Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine

DanielS. Martin; RobertL. Stolfi; RobertC. Sawyer

doi:10.1007/bf00254098

Use of oral uridine as a substitute for parenteral uridine rescue of 5-fluorouracil therapy, with and without the uridine phosphorylase inhibitor 5-benzylacyclouridine

Cancer Chemotherapy and Pharmacology ◽

10.1007/bf00254098 ◽

1989 ◽

Vol 24 (1) ◽

Cited By ~ 41

Author(s):

DanielS. Martin ◽

RobertL. Stolfi ◽

RobertC. Sawyer

Keyword(s):

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor

Cancer Chemotherapy and Pharmacology ◽

10.1007/s00280-006-0213-x ◽

2006 ◽

Vol 58 (5) ◽

pp. 692-698 ◽

Cited By ~ 9

Author(s):

Omar N. Al Safarjalani ◽

Reem Rais ◽

Junxing Shi ◽

Raymond F. Schinazi ◽

Fardos N. M. Naguib ◽

...

Keyword(s):

Human Colon ◽

Uridine Phosphorylase ◽

Colon Tumors ◽

Chemotherapeutic Efficacy ◽

Uridine Phosphorylase Inhibitor

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Modified 5-fluorouracil: Uridine phosphorylase inhibitor

Crystallography Reports ◽

10.1134/s1063774516050138 ◽

2016 ◽

Vol 61 (5) ◽

pp. 826-829 ◽

Cited By ~ 2

Author(s):

A. A. Lashkov ◽

A. A. Shchekotikhin ◽

A. A. Shtil ◽

S. E. Sotnichenko ◽

A. M. Mikhailov

Keyword(s):

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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5-(m-Benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-o-acetyluridine, a prodrug of uridine, as modulators of plasma uridine concentration

Biochemical Pharmacology ◽

10.1016/0006-2952(96)00102-5 ◽

1996 ◽

Vol 51 (12) ◽

pp. 1601-1611 ◽

Cited By ~ 14

Author(s):

Osama M. Ashour ◽

Fardos N.M. Naguib ◽

Mahmoud H. el Kouni

Keyword(s):

Barbituric Acid ◽

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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Enhancement of the bioavailability of oral uridine by coadministration of 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for uridine rescue regimens in chemotherapy

Cancer Chemotherapy and Pharmacology ◽

10.1007/s002800100353 ◽

2001 ◽

Vol 48 (5) ◽

pp. 389-397 ◽

Cited By ~ 8

Author(s):

Omar N. Safarjalani ◽

Xiao-Jian Zhou ◽

Fardos N. Naguib ◽

Junxing Shi ◽

Raymond F. Schinazi ◽

...

Keyword(s):

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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A new Method for the Synthesis of 5-Benzyl-1-(2-Hydroxyethoxy Methyl)Uracil (Bau), A Potent Uridine Phosphorylase Inhibitor, And Its N3-And N1, N3, -Substituted Analogs

Synthetic Communications ◽

10.1080/00397918808060877 ◽

1988 ◽

Vol 18 (9) ◽

pp. 931-936 ◽

Cited By ~ 2

Author(s):

Tai-Shun Lin ◽

Mao-Chin Liu

Keyword(s):

New Method ◽

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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19F NMR monitoring ofin vivo tumor metabolism after biochemical modulation of 5-fluorouracil by the uridine phosphorylase inhibitor 5-benzylacyclouridine

Magnetic Resonance in Medicine ◽

10.1002/mrm.1910380609 ◽

1997 ◽

Vol 38 (6) ◽

pp. 907-916 ◽

Cited By ~ 16

Author(s):

Scott K. Holland ◽

Andries M. Bergman ◽

Yiming Zhao ◽

Earle R. Adams ◽

Giuseppe Pizzorno

Keyword(s):

Tumor Metabolism ◽

19F Nmr ◽

Biochemical Modulation ◽

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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Differential effects of 2,2'-anhydro-5-ethyluridine, a uridine phosphorylase inhibitor, on the antitumor activity of 5-fluorouridine and 5-fluoro-2'-deoxyuridine

Biochemical Pharmacology ◽

10.1016/0006-2952(90)90270-u ◽

1990 ◽

Vol 39 (7) ◽

pp. 1247-1253 ◽

Cited By ~ 16

Author(s):

Iigo Masaaki ◽

Nishikata Ken-Ichi ◽

Nakajima Yoko ◽

Szinai Istvan ◽

Veres Zsuzsa ◽

...

Keyword(s):

Antitumor Activity ◽

Uridine Phosphorylase ◽

Differential Effects ◽

Uridine Phosphorylase Inhibitor

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Modulation of 5-fluorouracil host toxicity by 5-(benzyloxybenzyl)barbituric acid acyclonucleoside, a uridine phosphorylase inhibitor, and 2′,3′,5′-tri-O-acetyluridine, a prodrug of uridine

Biochemical Pharmacology ◽

10.1016/s0006-2952(00)00342-7 ◽

2000 ◽

Vol 60 (3) ◽

pp. 427-431 ◽

Cited By ~ 11

Author(s):

Osama M Ashour ◽

Fardos N.M Naguib ◽

Raymond P Panzica ◽

Omar N Al Safarjalani ◽

Mahmoud H el Kouni

Keyword(s):

Barbituric Acid ◽

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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Modulation of the pharmacokinetics of endogenous plasma uridine by 5-(phenylthio)acyclouridine, a uridine phosphorylase inhibitor: implications for chemotherapy

Cancer Chemotherapy and Pharmacology ◽

10.1007/s002800100292 ◽

2001 ◽

Vol 48 (2) ◽

pp. 145-150 ◽

Cited By ~ 3

Author(s):

Omar Al Safarjalani ◽

Xiao-Jian Zhou ◽

Fardos Naguib ◽

Naganna Goudgaon ◽

Raymond Schinazi ◽

...

Keyword(s):

Uridine Phosphorylase ◽

Uridine Phosphorylase Inhibitor

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P53 Regulation of Uridine Phosphorylase Activity Pyrimidine Salvage Pathway and Their Effects on Breast Cancer Therapy

10.21236/ada395919 ◽

2001 ◽

Author(s):

Deliang Cao ◽

Giuseppe Pizzorno

Keyword(s):

Breast Cancer ◽

Cancer Therapy ◽

Uridine Phosphorylase ◽

Salvage Pathway ◽

Phosphorylase Activity ◽

Breast Cancer Therapy ◽

Pyrimidine Salvage

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