Regulation of the mitochondrial outer membrane channel, VDAC

1987 ◽  
Vol 19 (4) ◽  
pp. 309-320 ◽  
Author(s):  
Marco Colombini
Keyword(s):  
Outer Membrane ◽  
Mitochondrial Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

scholarly journals Bacterial Expression and Characterization of the Mitochondrial Outer Membrane Channel

1998 ◽  
Vol 273 (22) ◽  
pp. 13794-13800 ◽  
Author(s):  
Daniel A. Koppel ◽  
Kathleen W. Kinnally ◽  
Paul Masters ◽  
Michael Forte ◽  
Elizabeth Blachly-Dyson ◽  
...  
Keyword(s):  
Outer Membrane ◽  
Bacterial Expression ◽  
Mitochondrial Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel

Voltage gating of the mitochondrial outer membrane channel VDAC is regulated by a very conserved protein

1991 ◽  
Vol 260 (2) ◽  
pp. C371-C374 ◽  
Author(s):  
M. Y. Liu ◽  
M. Colombini
Keyword(s):  
Outer Membrane ◽  
Physiological Role ◽  
Mitochondrial Outer Membrane ◽  
Voltage Sensitivity ◽  
Membrane Channel ◽  
Mitochondrial Fractions ◽  
Voltage Dependent ◽  
Outer Membrane Channel ◽  
Vdac Channels ◽  
Closing Rate

Soluble protein preparations obtained from the mitochondrial fractions of three very different organisms, Neurospora crassa, rat, and potato, were discovered to greatly enhance the voltage sensitivity of the mitochondrial outer membrane channel, VDAC. The active ingredient, referred to as the VDAC modulator, increased the rate of voltage-dependent channel closure by approximately 10-fold. The modulator from one species increased the closing rate of VDAC channels from all three species. The activity is pronase sensitive and not mimicked by another negatively charged protein, BSA. The highly conserved property of this modulator suggests an important physiological role in regulating mitochondrial function.

scholarly journals NADH regulates the gating of VDAC, the mitochondrial outer membrane channel.

1994 ◽  
Vol 269 (3) ◽  
pp. 1614-1616
Author(s):  
M. Zizi ◽  
M. Forte ◽  
E. Blachly-Dyson ◽  
M. Colombini
Keyword(s):  
Outer Membrane ◽  
Mitochondrial Outer Membrane ◽  
Membrane Channel ◽  
Outer Membrane Channel
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