Inhibitory effect of methylxanthines on feedback control of glomerular filtration rate in the rat kidney

1977 ◽  
Vol 369 (1) ◽  
pp. 39-48 ◽  
Author(s):  
J. Schnermann ◽  
H. Osswald ◽  
M. Hermle
Keyword(s):  
Glomerular Filtration Rate ◽  
Feedback Control ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Rat Kidney ◽  
Inhibitory Effect

Endothelin-3 Modulates Glomerular Filtration Rate in the Isolated Perfused Rat Kidney

1992 ◽  
Vol 15 (6) ◽  
pp. 325-333 ◽  
Author(s):  
H. Schramek ◽  
C.C. Willinger ◽  
G. Gstraunthaler ◽  
W. Pfaller
Keyword(s):  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Rat Kidney ◽  
Isolated Perfused Rat Kidney ◽  
Perfused Rat Kidney ◽  
Endothelin 3

Influence of Contrast Media on Single Nephron Glomerular Filtration Rate in Rat Kidney: A Comparison between Diatrizoate, Iohexol, Ioxaglate, and Iotrolan

1992 ◽  
Vol 33 (6) ◽  
pp. 596-599
Author(s):  
J. Ueda ◽  
A. Nygren ◽  
P. Hansell ◽  
U. Erikson
Keyword(s):  
Glomerular Filtration Rate ◽  
Contrast Media ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Rat Kidney ◽  
Control Value ◽  
Osmotic Effect ◽  
Micropuncture Technique ◽  
Single Nephron

The effects of slow (10 min) i.v. infusions of contrast media (CM, 1 600 mg I/kg b.w.) on single nephron glomerular filtration rate (SNGFR) in the rat kidney were investigated using a micropuncture technique. Diatrizoate, iohexol, or ioxaglate did not change SNGFR, although a tendency towards a transient suppression was seen during the infusion phase. Iotrolan infusion, however, decreased SNGFR (p < 0.05) and the value still remained below the control value 25 min after the start of infusion. Iotrolan is a nonionic dimeric CM and has a lower osmotic effect in the tubules than the ionic dimeric CM and the monomeric CM when given in iodine equivalent doses. These characteristics of iotrolan have probably some influence on the depression of SNGFR after iotrolan injection.

scholarly journals Rapid diagnosis and quantification of acute kidney injury using fluorescent ratio-metric determination of glomerular filtration rate in the rat

2010 ◽  
Vol 299 (5) ◽  
pp. F1048-F1055 ◽  
Author(s):  
Exing Wang ◽  
Ruben M. Sandoval ◽  
Silvia B. Campos ◽  
Bruce A. Molitoris
Keyword(s):  
Acute Kidney Injury ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Fluorescence Probe ◽  
Rat Kidney ◽  
Kidney Injury ◽  
Rapid Diagnosis ◽  
Fluorescent Intensity ◽  
Two Photon

The rapid diagnosis and quantification of acute kidney injury (AKI) severity remain high clinical priorities. By combining intravital fluorescent ratiometric two-photon kidney imaging and the two-compartment pharmacokinetics model, we demonstrate that rapid quantification of glomerular filtration rate (GFR) can be achieved in physiologic and AKI rat kidney models. Using a bolus infusion of a mixture of FITC-inulin and a 500-kDa Texas Red dextran, a full spectrum of GFR values, ranging from 0.17 to 1.12 ml·min−1·100 g−1, was obtained. The GFR values thus determined correlated well with values obtained by the standard 2-h inulin infusion clearance method with a Pearson's correlation coefficient of 0.85. In addition, postischemia deterioration was studied by measuring GFR using the two-photon approach during 24 h following a 45-min bilateral ischemia clamp model. The GFR was found to decline sharply during the initial 4 h followed by a nadir with little sign of rising over the ensuing 24-h period. Moreover, a FITC-labeled 5-kDa dextran was identified as having nearly identical filtration characteristics as FITC-inulin, but had markedly increased fluorescent intensity, thus minimizing the quantity needed for individual studies. The technique reported allows for very rapid GFR determinations, within 10–15 min, based on plasma clearance of a freely filtered fluorescence probe, instead of a prolonged one-compartment interstitial space reporter molecule clearance employed by other technologies.

Influence of Contrast Media on Single Nephron Glomerular Filtration Rate in Rat Kidney

1992 ◽  
Vol 33 (6) ◽  
pp. 596-599 ◽  
Author(s):  
J. Ueda ◽  
A. Nygren ◽  
P. Hansell ◽  
U. Erikson
Keyword(s):  
Glomerular Filtration Rate ◽  
Contrast Media ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Rat Kidney ◽  
Single Nephron
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