The action of lindane in accelerating the spontaneous release of transmitter at the frog neuromuscular junction

1979 ◽  
Vol 308 (2) ◽  
pp. 179-182 ◽  
Author(s):  
S. J. Publicover ◽  
C. J. Duncan
Keyword(s):  
Neuromuscular Junction ◽  
Frog Neuromuscular Junction ◽  
Spontaneous Release

Distribution of spontaneous release along the frog neuromuscular junction

1984 ◽  
Vol 51 (2) ◽  
pp. 247-252 ◽  
Author(s):  
J.P. Tremblay ◽  
R. Robitaille ◽  
G. Grenon
Keyword(s):  
Neuromuscular Junction ◽  
Frog Neuromuscular Junction ◽  
Spontaneous Release

Effect of oxygen at high pressure on spontaneous transmitter release

1978 ◽  
Vol 235 (5) ◽  
pp. C233-C237 ◽  
Author(s):  
J. S. Colton ◽  
C. A. Colton
Keyword(s):  
High Pressure ◽  
Neuromuscular Junction ◽  
Membrane Resistance ◽  
Membrane Properties ◽  
Frog Neuromuscular Junction ◽  
Spontaneous Release ◽  
Gauge Pressure ◽  
Mepp Amplitude ◽  
Effect Of Oxygen ◽  
Excitatory Transmitter

The effect of oxygen at high pressure (OHP) on resting membrane properties (effective membrane resistance (Reff) and membrane potential (Vm)) and the spontaneous release of excitatory transmitter were examined at the lobster neuromuscular junction. Pressurization with 100% oxygen to 150 pounds per square inch gauge pressure (psig) or with nitrogen to 150 psig (7,000 mmHg nitrogen and 135 mmHg oxygen) produced a decrease in Reff associated with a hyperpolarization of Vm. These changes, however, returned to control values within 20--30 min after completion of pressurization. Spontaneous release of excitatory transmitter was shown to increase dramatically in the presence of 100% oxygen at 150 psig. The increase in miniature end-plate potential (MEPP) frequency persisted beyond the transient changes seen with Reff and Vm. This effect was selective to oxygen, as pressurization with nitrogen did not produce an increase in MEPP frequency. No change in average MEPP amplitude was seen with either OHP or pressure alone. An OHP-induced increase in MEPP frequency was also seen at the frog neuromuscular junction. The results indicate that both glutamate-mediated and acetylcholine-mediated synaptic transmission are altered by OHP.

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