A prospective, double-blind, randomized study of high-versus low-dose OKT3 induction immunosuppression in cadaveric renal transplantation

1994 ◽  
Vol 7 (5) ◽  
pp. 356-361 ◽  
Author(s):  
Douglas J. Norman ◽  
Jess A. Kimball ◽  
William M. Bennett ◽  
Fuad Shihab ◽  
Thomas D. Batiuk ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Low Dose ◽  
Randomized Study ◽  
Double Blind ◽  
Cadaveric Renal Transplantation

A prospective, double-blind, randomized study of high-versus low-dose OK3 induction immunosuppression in cadaveric renal transplantation

1994 ◽  
Vol 7 (5) ◽  
pp. 356-361
Author(s):  
Douglas J. Norman ◽  
Jess A. Kimball ◽  
William M. Bennett ◽  
Fuad Shihab ◽  
Thomas D. Batiuk ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Low Dose ◽  
Randomized Study ◽  
Double Blind ◽  
Cadaveric Renal Transplantation

A Double-Blind, Randomized Study of Extended-Release Molindone for Impulsive Aggression in ADHD

2020 ◽  
pp. 108705472090908 ◽  
Author(s):  
Gianpiera Ceresoli-Borroni ◽  
Azmi Nasser ◽  
Toyin Adewole ◽  
Tesfaye Liranso ◽  
Jiahong Xu ◽  
...  
Keyword(s):  
Extended Release ◽  
Low Dose ◽  
Behavioral Therapy ◽  
Randomized Study ◽  
High Dose ◽  
Double Blind ◽  
Impulsive Aggression ◽  
Pediatric Populations ◽  
Dose Ranging ◽  
Medium Dose

Objective: To evaluate efficacy and safety of SPN-810 (extended-release molindone) in a Phase-2b, randomized, double-blind, placebo-controlled, dose-ranging study of children (6–12 years) with ADHD and persistent impulsive aggression (IA). Method: After lead-in, children were randomized to (a) placebo ( N = 31); (b) low-dose ( N = 29, 12/18 mg/day); (c) medium-dose ( N = 30, 24/36 mg/day); and (4) high-dose ( N = 31, 36/54 mg/day) groups. Treatment included ~2.5-week titration, 3-week maintenance, and 1-week tapering/conversion, alongside existing monotherapy (stimulants/nonstimulants) and behavioral therapy. The primary endpoint was change in Retrospective-Modified Overt Aggression Scale (R-MOAS) score at end of study, with safety monitored. Results: A total of 95 (78.5%) children completed the study. Aggression (R-MOAS) improved with low and medium doses (low dose: p = .031; medium dose: p = .024; high dose: p = .740). The most common adverse events were headache (10.0%), sedation (8.9%), and increased appetite (7.8%). Conclusion: These results suggest SPN-810 may be effective in reducing residual IA behaviors in children with ADHD. Research is still needed to support the benefit–risk profile of SPN-810 in pediatric populations.

scholarly journals A PROSPECTIVE RANDOMIZED TRIAL OF LOW-DOSE VERSUS HIGH-DOSE STEROIDS IN CADAVERIC RENAL TRANSPLANTATION

1984 ◽  
Vol 37 (4) ◽  
pp. 373-377 ◽  
Author(s):  
A. J. F. DCARAPICE ◽  
G. J. BECKER ◽  
P. KINCAID-SMITH ◽  
T. H. MATHEW ◽  
J. NG ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Randomized Trial ◽  
Low Dose ◽  
Prospective Randomized Trial ◽  
High Dose ◽  
Cadaveric Renal Transplantation

Cyclosporin a used alone or in combination with low-dose steroids in cadaveric renal transplantation

1983 ◽  
Vol 61 (20) ◽  
pp. 991-1000 ◽  
Author(s):  
G. Thiel ◽  
F. Harder ◽  
R. L�rtscher ◽  
M. Br�nisholz ◽  
J. Landmann ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Cyclosporin A ◽  
Low Dose ◽  
Cadaveric Renal Transplantation

LOW-DOSE CYCLOSPORINE FOR CADAVERIC RENAL TRANSPLANTATION

1988 ◽  
Vol 45 (2) ◽  
pp. 320-322 ◽  
Author(s):  
Ben A. Vanderwerf ◽  
Arnold I. Serota
Keyword(s):  
Renal Transplantation ◽  
Low Dose ◽  
Cadaveric Renal Transplantation

scholarly journals Randomized study with cyclosporine in kidney transplantation: 10-year follow-up.

1996 ◽  
Vol 7 (5) ◽  
pp. 792-797
Author(s):  
C Ponticelli ◽  
G Civati ◽  
A Tarantino ◽  
F Quarto di Palo ◽  
G Corbetta ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Graft Survival ◽  
Controlled Trial ◽  
Randomized Study ◽  
Graft Function ◽  
Rank Test ◽  
Cadaveric Renal Transplantation ◽  
Azathioprine Group

This study presents the 10-yr follow-up results of a multicenter controlled trial on 108 recipients of cadaveric renal transplantation, randomized to receive cyclosporine (N = 55) or azathioprine (N = 53), both in combination with steroids. The 10-yr patient survival rate was 89% in the cyclosporine group and 83% in the azathioprine group (P = not significant [NS]); the 10-yr graft survival was 56% and 35%, respectively (log-rank test, P = 0.009). The half-life of grafts functioning after 1 yr was 15.4 +/- 3.9 versus 10.6 +/- 3.6, P = NS). The rate of early rejection in the cyclosporine group was significantly lower than that in the azathioprine group (0.30 versus 1.4, P < 0.01). Although the mean creatinine clearance rate was always higher in the azathioprine group, the decline in graft function from the first to the tenth yr was not significantly different between the two groups (-13.0 +/- 16.4 versus -12.3 +/- 19 mL/min, P = NS). In cadaveric renal transplantation, cyclosporine allows better graft survival than azathioprine, not only in the short term but also in the long term, with similar attrition of graft function for up to 10 yr.

scholarly journals Low-dose tacrolimus combined with donor-derived mesenchymal stem cells after renal transplantation: a prospective, non-randomized study

Oncotarget ◽  
2016 ◽  
Vol 7 (11) ◽  
pp. 12089-12101 ◽  
Author(s):  
Guang-hui Pan ◽  
Zheng Chen ◽  
Lu Xu ◽  
Jing-hui Zhu ◽  
Peng Xiang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Renal Transplantation ◽  
Low Dose ◽  
Randomized Study
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