Potencies of antagonists chemically related to iodoproxyfan at histamine H3 receptors in mouse brain cortex and guinea-pig ileum: evidence for H3 receptor heterogeneity?

1996 ◽  
Vol 353 (5) ◽  
Author(s):  
E. Schlicker ◽  
M. Kathmann ◽  
H. Bitschnau ◽  
I. Marr ◽  
S. Reidemeister ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Mouse Brain ◽  
Brain Cortex ◽  
Guinea Pig Ileum ◽  
Histamine H3 Receptors ◽  
H3 Receptor ◽  
H3 Receptors ◽  
Mouse Brain Cortex ◽  
Histamine H3

Histamine H3-receptors inhibit neurogenic microvascular leakage in airways

1990 ◽  
Vol 68 (1) ◽  
pp. 21-25 ◽  
Author(s):  
M. Ichinose ◽  
M. G. Belvisi ◽  
P. J. Barnes
Keyword(s):  
Guinea Pig ◽  
Inhibitory Response ◽  
Sensory Nerves ◽  
Blue Dye ◽  
Dependent Manner ◽  
Histamine H3 Receptors ◽  
Microvascular Leakage ◽  
H3 Receptor ◽  
H3 Receptors ◽  
Histamine H3

We studied the role of histamine H3-receptors on neurogenic microvascular leakage in guinea pig airways by measuring extravasation of Evans blue dye. In guinea pig airways the major component of the neurogenic leakage is nonadrenergic noncholinergic (NANC) mediated, due to release of tachykinins. Anesthetized guinea pigs were pretreated with propranolol and atropine to block the beta-adrenergic and cholinergic responses and with mepyramine and cimetidine to block histamine H1- and H2-receptors, respectively. Vagal stimulation significantly increased leakage of dye in trachea (Tr), main bronchi (MB), and central (cIPA) and peripheral intrapulmonary airways (pIPA). The selective H3-receptor agonist (R)-alpha-methylhistamine (alpha-MeHA, 0.3-3 mg/kg iv) did not alter basal leakage but inhibited NANC-mediated leakage in a dose-dependent manner with a maximal inhibition of 56.9 (Tr, P less than 0.01), 66.7 (MB, P less than 0.01), 67.5 (cIPA, P less than 0.01), and 58.2% (pIPA, P less than 0.05) at 1 mg/kg. Pretreatment with phentolamine (2.5 mg/kg iv) had no effect on the inhibitory response produced by alpha-MeHA, but the H3-receptor antagonist thioperamide (5 mg/kg ip) blocked its effect. Exogenous substance P (1 microgram/kg iv) caused comparable plasma leakage to NANC-mediated response but was not inhibited by alpha-MeHA. We conclude that H3-agonists inhibit neurogenic leakage by prejunctional inhibition of neuropeptide release from airway sensory nerves.

Histamine H3 receptors in the guinea pig ileum: Evidence for a postjunctional location

2000 ◽  
Vol 94 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Giulio Bertaccini ◽  
Gabriella Morini ◽  
Giuseppina Coruzzi ◽  
Walter Schunack
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Ileum ◽  
Histamine H3 Receptors ◽  
H3 Receptors ◽  
Histamine H3

Histamine H3 receptors regulate acetylcholine release from the guinea pig ileum myenteric plexus

Life Sciences ◽  
1991 ◽  
Vol 48 (13) ◽  
pp. PL63-PL68 ◽  
Author(s):  
Enzo Poli ◽  
Gabriella Coruzzi ◽  
Giulio Bertaccini
Keyword(s):  
Guinea Pig ◽  
Myenteric Plexus ◽  
Acetylcholine Release ◽  
Guinea Pig Ileum ◽  
Histamine H3 Receptors ◽  
H3 Receptors ◽  
Histamine H3

Bronchodilator action of an agonist for histamine H3-receptors in guinea pig perfused bronchioles and lung parenchymal strips

Lung ◽  
1992 ◽  
Vol 170 (2) ◽  
Author(s):  
Jean-Luc Burgaud ◽  
James Javellaud ◽  
Nicole Oudart
Keyword(s):  
Guinea Pig ◽  
Histamine H3 Receptors ◽  
H3 Receptors ◽  
Histamine H3
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