Role of intracellular and extracellular calcium in activation of serotonin-induced contraction of pulmonary arterial smooth muscle

1988 ◽  
Vol 106 (3) ◽  
pp. 1211-1214
Author(s):  
V. A. Buryi ◽  
A. V. Gurkovskaya ◽  
N. I. Gokina ◽  
M. F. Shuba
Keyword(s):  
Smooth Muscle ◽  
Extracellular Calcium ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Pulmonary Arterial Smooth Muscle

The role of ERK1/2 in 15-HETE-inhibited apoptosis in pulmonary arterial smooth muscle cells

2010 ◽  
Vol 31 (1) ◽  
pp. 45-52 ◽  
Author(s):  
Jing Jiang ◽  
Shuang Wang ◽  
Zhigang Wang ◽  
Jun Ma ◽  
Shulin Liu ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle

scholarly journals Role of histone deacetylases in regulation of phenotype of ovine newborn pulmonary arterial smooth muscle cells

2013 ◽  
Vol 46 (6) ◽  
pp. 654-664 ◽  
Author(s):  
Q. Yang ◽  
M. J. Dahl ◽  
K. H. Albertine ◽  
R. Ramchandran ◽  
M. Sun ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Histone Deacetylases ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle

Role of Na + /H + Exchanger 1 in Regulating Resistance to Apoptosis in Pulmonary Arterial Smooth Muscle Cells

2020 ◽  
Vol 34 (S1) ◽  
pp. 1-1
Author(s):  
Micheal Munson ◽  
Xin Yun ◽  
Haiyang Jiang ◽  
Nicolas Philip ◽  
John Huetsch ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle

scholarly journals Role of RASEF hypermethylation in cigarette smoke-induced pulmonary arterial smooth muscle remodeling

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Qinghai Li ◽  
Jixing Wu ◽  
Yongjian Xu ◽  
Lu Liu ◽  
Jungang Xie
Keyword(s):  
Smooth Muscle ◽  
Cigarette Smoke ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Pulmonary Arterial Smooth Muscle ◽  
Muscle Remodeling

scholarly journals Molecular basis of hypoxia-induced pulmonary vasoconstriction: role of voltage-gated K+ channels

2001 ◽  
Vol 281 (1) ◽  
pp. L1-L12 ◽  
Author(s):  
Elizabeth A. Coppock ◽  
Jeffrey R. Martens ◽  
Michael M. Tamkun
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Arterial Smooth Muscle Cell ◽  
Arterial Smooth Muscle ◽  
Voltage Gated ◽  
Pulmonary Vasoconstriction ◽  
Pulmonary Arterial ◽  
Pulmonary Arterial Smooth Muscle

The hypoxia-induced membrane depolarization and subsequent constriction of small resistance pulmonary arteries occurs, in part, via inhibition of vascular smooth muscle cell voltage-gated K+(KV) channels open at the resting membrane potential. Pulmonary arterial smooth muscle cell KV channel expression, antibody-based dissection of the pulmonary arterial smooth muscle cell K+ current, and the O2 sensitivity of cloned KV channels expressed in heterologous expression systems have all been examined to identify the molecular components of the pulmonary arterial O2-sensitive KV current. Likely components include Kv2.1/Kv9.3 and Kv1.2/Kv1.5 heteromeric channels and the Kv3.1b α-subunit. Although the mechanism of KV channel inhibition by hypoxia is unknown, it appears that KV α-subunits do not sense O2 directly. Rather, they are most likely inhibited through interaction with an unidentified O2 sensor and/or β-subunit. This review summarizes the role of KV channels in hypoxic pulmonary vasoconstriction, the recent progress toward the identification of KV channel subunits involved in this response, and the possible mechanisms of KV channel regulation by hypoxia.

Effect of intracellular pH on ferret pulmonary arterial smooth muscle cell calcium homeostasis and pressure

1996 ◽  
Vol 80 (2) ◽  
pp. 496-505 ◽  
Author(s):  
I. S. Farrukh ◽  
J. R. Hoidal ◽  
W. H. Barry
Keyword(s):  
Smooth Muscle ◽  
Intracellular Ph ◽  
Vascular Reactivity ◽  
Intracellular Acidosis ◽  
Arterial Smooth Muscle ◽  
Pulmonary Arterial ◽  
Arterial Smooth Muscle Cells ◽  
Pulmonary Arterial Smooth Muscle ◽  
Isolated Lungs

In this study, we investigated the role of Na+/H+ antiport in regulating cytosolic (intracellular) pH (pHi) in isolated and cultured ferret pulmonary arterial smooth muscle cells (PSMC). We also studied the effects of modulating pHi on the cytosolic (intracellular) calcium concentration ([Ca2+]i) in the PSMC and on the pulmonary arterial pressure (Ppa) of isolated ferret lungs. pHi was modulated by the NH4Cl washout method. To eliminate the contribution of Cl-/HCO3- exchangers, the PSMC and isolated lungs were perfused in HCO3- free buffer. Blocking the Na+/H+ antiporter decreased baseline pHi and prevented the recovery from NH4Cl washout-induced intracellular acidosis. Intracellular alkalinization caused an initial transient increase in both [Ca2+]i and Ppa that were dependent on extracellular Ca2+ entry. Maintaining cytosolic alkalinization caused another increase in Ppa that was not associated with an increase in [Ca2+]i. Intracellular acidosis also caused an increase in [Ca2+]i and Ppa. The cytosolic acidosis-induced increase in [Ca2+]i and Ppa were mediated by both extracellular Ca2+ influx and release of stored intracellular Ca2+. Cytosolic acidosis also appears to have a direct effect on the smooth muscle contractile elements. Both cytosolic alkalosis and acidosis increased vascular reactivity.

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