Changes in the acetylcholine-cholinesterase system in the course of experimental botulism

1976 ◽  
Vol 81 (1) ◽  
pp. 30-32 ◽  
Author(s):  
S. G. Khotenko ◽  
V. I. Goncharova
Keyword(s):  
Experimental Botulism

ARTIFICIAL-RESPIRATION STUDIES IN MONKEYS INCAPACITATED BY EXPERIMENTAL BOTULISM

1965 ◽  
Author(s):  
Fred W. Oberst ◽  
Paul Cresthull ◽  
James W. Crook ◽  
Michael J. House
Keyword(s):  
Artificial Respiration ◽  
Experimental Botulism

scholarly journals THE EFFECT OF ANESTHESIA AND OF SEDATIVES ON THE SERUM THERAPY OF EXPERIMENTAL BOTULISM

1924 ◽  
Vol 39 (4) ◽  
pp. 517-532 ◽  
Author(s):  
Jacques J. Bronfenbrenner ◽  
Harry Weiss
Keyword(s):  
Guinea Pigs ◽  
Oxygen Mixture ◽  
Published Data ◽  
Human Beings ◽  
Rapid Progress ◽  
Similar Nature ◽  
Nitrous Oxide Oxygen ◽  
Usual Rate ◽  
Serum Therapy ◽  
Experimental Botulism

When guinea pigs are fed large amounts of botulinus toxin, they develop symptoms of intoxication within 6 hours and die usually within 12 hours after the feeding of toxin. If very large amounts of toxin are introduced intraperitoneally, the animals may show symptoms of intoxication at the end of the 1st hour and die usually within 2 hours following the administration of toxin. If these animals are placed under anesthesia following the administration of toxin, the intoxication proceeds much more slowly. Anesthesia, by ether, is effective in this manner whether the toxin is given per os or intraperitoneally. The life of guinea pigs kept under ether after the administration of lethal amounts of toxin is prolonged by a period approximately equal to that during which the administration of the anesthetic is continued. When anesthesia is discontinued, the intoxication proceeds at its usual rate. It appears, therefore, that administration of ether delays the rate of intoxication but does not alter the toxin or the nature of the mechanism of intoxication. Anesthesia thus delays the progress of intoxication not only when administered immediately after the intake of toxin, but when administered much later after the intoxication has already progressed far enough to cause definite objective symptoms of poisoning. At this late stage of intoxication, the unsupported serum therapy of botulism in guinea pigs usually remains without effect. If, however, the animals are anesthetized at this time and kept under the influence of ether for some time, antitoxin therapy becomes effective. Indeed the antitoxin treatment can be delayed further for several hours, provided the animal is kept under anesthesia during the interval. Results of a similar nature were obtained with luminal sodium, nitrous oxide-oxygen mixture, and morphine used in place of ether. In view of the fact that the published data indicate that botulinus antitoxin has thus far failed to give beneficial results in the treatment of botulism in human beings because, as it would seem, of the rapid progress of intoxication, any method of delaying the progress of intoxication to supplement the antitoxin therapy deserves consideration.

Evaluation of botulinum antitoxin, supportive therapy, and artificial respiration in monkeys with experimental botulism

1968 ◽  
Vol 9 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Fred W. Oberst ◽  
James W. Crook ◽  
Paul Cresthull ◽  
Michael J. House
Keyword(s):  
Artificial Respiration ◽  
Supportive Therapy ◽  
Experimental Botulism

Experimental Botulism in Gallinaceous Birds

1971 ◽  
Vol 15 (4) ◽  
pp. 716 ◽  
Author(s):  
W. B. Gross ◽  
L. DS. Smith
Keyword(s):  
Experimental Botulism

Experimental botulism in monkeys—A clinical pathological study

1967 ◽  
Vol 6 (1) ◽  
pp. 84-95 ◽  
Author(s):  
Brunildo A. Herrero ◽  
Allen E. Ecklund ◽  
C. Spencer Streett ◽  
Duane F. Ford ◽  
John K. King
Keyword(s):  
Pathological Study ◽  
Experimental Botulism

Mechanism of disturbances of electrical activity of spinal cord neurons in experimental botulism

1968 ◽  
Vol 66 (5) ◽  
pp. 1201-1204 ◽  
Author(s):  
V. V. Mikhailov ◽  
V. V. Korolev
Keyword(s):  
Spinal Cord ◽  
Electrical Activity ◽  
Spinal Cord Neurons ◽  
Experimental Botulism

Pathogenetic combination therapy of experimental botulism

1987 ◽  
Vol 104 (5) ◽  
pp. 1522-1524
Author(s):  
G. N. Kryzhanovskii ◽  
V. V. Morrison
Keyword(s):  
Combination Therapy ◽  
Experimental Botulism

Role of acetylcholine in disturbances of axoplasm transport in thick medullated nerve fibers in experimental botulism and tetanus

1969 ◽  
Vol 67 (6) ◽  
pp. 623-625
Author(s):  
V. V. Mikhailov ◽  
L. A. Chekhovskaya
Keyword(s):  
Nerve Fibers ◽  
Experimental Botulism
Sign in / Sign up

Export Citation Format

Share Document