Tissue compartments in laminae II?V of rabbit visual cortex ? three-dimensional arrangement, size and developmental changes

1996 ◽  
Vol 193 (1) ◽  
Author(s):  
Cordula Schmolke
Keyword(s):  
Visual Cortex ◽  
Three Dimensional ◽  
Developmental Changes ◽  
Tissue Compartments ◽  
Rabbit Visual Cortex

scholarly journals Morphological and Physiological Characterization of Layer VI Corticofugal Neurons of Mouse Primary Visual Cortex

2003 ◽  
Vol 89 (5) ◽  
pp. 2854-2867 ◽  
Author(s):  
Joshua C. Brumberg ◽  
Farid Hamzei-Sichani ◽  
Rafael Yuste
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Action Potentials ◽  
Three Dimensional ◽  
Cell Types ◽  
Dorsal Lateral Geniculate Nucleus ◽  
Morphological Properties ◽  
Feedback Connection ◽  
Physiological Characterization ◽  
Layer Vi

Layer VI is the origin of the massive feedback connection from the cortex to the thalamus, yet its complement of cell types and their connections is poorly understood. The physiological and morphological properties of corticofugal neurons of layer VI of mouse primary visual cortex were investigated in slices loaded with the Ca2+indicator fura-2AM. To identify corticofugal neurons, electrical stimulation of the white matter (WM) was done in conjunction with calcium imaging to detect neurons that responded with changes in intracellular Ca2+ concentrations in response to the stimulation. Subsequent whole cell recordings confirmed that they discharged antidromic action potentials after WM stimulation. Antidromically activated neurons were more excitable and had different spiking properties than neighboring nonantidromic neurons, although both groups had similar input resistances. Furthermore, antidromic neurons possessed narrower action potentials and smaller afterhyperpolarizations. Additionally, three-dimensional reconstructions indicated that antidromically activated neurons had a distinct morphology with longer apical dendrites and fewer nonprimary dendrites than nonantidromic cells. To identify the antidromic neurons, rhodamine microspheres were injected into the dorsal lateral geniculate nucleus of the thalamus and allowed to retrogradely transport back to the somata of the layer VI cortico-geniculate neurons. Physiological and anatomical analysis indicated that most antidromic neurons were likely to be cortico-geniculate neurons. Our results show that cortico-thalamic neurons represent a specific functional and morphological class of layer VI neurons.

The cells of origin of the corpus callosum in rabbit visual cortex

1978 ◽  
Vol 156 (1) ◽  
pp. 129-134 ◽  
Author(s):  
Harvey A. Swadlow ◽  
Theodore G. Weyand ◽  
Stephen G. Waxman
Keyword(s):  
Visual Cortex ◽  
Corpus Callosum ◽  
Cells Of Origin ◽  
Rabbit Visual Cortex

Mechanism of the "enhancing" response in the rabbit visual cortex

1971 ◽  
Vol 2 (1) ◽  
pp. 50-56
Author(s):  
A. Ya. Supin
Keyword(s):  
Visual Cortex ◽  
Rabbit Visual Cortex

scholarly journals Input-specific maturation of NMDAR-mediated transmission onto parvalbumin-expressing interneurons in layers 2/3 of the visual cortex

2018 ◽  
Vol 120 (6) ◽  
pp. 3063-3076 ◽  
Author(s):  
Camilo Ferrer ◽  
Helen Hsieh ◽  
Lonnie P. Wollmuth
Keyword(s):  
Visual Cortex ◽  
Critical Period ◽  
Pyramidal Neurons ◽  
Temporal Integration ◽  
Developmental Changes ◽  
Evoked Responses ◽  
Developmentally Regulated ◽  
Low Frequencies ◽  
Aspartate Receptor ◽  
Synaptic Responses

Parvalbumin-expressing (PV) GABAergic interneurons regulate local circuit dynamics. In terms of the excitation driving PV interneuron activity, the N-methyl-d-aspartate receptor (NMDAR)-mediated component onto PV interneurons tends to be smaller than that onto pyramidal neurons but makes a significant contribution to their physiology and development. In the visual cortex, PV interneurons mature during the critical period. We hypothesize that during the critical period, the NMDAR-mediated signaling and functional properties of glutamatergic synapses onto PV interneurons are developmentally regulated. We therefore compared the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)- and NMDAR-mediated synaptic responses before (postnatal days 15–20, P15–P20), during (P25–P40), and after (P50–P60) the visual critical period. AMPAR miniature excitatory postsynaptic currents (mEPSCs) showed a developmental decrease in frequency, whereas NMDAR mEPSCs were absent or showed extremely low frequencies throughout development. For evoked responses, we consistently saw a NMDAR-mediated component, suggesting pre- or postsynaptic differences between evoked and spontaneous neurotransmission. Evoked responses showed input-specific developmental changes. For intralaminar inputs, the NMDAR-mediated component significantly decreased with development. This resulted in adult intralaminar inputs almost exclusively mediated by AMPARs, suited for the computation of synaptic inputs with precise timing, and likely having NMDAR-independent forms of plasticity. In contrast, interlaminar inputs maintained a stable NMDAR-mediated component throughout development but had a shift in the AMPAR paired-pulse ratio from depression to facilitation. Adult interlaminar inputs with facilitating AMPAR responses and a substantial NMDAR component would favor temporal integration of synaptic responses and could be modulated by NMDAR-dependent forms of plasticity. NEW & NOTEWORTHY We show for the first time input-specific developmental changes in the N-methyl-d-aspartate receptor component and short-term plasticity of the excitatory drive onto layers 2/3 parvalbumin-expressing (PV) interneurons in the visual cortex during the critical period. These developmental changes would lead to functionally distinct adult intralaminar and interlaminar glutamatergic inputs that would engage PV interneuron-mediated inhibition differently.

scholarly journals Mixed-polarity random-dot stereograms alter GABA and Glx concentration in the early visual cortex

2019 ◽  
Author(s):  
Reuben Rideaux ◽  
Nuno Goncalves ◽  
Andrew E Welchman
Keyword(s):  
Visual Cortex ◽  
Three Dimensional ◽  
Theoretical Work ◽  
Dimensional Structure ◽  
Resonance Spectroscopy ◽  
Gaba Concentration ◽  
Recent Theoretical Work ◽  
Random Dot Stereograms ◽  
Mixed Polarity ◽  
Early Visual Cortex

ABSTRACTThe offset between images projected onto the left and right retinae (binocular disparity) provides a powerful cue to the three-dimensional structure of the environment. It was previously shown that depth judgements are better when images comprise both light and dark features, rather than only dark or only light elements. Since Harris and Parker (1995) discovered the “mixed-polarity benefit”, there has been limited evidence supporting their hypothesis that the benefit is due to separate bright and dark channels. Goncalves and Welchman (2017) observed that single- and mixed-polarity stereograms evoke different levels of positive and negative activity in a deep neural network trained on natural images to make depth judgements, which also showed the mixed-polarity benefit. Motivated by this discovery, here we seek to test the potential for changes in the balance of excitation and inhibition that are produced by viewing these stimuli. In particular, we use magnetic resonance spectroscopy to measure Glx and GABA concentration in the early visual cortex of adult humans while viewing single- and mixed-polarity random-dot stereograms (RDS). We find that observers’ Glx concentration is significantly higher while GABA concentration is significantly lower when viewing mixed-polarity RDS than when viewing single-polarity RDS. These results indicate that excitation and inhibition facilitate processing of single- and mixed-polarity stereograms in the early visual cortex to different extents, consistent with recent theoretical work (Goncalves & Welchman, 2017).

Habituation in the rabbit visual cortex during development and after septal ablation

1973 ◽  
Vol 4 (2) ◽  
pp. 91-96
Author(s):  
A. G. Koreli
Keyword(s):  
Visual Cortex ◽  
Rabbit Visual Cortex

scholarly journals Disparity processing in primary visual cortex

2016 ◽  
Vol 371 (1697) ◽  
pp. 20150255 ◽  
Author(s):  
Sid Henriksen ◽  
Seiji Tanabe ◽  
Bruce Cumming
Keyword(s):  
Visual Cortex ◽  
Primary Visual Cortex ◽  
Striate Cortex ◽  
Three Dimensional ◽  
Empirical Support ◽  
Energy Model ◽  
Correspondence Problem ◽  
Stereo Correspondence ◽  
V1 Neurons ◽  
The Right

The first step in binocular stereopsis is to match features on the left retina with the correct features on the right retina, discarding ‘false’ matches. The physiological processing of these signals starts in the primary visual cortex, where the binocular energy model has been a powerful framework for understanding the underlying computation. For this reason, it is often used when thinking about how binocular matching might be performed beyond striate cortex. But this step depends critically on the accuracy of the model, and real V1 neurons show several properties that suggest they may be less sensitive to false matches than the energy model predicts. Several recent studies provide empirical support for an extended version of the energy model, in which the same principles are used, but the responses of single neurons are described as the sum of several subunits, each of which follows the principles of the energy model. These studies have significantly improved our understanding of the role played by striate cortex in the stereo correspondence problem. This article is part of the themed issue ‘Vision in our three-dimensional world’.

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