Insight into the active-site structure and function of cytochrome oxidase by analysis of site-directed mutants of bacterial cytochromeaa 3 and cytochromebo

1993 ◽  
Vol 25 (2) ◽  
pp. 121-136 ◽  
Author(s):  
Jonathan P. Hosler ◽  
Shelagh Ferguson-Miller ◽  
Melissa W. Calhoun ◽  
Jeffrey W. Thomas ◽  
John Hill ◽  
...  
Keyword(s):  
Cytochrome Oxidase ◽  
Active Site ◽  
Structure And Function ◽  
Site Structure ◽  
Active Site Structure ◽  
And Function ◽  
Insight Into

Metalloenzyme Active-Site Structure and Function through Multifrequency CW and Pulsed ENDOR

1993 ◽  
pp. 151-218 ◽  
Author(s):  
Brian M. Hoffman ◽  
Victoria J. DeRose ◽  
Peter E. Doan ◽  
Ryszard J. Gurbiel ◽  
Andrew L. P. Houseman ◽  
...  
Keyword(s):  
Active Site ◽  
Structure And Function ◽  
Site Structure ◽  
Active Site Structure ◽  
And Function

scholarly journals Plasmodium subtilisin-like protease 1 (SUB1): Insights into the active-site structure, specificity and function of a pan-malaria drug target

2012 ◽  
Vol 42 (6) ◽  
pp. 597-612 ◽  
Author(s):  
Chrislaine Withers-Martinez ◽  
Catherine Suarez ◽  
Simone Fulle ◽  
Samir Kher ◽  
Maria Penzo ◽  
...  
Keyword(s):  
Active Site ◽  
Drug Target ◽  
Site Structure ◽  
Active Site Structure ◽  
And Function

Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase

2020 ◽  
Author(s):  
Vikram V. Shende ◽  
Yogan Khatri ◽  
Sean A. Newmister ◽  
Jacob N. Sanders ◽  
Petra Lindovska ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Active Site ◽  
Structure And Function ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Bond Forming ◽  
And Function ◽  
Insight Into

This report details the discovery and characterization of a versatile bacterial cytochrome P450, NzeB, which catalyzes the dimerization of diketopiperazines via enzymatic C–H functionalization. This includes the first high-resolution crystal structure of a diketopiperazine dimerase, which along with active site via mutagenesis and quantum mechanical calculations, provides insight into the selectivity and mechanism of these enzymes.

scholarly journals Structure and Function of NzeB, a Versatile C–C and C–N Bond Forming Diketopiperazine Dimerase

2020 ◽  
Author(s):  
Vikram V. Shende ◽  
Yogan Khatri ◽  
Sean A. Newmister ◽  
Jacob N. Sanders ◽  
Petra Lindovska ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Cytochrome P450 ◽  
Active Site ◽  
Structure And Function ◽  
Quantum Mechanical ◽  
Quantum Mechanical Calculations ◽  
Bond Forming ◽  
And Function ◽  
Insight Into

This report details the discovery and characterization of a versatile bacterial cytochrome P450, NzeB, which catalyzes the dimerization of diketopiperazines via enzymatic C–H functionalization. This includes the first high-resolution crystal structure of a diketopiperazine dimerase, which along with active site via mutagenesis and quantum mechanical calculations, provides insight into the selectivity and mechanism of these enzymes.

Structure and function of neural networks in the retina

1988 ◽  
Vol 46 ◽  
pp. 26-27
Author(s):  
Peter Sterling
Keyword(s):  
Ganglion Cells ◽  
Three Dimensional ◽  
Structure And Function ◽  
Synaptic Connections ◽  
Visual Axis ◽  
One Dimensional ◽  
Cat Retina ◽  
Ultrathin Sections ◽  
And Function ◽  
Insight Into

The synaptic connections in cat retina that link photoreceptors to ganglion cells have been analyzed quantitatively. Our approach has been to prepare serial, ultrathin sections and photograph en montage at low magnification (˜2000X) in the electron microscope. Six series, 100-300 sections long, have been prepared over the last decade. They derive from different cats but always from the same region of retina, about one degree from the center of the visual axis. The material has been analyzed by reconstructing adjacent neurons in each array and then identifying systematically the synaptic connections between arrays. Most reconstructions were done manually by tracing the outlines of processes in successive sections onto acetate sheets aligned on a cartoonist's jig. The tracings were then digitized, stacked by computer, and printed with the hidden lines removed. The results have provided rather than the usual one-dimensional account of pathways, a three-dimensional account of circuits. From this has emerged insight into the functional architecture.

Sign in / Sign up

Export Citation Format

Share Document