Oestrogen receptors in human breast cancer

1982 ◽  
Vol 397 (1) ◽  
pp. 103-108 ◽  
Author(s):  
Hans Skovgaard Poulsen ◽  
Luciano Ozzello ◽  
Johan Andersen
2018 ◽  
Vol 49 (2) ◽  
pp. 91
Author(s):  
N. G. KOSTOMITSOPOULOS (Ν.Γ. ΚΩΣΤΟΜΗΤΣΟΠΟΥΛΟΣ)

The oestrogen receptor is a ligand-activated transcription factor that modulates specific gene expression by binding to short DNA sequences. The study of the role of oestrogen receptor on the expression of the mitogenic actionof oestrogens and oncogenesis lead biomedical research in new approaches of the treatment of oestrogen-dependent tumors by using antioestrogens. Main mechanism of action of antioestrogens is the prevention of oestrogen action by blocking the binding of oestradiol to the oestrogen receptor. Tamoxifen, the most wellknown antioestrogen, is widely used as adjuvant therapy in all stages of human breast cancer. Recently interest is focused on the potential use of "pure" antioestrogens. The use of antioestrogens in veterinary oncology is also under discussion.


1976 ◽  
Vol 33 (3) ◽  
pp. 342-343 ◽  
Author(s):  
J R Masters ◽  
K Sangster ◽  
R A Hawkins ◽  
A A Shivas

1986 ◽  
Vol 409 (2) ◽  
pp. 127-147 ◽  
Author(s):  
Wolfgang Remmele ◽  
Ute Hildebrand ◽  
Hermann A. Hienz ◽  
Peter-Josef Klein ◽  
Matthias Vierbuchen ◽  
...  

1974 ◽  
Vol 30 (2) ◽  
pp. 177-177 ◽  
Author(s):  
G Leclercq ◽  
J C Heuson ◽  
W H Mattheiem

The Lancet ◽  
1985 ◽  
Vol 325 (8425) ◽  
pp. 364-366 ◽  
Author(s):  
J.R.C. Sainsbury ◽  
G.V. Sherbet ◽  
J.R. Farndon ◽  
A.L. Harris

The Lancet ◽  
1982 ◽  
Vol 320 (8291) ◽  
pp. 219 ◽  
Author(s):  
J.O. White ◽  
M.D. Fernandez ◽  
J.I. Burn ◽  
P.D. Sauven ◽  
G. Parmar ◽  
...  

1978 ◽  
Vol 14 (3) ◽  
pp. 303-307 ◽  
Author(s):  
J.R.W. Masters ◽  
R.A. Hawkins ◽  
K. Sangster ◽  
W. Hawkins ◽  
I.I. Smith ◽  
...  

1988 ◽  
Vol 175 (1) ◽  
pp. 89-96 ◽  
Author(s):  
R.A. Hawkins ◽  
E. Killen ◽  
A.L. Tesdale ◽  
K. Sangster ◽  
M. Thomson ◽  
...  

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