent advances in topical formulation carriers of antifungal agents