Stable adenine nucleotides inhibit [3H]-noradrenaline release in rabbit brain cortex slices by direct action at presynaptic adenosine A1-receptors

1992 ◽  
Vol 346 (2) ◽  
pp. 187-196 ◽  
Author(s):  
Ivar von Kügelgen ◽  
Leni Späth ◽  
Klaus Starke
Keyword(s):  
Noradrenaline Release ◽  
Brain Cortex ◽  
Adenine Nucleotides ◽  
Direct Action ◽  
Rabbit Brain ◽  
Adenosine A1 Receptors ◽  
Rabbit Brain Cortex ◽  
Adenosine A1 ◽  
Brain Cortex Slices ◽  
Cortex Slices

BIOCHEMICAL STUDIES ON TOFRANIL

1961 ◽  
Vol 39 (3) ◽  
pp. 551-558 ◽  
Author(s):  
P. N. Abadom ◽  
K. Ahmed ◽  
P. G. Scholefield
Keyword(s):  
Rat Brain ◽  
Rat Liver ◽  
Brain Cortex ◽  
Respiratory Activity ◽  
Liver Mitochondria ◽  
Brain Mitochondria ◽  
Inhibitory Effect ◽  
Rat Liver Mitochondria ◽  
Brain Cortex Slices ◽  
Cortex Slices

Tofranil inhibits the respiratory activity of rat brain cortex slices incubated in a glucose-containing medium. It also inhibits the uptake and incorporation of glycine-1-C14at concentrations which have only a slight inhibitory effect on the respiration of slices. Tofranil also inhibits oxidative phosphorylation in both rat liver and rat brain mitochondria but at higher concentrations respiration is greatly affected. Tofranil differs quantitatively from chlorpromazine in its greater inhibitory effect on the ATP–Pi32exchange reaction and its lesser effect on the cytochrome c oxidase activity of rat liver mitochondria.

Sign in / Sign up

Export Citation Format

Share Document