PET-CT in Pediatric Infection and Inflammation

Both 67Ga and 68Ga-citrates are used to detect a wide spectrum of pathology consisting of various inflammatory, infectious and malignant conditions. Considering the now widespread availability and constantly increasing demand for PET/CT studies,68Ga-citrate is gaining ground in clinical settings and the added value of combined metabolic and anatomical imaging achieved by combining PET with Computed Tomography (CT) to PET/CT makes 68Ga-citrate particularly promising. Despite the tracer's non-specificity, it has demonstrated potential especially in the evaluation of various infectious and inflammatory skeletal- and lung conditions. In this review, we will focus on the indications and lessons learned from 67Ga, and present the current status for the use of 68Ga-citrate PET/CT in selected inflammation and infectious diseases based on the limited literature available.

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PET-CT in Musculoskeletal Infection and Inflammation

PET-CT in Infection and Inflammation ◽

10.1007/978-981-15-9801-2_15 ◽

2020 ◽

pp. 209-227

Author(s):

Sikandar Shaikh

Keyword(s):

Musculoskeletal Infection ◽

Pet Ct ◽

Infection And Inflammation

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Monitoring of the Formation and Development Process for Infection and Inflammation Using F-18 FDG, PET/CT

Molecular Imaging and Radionuclide Therapy ◽

10.4274/mirt.24.01.08 ◽

2015 ◽

Vol 24 (1) ◽

pp. 41-41

Author(s):

Türkan Ertay ◽

Mine Sencan Eren ◽

Meral Karaman ◽

Gülgün Oktay ◽

Hatice Durak

Keyword(s):

Fdg Pet ◽

Development Process ◽

Pet Ct ◽

Infection And Inflammation ◽

Fdg Pet Ct

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Gallium-68 citrate PET/CT findings in an experimental model of acute appendicitis in rabbits

10.21203/rs.3.rs-16741/v1 ◽

2020 ◽

Author(s):

Aziz Gültekin ◽

Osman Uzunlu ◽

Ayşe Uğur ◽

Neşe Demirkan ◽

Esin Avcı ◽

...

Keyword(s):

Acute Appendicitis ◽

Sham Group ◽

Rabbit Model ◽

Experimental Models ◽

Automatic Synthesis ◽

Ct Findings ◽

Pet Ct ◽

Inflammation Imaging ◽

Infection And Inflammation ◽

Gallium 68

Abstract Objective Acute appendicitis (AA) is the most common abdominal surgical emergency worldwide. Several infection and inflammation imaging methods have been used in a limited number of cases. Gallium-68 ( 68 Ga) has recently been investigated as an infection and inflammation imaging agent. The aim of our study was to produce 68 Ga-citrate in an automated synthesis unit and perform 68 Ga-citrate PET/CT imaging in rabbits with experimentally induced AA. Furthermore, this study aimed to investigate and correlate PET/CT findings with those of histopathological and biochemical examinations. Methods 68 Ga-citrate was synthesized using the cationic method in an automatic synthesis unit. Twelve rabbits of the New Zealand strain ( Oryctolagus cuniculus ) were divided into two groups. In the AA group (n = 6), the appendices of the rabbits were surgically ligated. In the sham group (n = 6), the abdomen was surgically opened and closed. All rabbits were imaged using 68 Ga-citrate PET/CT at 12, 24 and 36 h following the establishment of the experimental models, and at 36 h, all rabbits were appendectomised. Appendices were examined histopathologically and blood samples were drawn from all rabbits at the beginning and end of the experimental process. Interleukin-6 (IL-6) and procalcitonin (Pct) levels were measured. PET/CT results were compared statistically with histopathological and biochemical references. Results The labelling efficiency of 68 Ga-citrate was more than 98%. The sensitivity, specificity and accuracy of 68 Ga-citrate PET/CT in AA were 100%, 83.3% and 81.7%, respectively. IL-6 and Pct levels at 36 h in the AA group were significantly higher than those in the sham group and at baseline (p < 0.05). Conclusions 68 Ga-citrate was synthesized in an automatic synthesis unit for the first time, and 68 Ga-citrate uptake was shown using PET/CT in a histopathologically and biochemically confirmed experimental AA rabbit model.

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