DNA restriction mapping identifies the chromosome carrying the mutant Hb Presbyterian ?-globin gene

1983 ◽  
Vol 64 (3) ◽  
pp. 263-266 ◽  
Author(s):  
J. Horst ◽  
Renate Oehme ◽  
E. Kleihauer ◽  
Elisabeth Kohne
Keyword(s):  
Globin Gene ◽  
Restriction Mapping ◽  
Dna Restriction

Expectation and Variance of True and False Fragment Matches in DNA Restriction Mapping

1998 ◽  
Vol 5 (1) ◽  
pp. 101-111 ◽  
Author(s):  
ANDREW F. SIEGEL ◽  
JARED C. ROACH ◽  
GER VAN DEN ENGH
Keyword(s):  
Restriction Mapping ◽  
Dna Restriction

scholarly journals Multiple solutions of DNA restriction mapping problems

1991 ◽  
Vol 12 (4) ◽  
pp. 412-427 ◽  
Author(s):  
William Schmitt ◽  
Michael S Waterman
Keyword(s):  
Multiple Solutions ◽  
Restriction Mapping ◽  
Dna Restriction

Correlation of Mitochondrial DNA Restriction Endonuclease Patterns with Sterility Expression in Six Male‐Sterile Sorghum Cytoplasms 1

Crop Science ◽  
1982 ◽  
Vol 22 (3) ◽  
pp. 536-539 ◽  
Author(s):  
M. F. Conde ◽  
D. R. Pring ◽  
K. F. Schertz ◽  
W. M. Ross
Keyword(s):  
Mitochondrial Dna ◽  
Restriction Endonuclease ◽  
Male Sterile ◽  
Dna Restriction ◽  
Restriction Endonuclease Patterns

scholarly journals In silico prediction of HBD gene variants in the Iranian population

2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Keivan Moradi ◽  
Aboozar Mohammadi ◽  
Mohsen Kazeminia
Keyword(s):  
Persian Gulf ◽  
Globin Gene ◽  
Iranian Population ◽  
Gene Variants ◽  
In Silico Prediction ◽  
Screening Programs ◽  
Prediction Tools ◽  
Clinical Laboratories ◽  
The Persian Gulf ◽  
Thalassemia Screening

Abstract Background The quantification of hemoglobin A2 (Hb A2; α2δ2) is used as a valuable test to differentiate α- and ß-thal carriers in clinical laboratories. Therefore, the HBD (δ-globin) gene variants could result in reduced levels of Hb A2 and have implications for thalassemia screening programs. The aim of the present study was to predict the consequences of HBD gene variants identified in the Iranome project. Results The highest number of variants was in the Persian Gulf Islanders. The variants of p.Gln132Glu (HBD: c.394C>G), p.Gly17Arg (HBD: c.49G>C), p.Thr5Ile (HBD: c.14C>T), and p.Ala28Ser (HBD: c.82G>T) presented damage results in three or more prediction tools. In addition, it seems that the p.Gly30= (HBD: c.90C>T) decreases the use of authentic splice and, instead, creates a new donor splice site (DSS) or leads to the use of a cryptic DSS. Conclusions Most of these variants have been associated with a decrease in Hb A2 levels. Due to the high mutational diversity in the HBB gene in the Iranian population and the use of Hb A2 quantification to differentiate α- and ß-thal carriers among Iranian clinical laboratories, some attention should be taken to a possible co-inheritance of HBD gene variants to avoid the misdiagnosis of ß-thal carriers.

scholarly journals Hemin controls the expression of the beta minor globin gene in Friend erythroleukemic cells at the pretranslational level

1978 ◽  
Vol 253 (21) ◽  
pp. 7588-7590
Author(s):  
G. Rovera ◽  
J. Vartikar ◽  
G.R. Connolly ◽  
C. Magarian ◽  
T.W. Dolby
Keyword(s):  
Globin Gene ◽  
Friend Erythroleukemic Cells ◽  
Erythroleukemic Cells

Rapid and reliable β-globin gene cluster haplotyping of sickle cell disease patients by FRET Light Cycler and HRM assays

2011 ◽  
Vol 412 (13-14) ◽  
pp. 1257-1261 ◽  
Author(s):  
Philippe Joly ◽  
Philippe Lacan ◽  
Caroline Garcia ◽  
Angelique Delasaux ◽  
Alain Francina
Keyword(s):  
Sickle Cell Disease ◽  
Gene Cluster ◽  
Sickle Cell ◽  
Globin Gene ◽  
Cell Disease ◽  
Globin Gene Cluster ◽  
Light Cycler
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