Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system. VII. Effect of benzhydrylureas on the cytochrome P-450-dependent liver monooxygenase system

1993 ◽  
Vol 27 (6) ◽  
pp. 395-397 ◽  
Author(s):  
A. A. Bakibaev ◽  
R. R. Akhmedzhanov ◽  
T. P. Novozheeva ◽  
V. D. Filimono ◽  
L. G. Tignibidina ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Hepatic Monooxygenase ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

Reconstitution of liver monooxygenase system in solution from cytochrome P-450 and NADPH-specific flavoprotein monomers

1986 ◽  
Vol 139 (3) ◽  
pp. 883-888 ◽  
Author(s):  
G.I. Bachmanova ◽  
E.D. Skotselyas ◽  
I.P. Kanaeva ◽  
G.P. Kuznetsova ◽  
S.A. Gordeev ◽  
...  
Keyword(s):  
Monooxygenase System ◽  
Liver Monooxygenase ◽  
Cytochrome P 450

Amide- and urea-based synthetic anticonvulsants, antihypoxics, and inducers of the hepatic monooxygenase system. VIII. Effect of benzhydrylureas and m-chlorobenzhydrylureas on the rat liver monooxygenase system

1993 ◽  
Vol 27 (6) ◽  
pp. 398-401 ◽  
Author(s):  
T. P. Novozheeva ◽  
R. R. Akhmedzhanov ◽  
A. S. Saratikov ◽  
A. A. Bakibaev ◽  
V. D. Filimonov ◽  
...  
Keyword(s):  
Rat Liver ◽  
Monooxygenase System ◽  
Hepatic Monooxygenase ◽  
Liver Monooxygenase

Growth hormone depresses ethylmorphine demethylase activity: correlation with decreased levels of fast-turnover cytochrome P-450 in hypophysectomized female rats

1988 ◽  
Vol 66 (7) ◽  
pp. 868-872
Author(s):  
Birgit M. Vockentanz ◽  
Bruce B. Virgo
Keyword(s):  
Growth Hormone ◽  
Cytochrome C ◽  
Female Rats ◽  
Monooxygenase System ◽  
Demethylase Activity ◽  
Hepatic Monooxygenase ◽  
Cytochrome P 450 ◽  
Slow Turnover ◽  
Nadph Cytochrome C Reductase

The hepatic monooxygenase system was studied in hypophysectomized female rats infused for 5 days with ovine growth hormone (GH). At 7.5 μg∙h−1 GH decreased the total cytochrome P-450 by 16%; at 10 μg∙h−1 it reduced both cytochrome P-450 (31%) and the activity of ethylmorphine demethylase (31%). GH did not alter the activities of NADPH cytochrome c reductase or aniline hydroxylase. The lower GH dose decreased the amount of fast- and slow-turnover P-450 by 11 and 38%, respectively, while the higher dose decreased both by 49%. The loss of demethylase activity therefore correlates with the loss of fast-tumover P-450. This component is relatively more abundant in the female (fast: slow turnover of 4.3) than the male (fast: slow turnover of 2.5). GH did not affect the half-lives of the P-450 components, suggesting that it decreases their synthesis. The P-450 concentration in microsomes from GH-treated animals did not increase after incubation with hemin, suggesting that in vivo the hormone does not lower P-450 synthesis via depression of heme. Puromycin mimicked the effect of GH and when given with the hormone their effects on the P-450 levels were multiplicative (p < 0.05), suggesting different modes of action and that GH does not decrease P-450 by acting at translation.

scholarly journals Benzobarbital and fluorbenzobarbital - hepatic monooxygenase system phenobarbital-like inducers

2011 ◽  
Vol 10 (5) ◽  
pp. 78-81 ◽  
Author(s):  
T. P. Novozheyeva ◽  
M. I. Smagina ◽  
N. A. Cherevko ◽  
S. N. Fateyeva
Keyword(s):  
Large Degree ◽  
Major Metabolite ◽  
Monooxygenase System ◽  
Oxidation Activity ◽  
Hepatic Monooxygenase ◽  
Cytochrome P 450 ◽  
Hepatic Cytochrome

Benzobarbital and fluorbenzobarbital as monooxygenase system inductors increase the hepatic cytochrome P-450 level and the content of its isoenzymes 2B6, 2C9, 2Å1, accelerate aminopyrine, 7-ethoxyresorufine, 7-pentoxyresorufine, aniline and androstendione oxidation. Activity of benzobarbital and fluorbenzobarbital as inductors is to a large degree due to the action of their major metabolite — phenobarbital. Benzobarbital and fluorbenzobarbital unlike phenobarbital induce isoenzyme 3A4, responsible for androstendione 16b-OH-hydroxylation. PCN-type induction activity posses also native molecules of benzobarbital and fluorbenzobarbital.

IDentification of a microsomal retinoic acid synthase as a microsomal cytochrome P-450-linked monooxygenase system

1993 ◽  
Vol 25 (12) ◽  
pp. 1775-1784 ◽  
Author(s):  
Tomita Shuhei ◽  
Tsujita Maki ◽  
Matsuo Yoshinori ◽  
Yubisui Toshitsugu ◽  
Ichikawa Yoshiyuki
Keyword(s):  
Retinoic Acid ◽  
Monooxygenase System ◽  
Microsomal Cytochrome ◽  
Cytochrome P 450
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