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2021 ◽  
Vol 6 (2) ◽  
pp. 202
Author(s):  
Mardi Lestari ◽  
Nurul Fitriah Aras ◽  
Nur Fauziah ◽  
Andi Wahyu Irawan ◽  
Muhammad Junaedi Mahyuddin

Permasalahan utama penelitian ini adalah kebiasaan bermain game online oleh siswa di rumah. Tujuan utama penelitian ini adalah menjelaskan efektivitas layanan konseling kelompok kontrak perilaku untuk mengurangi perilaku bermain game online di rumah. Penelitian ini menggunakan jenis penelitian kuantitatif dengan model One Grup Pretest-Posttes Design. Sampel penelitian ini menggunakan metode purposive sampling sebanyak 6 orang siswa SMP Negeri 15 Palu. Data hasil angket analisis dengan menggunakan analisis deskriptif dan inferensial berdasarkan rumus Wilcoxon sign rank test. Hasil analisis deskriptif menunjukkan bahwa  perilaku bermain game online di rumah sebelum mengikuti layanan konseling kelompok kontrak perilaku, antara lain: 6 siswa yaitu MAB, MRA, YL, J, MR dan MRT memiliki intensitas tinggi bermain game online di rumah. Setelah diberikan layanan konseling kelompok kontrak perilaku, 3 siswa berinisial MRA, YL dan MRT memiliki perilaku bermain game online  tinggi, 3 siswa yaitu MAB, MR, dan J memiliki perilaku bermain game online rendah. Hasil analisis inferensial menunjukkan bahwa perilaku bermain game online di rumah setelah mengikuti layanan konseling kelompok kontrak perilaku lebih rendah dibanding sebelum mengikuti layanan konseling kelompok kontrak perilaku. Hasil penelitian menunjukkan bahwa layanan konseling kelompok kontrak perilaku efektif untuk mengurangi perilaku bermain game online di rumah.


2021 ◽  
Author(s):  
Masato Yanagi ◽  
Tsutomu Hamasaki ◽  
JunJun Akatsuka ◽  
Yuki Endo ◽  
Hayato Takeda ◽  
...  

Abstract Background: One of the major concerns of patients with upper tract urothelial carcinoma (UTUC) treated with nephroureterectomy is intravesical recurrence (IVR). The purpose of the present study was to investigate the predictive risk factors for IVR after laparoscopic nephroureterectomy (LNU) for UTUC.Methods: Clinicopathological and surgical information were collected from the medical records of 73 patients treated with LNU for non-metastatic UTUC, without a history of or concomitant bladder cancer. The association between IVR after LNU and clinicopathological and surgery-related factors, including preoperative urine cytology and pneumoperitoneum time, was analyzed using Cox proportional hazards regression models and the Kaplan–Meier method with log-rank test.Results: During the median follow-up time of 39.1 months, 18 (24.7%) patients had subsequent IVR after LNU. The 3- and 5-year IVR-free survival rates were 76.5% and 74.3%, respectively. In the multivariate Cox regression analysis, positive preoperative urine cytology (hazard ratio [HR]: 3.55; 95% confidence interval [CI]: 1.326–11.327; p=0.011) and prolonged pneumoperitoneum time of ≥ 210 min (HR: 3.40; 95% CI: 1.271–10.692; p=0.014) were independent prognostic factors for IVR-free survival. In patients with positive urine cytology, the Kaplan–Meier method with log-rank test revealed that the 3-year and 5-years IVR free survival rates were 46.3% and 39.7%, respectively, in patients with a prolonged pneumoperitoneum time of ≥ 210 min, which was significantly lower than that in their counterparts (76% and 76%, respectively, p=0.041).Conclusions: In UTUC patients with positive urine cytology, the occurrence of IVR is highly probable when the pneumoperitoneum time of LNU is prolonged (≥ 210 min). Strict follow-up after LNU is highly recommended for these patients.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Masako Ishikawa ◽  
Kentaro Nakayama ◽  
Kohei Nakamura ◽  
Hitomi Yamashita ◽  
Tomoka Ishibashi ◽  
...  

AbstractPrevious studies have largely failed to clarify the relationship between p16INK4A status and cervical adenocarcinoma prognosis. The current study aimed to examine the clinical and pathological significance of p16INK4A expression in several cervical adenocarcinoma subtypes. Eighty-two samples collected from patients with cervical adenocarcinoma were formalin fixed and paraffin embedded. Next, p16INK4A levels were analyzed with immunohistochemistry. Additionally, the relationship between p16INK4A expression and clinicopathological factors as well as prognosis was evaluated. The expression of p16INK4A was mostly detected in all usual cervical adenocarcinoma subtypes. In the gastric type, only a few cases were positive for p16INK4A expression. Results of the Kaplan–Meier analysis indicated that the positive p16INK4A expression in tumor cells was significantly associated with favorable progression-free survival and overall survival in patients with cervical adenocarcinoma (p = 0.018 and p = 0.047, respectively, log-rank test). Our findings suggest that the status of p16INK4A expression may influence prognosis. Thus, p16INK4A expression could be used as a biomarker for improving the prognosis of patients with cervical adenocarcinoma.


2021 ◽  
Vol 11 (18) ◽  
pp. 8543
Author(s):  
Asaf Shely ◽  
Shiri Livne ◽  
Gil Ben-Izhack ◽  
Michal Lokshin ◽  
Shahar Har-Nes ◽  
...  

Background: The purpose of this in vitro study was to compare the implant axis’ spatial position and orientation by using laboratory scanner versus intra-oral scanner with three different scan abutments. Methods: A 3D model was printed with an internal hex implant analog in the place of teeth 35#. Three standard scan abutments were used: MIS (two-piece titanium), AB (two-piece PEEK and titanium base) and ZZ (one-piece PEEK). Each scan abutment was scanned 30 times by TRIOS E3 (laboratory scanner) and 30 times by Omnicam (intra-oral scanner). For each scan, an STL (stereolithography) file was created, and the spatial characterization of each scan abutment was measured in the X, Y, Z coordinates, and rotational and longitudinal angles. The comparison between all the scans was conducted by superimposition of the STL files, using a 3D software. A t-test and Wilcoxon signed-rank test were used. (p < 0.05) Results: Only the MIS scan abutment showed no statistical difference in the X and Z axes. (p < 0.05). All other scan abutments showed a statistical difference in all axes. The rotational angle of the AB scan abutment was twice the angle of the MIS and ZZ scan abutments. Conclusions: All three scan abutments showed a rotational deviation of the implant axis between the laboratory scanner and the intra-oral scanner. The AB scan abutment showed the greatest deviation (1.04 degrees) while the other two abutments showed deviations of about half a degree in relation to the laboratory scan abutment. There is a need for further studies which will examine the influence of geometry, material, and scan abutment parts on the accuracy of the scan obtained.


2021 ◽  
Author(s):  
Ahlem Aboud ◽  
Nizar Rokbani ◽  
Adel Alimi ◽  
Seyedali Mirjalili

<p>Dynamic multi-objective optimization problems (DMOPs) and Many-Objective Optimization Problems (MaOPs) are two classes of the optimization filed which have potential applications in engineering. Modified Multi-Objective Evolutionary Algorithms hybrid approaches seem to be suitable to effectively deal with such problems. However, the Crow Search Algorithm has not yet considered for both DMOP and MaOP. This paper proposes a Distributed <a>Bi-behaviors </a>Crow Search Algorithm (DB-CSA) with two different mechanisms, one corresponding to the search behavior and another to the exploitative behavior with a dynamic switch mechanism. The bi-behaviors CSA chasing profile is defined based on a large Gaussian-like Beta-1 function which ensures diversity enhancement, while the narrow Gaussian Beta-2 function is used to improve the solution tuning and convergence behavior. The DB-CSA approach is developed to solve several types of DMOPs and a set of MaOPs with 2, 3, 5, 7, 8, 10 and 15 objectives. The Inverted General Distance, the Mean Inverted General Distance and the Hypervolume Difference are the main measurement metrics are used to compare the DB-CSA approach to the state-of-the-art MOEAs. All quantitative results are analyzed using the nonparametric Wilcoxon signed rank test with 0.05 significance level which proving the efficiency of the proposed method for solving both 44 DMOPs and MaOPs utilized. </p>


2021 ◽  
Author(s):  
Ahlem Aboud ◽  
Nizar Rokbani ◽  
Adel Alimi ◽  
Seyedali Mirjalili

<p>Dynamic multi-objective optimization problems (DMOPs) and Many-Objective Optimization Problems (MaOPs) are two classes of the optimization filed which have potential applications in engineering. Modified Multi-Objective Evolutionary Algorithms hybrid approaches seem to be suitable to effectively deal with such problems. However, the Crow Search Algorithm has not yet considered for both DMOP and MaOP. This paper proposes a Distributed <a>Bi-behaviors </a>Crow Search Algorithm (DB-CSA) with two different mechanisms, one corresponding to the search behavior and another to the exploitative behavior with a dynamic switch mechanism. The bi-behaviors CSA chasing profile is defined based on a large Gaussian-like Beta-1 function which ensures diversity enhancement, while the narrow Gaussian Beta-2 function is used to improve the solution tuning and convergence behavior. The DB-CSA approach is developed to solve several types of DMOPs and a set of MaOPs with 2, 3, 5, 7, 8, 10 and 15 objectives. The Inverted General Distance, the Mean Inverted General Distance and the Hypervolume Difference are the main measurement metrics are used to compare the DB-CSA approach to the state-of-the-art MOEAs. All quantitative results are analyzed using the nonparametric Wilcoxon signed rank test with 0.05 significance level which proving the efficiency of the proposed method for solving both 44 DMOPs and MaOPs utilized. </p>


2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Zhichao Liu ◽  
Changchun Li

Background. Neuroblastomas are the most frequent extracranial pediatric solid tumors. The prognosis of children with high-risk neuroblastomas has remained poor in the past decade. A powerful signature is required to identify factors associated with prognosis and improved treatment selection. Here, we identified a strong methylation signature that favored the earlier diagnosis of neuroblastoma in patients. Methods. Gene methylation (GM) data of neuroblastoma patients from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) were analyzed using a multivariate Cox regression analysis (MCRA) and univariate Cox proportional hazards regression analysis (UCPHRA). Results. The methylated genes’ signature consisting of eight genes (NBEA, DDX28, TMED8, LOC151174, EFNB2, GHRHR, MIMT1, and SLC29A3) was selected. The signature divided patients into low- and high-risk categories, with statistically significant survival rates (median survival time: 25.08 vs. >128.80 months, log-rank test, P < 0.001 ) in the training group, and the validation of the signature’s risk stratification ability was carried out in the test group (log-rank test, P < 0.01 , median survival time: 30.48 vs. >120.36 months). The methylated genes’ signature was found to be an independent predictive factor for neuroblastoma by MCRA. Functional enrichment analysis suggested that these methylated genes were related to butanoate metabolism, beta-alanine metabolism, and glutamate metabolism, all playing different significant roles in the process of energy metabolism in neuroblastomas. Conclusions. The set of eight methylated genes could be used as a new predictive and prognostic signature for patients with INRG high-risk neuroblastomas, thus assisting in treatment, drug development, and predicting survival.


2021 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Wahyu Jatmiko ◽  
A. Azizon

Purpose Previous studies have challenged the Human Development Index’s (HDI) ability to emulate the achievement of falāh (happiness). This paper aims to evaluate the role of religious values in establishing a positive link between the current measurement of development and falāh. Design/methodology/approach First, this study derives an improved value-loaded development measure from the concept of Maqasid al-Shari’ah (the higher objectives of Islamic law). Second, this paper compares the calculated Maqasid al-Shari’ah Index (MSI) with the HDI of some Organisation of Islamic Cooperation (OIC) countries by using the parametric pair difference z-test and t-test along with the non-parametric Wilcoxon signed-rank test. Finally, the relationship of both indices and the proxy of falāh are examined by using the ordinary least square and the generalised method of moments estimations. Findings As far as the religious-led development is concerned, the HDI underestimates OIC countries’ development progress. Here, the MSI can better embody the attainment of falāh than the HDI. Research limitations/implications This study only covers limited OIC countries due to the data availability issue. Practical implications The cultural-based development stemming from the religious values proves useful for putting the government effort towards the attainment of the objective of human well-being in the right direction. Originality/value To the best of the authors’ knowledge, this is the first study examining the empirical relationship between the MSI and falāh.


Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2657
Author(s):  
Manuel Alaman ◽  
Adrián González-Marrón ◽  
Cristina Lorente ◽  
Cristina Bonastre ◽  
Alicia Laborda

Transversus thoracis plane (TTP) block has demonstrated to produce analgesia in humans undergoing median sternotomy. The objectives of the study were to describe an ultrasound-guided transverse approach to the transversus thoracis plane (t-TTP) and to evaluate the spread of two injectable volumes in canine cadavers. Two cadavers were used to describe relevant gross anatomy of the ventral thoracic area and sonoanatomy between the fifth and sixth costal cartilages. Then, eight cadavers were used to describe the ultrasound-guided injection into the TTP and were dissected to evaluate the injectate spread and the intercostal nerves staining with two different dye-lidocaine volumes: low volume (LV) 0.5 mL kg−1 and high volume (HV) 1 mL kg−1. To compare the spread between both volumes the Fisher’s exact test and Wilcoxon signed-rank test were used. The solution spread along the TTP after all injections, staining a median number (range) of 3 (2–4) and 4 (3–5) nerves with LV and HV, respectively (p = 0.014). The injection of HV versus LV increases the number of stained nerves. Ultrasound-guided t-TTP is a feasible technique that provides staining of several intercostal nerves with a single injection site, so it could be useful to provide analgesia to the ventral chest wall.


2021 ◽  
Vol 4 (3) ◽  
pp. 222
Author(s):  
Eti Rimawati ◽  
Sri Handayani ◽  
Catur Yuantari

Introduction: Symptoms of tuberculosis in children that are not specific require early detection efforts. One of the efforts to carry out early detection is to monitor children's growth and development in posyandu activities. Posyandu cadres have an important role in this. The purpose of this training activity is to increase the knowledge of posyandu cadres in early detection of tuberculosis in children. Method: The target of the training was 21 posyandu cadres who were selected by purposive sampling. Training activities as a form of community service are carried out with the stages of giving a pretest, presentation of material and case and posttest questions. The Wilcoxon Signed Rank Test analysis is used to determine differences in knowledge before and after training.Result Recommendation: All cadres were female, with the lowest education was junior high school (9.8%), the youngest was 38 years old and the oldest was 65 years old. The results of the difference test showed that there was a difference between before and after training (p value 0.0006), indicating that the training method was effective in increasing the knowledge of the cadres


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