Identification of separate vasopressin-neurophysin II and oxytocin-neurophysin I containing nerve fibres in the external region of the bovine median eminence

1975 ◽  
Vol 158 (4) ◽  
pp. 509-516 ◽  
Author(s):  
F. Vandesande ◽  
K. Dierickx ◽  
J. De Mey
1977 ◽  
Vol 180 (4) ◽  
pp. 443-452 ◽  
Author(s):  
F. Vandesande ◽  
K. Dierickx ◽  
J. De Mey

1970 ◽  
Vol 64 (4) ◽  
pp. 696-704 ◽  
Author(s):  
Peter M. Daniel ◽  
Marjorie M. L. Prichard

ABSTRACT In goats kept for several months after hypophysectomy it was found that the nerve fibres of the hypothalamo-neurohypophysial tract had regenerated. A posterior lobe-like organ had formed in the neural tissue of the median eminence just proximal to the site where the nerve tract had been severed when the pituitary gland was removed. This new, small, ectopic infundibular process was not only well innervated but also highly vascularised and it contained large amounts of neurosecretory material. Some of the regenerating nerve fibres had grown out from the nerve tract into pars tuberalis and the meninges; many of these nerve fibres carried neurosecretory material. In one goat, not hypophysectomized but with a traumatic lesion of the nerve tract in the pituitary stalk, regenerating nerve fibres had also grown down across the scar of the lesion to reinnervate the degenerate distal part of the nerve tract. Within the hypothalamus the loss of nerve cells was consistently greater in the supraoptic than in the paraventricular nuclei.


1979 ◽  
Vol 204 (1) ◽  
pp. 29-36 ◽  
Author(s):  
J. van Vossel-Daeninck ◽  
K. Dierickx ◽  
A. van Vossel ◽  
F. Vandesande

1953 ◽  
Vol 9 (1) ◽  
pp. 30-41 ◽  
Author(s):  
E. VAZQUEZ-LOPEZ

1. The rabbit neurohypophysis is composed of nerve fibres and their endings, of neuroglia and microglia, and of a vascular system with reticulin fibres spreading in perivascular spaces. 2. The nerve tracts in the pars nervosa lie in the wide areas between the perivascular spaces, but the axons leave the tracts to run their terminal courses within these spaces. 3. The axons terminate in complicated giant bulbs and menisci. 4. The neuroglia lies in the same areas as the nerve tracts. Many neuroglial processes cross the perivascular spaces and end in attachment to the vessel wall. There are no important connexions between neuroglial cells and axon endings. 5. There is no specific type of neuroglia peculiar to the neurohypophysis. The morphology of the neuroglial cells in the median eminence and in the stalk is different from that of the neuroglial cells in the pars nervosa. 6. Morphologically, the neurohypophysis appears to be a sensory organ, similar to the chemo-receptors and pressor-receptors existing in other parts of the body. If it has a secretory function as well, then the secretion may occur at the giant terminations of the nerves, perhaps by a process of rupture of these formations.


1979 ◽  
Vol 83 (2) ◽  
pp. 165-173 ◽  
Author(s):  
G. B. MAKARA ◽  
E. STARK ◽  
G. RAPPAY ◽  
M. KÁRTESZI ◽  
M. PALKOVITS

The activity of corticotrophin releasing factor (CRF) in extracts of the stalk median eminence (SME) complex proper (average protein content, 30·6 μg) of male rats was assayed by monolayer cultures of anterior pituitary cells using the release of immunoreactive ACTH. Extracts which were equivalent to 0·025 SME of control rats usually had detectable CRF activity, while there was no detectable activity in extracts of 0·4 SME equiv. taken 8 days after complete surgical isolation of the medial basal hypothalamus (MBH). The activity of CRF in extracts from rats with an anterolateral cut around the MBH was at least ten times less than that in the control rats. One day after placing an anterolateral cut around the MBH the ACTH releasing activity of the SME was not significantly different from that of the control animals but activity decreased significantly 3 days after the operation and was at least ten times less than in the control animals on day 7 after the operation. It is suggested that most of the CRF activity of the SME is contained in nerve fibres entering the neurohaemal region from outside the MBH and that transection of these fibres produced the fall in CRF content of the SME in rats with partial or total surgical isolation of the MBH.


Author(s):  
K.A. Carson ◽  
C.B. Nemeroff ◽  
M.S. Rone ◽  
J.S. Kizer ◽  
J.S. Hanker

Biochemical, physiological, pharmacological, and more recently enzyme histo- chemical data have indicated that cholinergic circuits exist in the hypothalamus. Ultrastructural correlates of these pathways such as acetylcholinesterase (AchE) positive neurons in the arcuate nucleus (ARC) and stained terminals in the median eminence (ME) have yet to be described. Initial studies in our laboratories utilizing chemical lesioning and microdissection techniques coupled with microchemical and light microscopic enzyme histo- chemical studies suggested the existence of cholinergic neurons in the ARC which project to the ME (1). Furthermore, in adult male rats with Halasz deafferentations (hypothalamic islands composed primarily of the isolated ARC and the ME) choline acetyltransferase (ChAc) activity, a good marker for cholinergic neurons, was not significantly reduced in the ME and was only somewhat reduced in the ARC (2). Treatment of neonatal rats with high doses of monosodium 1-glutamate (MSG) results in a lesion largely restricted to the neurons of the ARC.


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