Characteristics of the spectrum of psychotropic activity of sodium hydroxybutyrate

1979 ◽  
Vol 88 (5) ◽  
pp. 1297-1298 ◽  
Author(s):  
I. S. Morozov ◽  
T. A. Voronina
Keyword(s):  
Sodium Hydroxybutyrate ◽  
Psychotropic Activity

scholarly journals Phytochemical and Psychotropic Research of Motherwort (Leonurus cardiaca L.) Modified Dry Extracts

Plants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 230
Author(s):  
Oleh Koshovyi ◽  
Ain Raal ◽  
Igor Kireyev ◽  
Nadiya Tryshchuk ◽  
Tetiana Ilina ◽  
...  
Keyword(s):  
Amino Acids ◽  
Chemical Composition ◽  
Phenolic Compounds ◽  
Pharmacological Activity ◽  
Ellagic Acid ◽  
Hydroxycinnamic Acids ◽  
Psychotropic Activity ◽  
Phytochemical Analysis ◽  
Phenolic Substances ◽  
Leonurus Cardiaca

The prospect of creating a new medicine with psychotropic activity is shown as a result of studying the chemical composition and pharmacological activity of modified dry extracts of motherwort (Leonurus cardiaca L.) tincture. The most promising substances were the dry extracts, modified by adding small amounts of arginine, valine, phenylalanine, glycine, lysine, and alanine. A total of 15 main phenolic substances were found in the extracts, and eight of them were identified. There were also 10 hydroxycinnamic acids in these extracts, three of which were identified (chlorogenic, caffeic, and rosmarinic acids). The dominant hydroxycinnamic acids were chlorogenic and caffeic acids. Among flavonoids, catechin, hyperoside, and rutin were identified. It should be noted that the extracts had a significant content of ellagic acid. On the basis of the results of the phytochemical analysis of the extracts, it can be concluded that the composition of phenolic compounds does not differ significantly, and the main differences are related to amino acids, which obviously have an impact on the overall pharmacological effect. The results obtained indicate the presence of anxiolytic activity in the motherwort extracts studied in complex with amino acids. The extracts with glycine, valine, and arginine were more effective in reducing anxiety in animals.

Synthesis of complex azabicyclo[3.3.1]nonane esters and their psychotropic activity

1986 ◽  
Vol 20 (12) ◽  
pp. 838-840
Author(s):  
T. T. Omarov ◽  
A. S. Zaks ◽  
T. A. Kapitonenko ◽  
S. A. Baisalbaeva ◽  
B. M. Sultanbaeva
Keyword(s):  
Psychotropic Activity

ChemInform Abstract: Synthesis and Psychotropic Activity of 1-(Hydroxy(acetoxy)phenyl)-1,4-dihydropyrimidin-4-ones.

ChemInform ◽  
1990 ◽  
Vol 21 (9) ◽  
Author(s):  
YU. A. ZHDANOV ◽  
I. V. VEDERNIKOVA ◽  
YU. N. SIMKINA ◽  
YU. I. RYABUKHIN ◽  
M. I. KHAITIN ◽  
...  
Keyword(s):  
Psychotropic Activity

Synthesis and Psychotropic Activity of Arylhydroxyphosphorylacetic Acid Hydrazides and their Salts

2013 ◽  
Vol 47 (8) ◽  
pp. 415-418
Author(s):  
I. P. Pashina ◽  
I. I. Semina ◽  
S. A. Sidullina ◽  
R. I. Tarasova ◽  
M. B. Gazizov ◽  
...  
Keyword(s):  
Psychotropic Activity

An EEG-behavioral study of sodium hydroxybutyrate in humans

1966 ◽  
Vol 20 (5) ◽  
pp. 506-512 ◽  
Author(s):  
David R. Metcalf ◽  
Robert N. Emde ◽  
James T. Stripe
Keyword(s):  
Sodium Hydroxybutyrate ◽  
Behavioral Study

Effect of sodium hydroxybutyrate on myocardial high-energy phosphates, function, and ultrastructure after blood loss

1984 ◽  
Vol 97 (3) ◽  
pp. 289-292
Author(s):  
G. A. Boyarinov ◽  
N. A. Shvets ◽  
L. B. Snopova ◽  
N. V. Khvorov
Keyword(s):  
Blood Loss ◽  
High Energy ◽  
Sodium Hydroxybutyrate ◽  
High Energy Phosphates

Potential Psychotropic Activity of Phlebotropic Drugs: Weak Interactions with Brain Benzodiazepine Receptors

1994 ◽  
Vol 9 (1) ◽  
pp. 32-36 ◽  
Author(s):  
W. Blätter ◽  
P. Schoch
Keyword(s):  
Weak Interactions ◽  
Benzodiazepine Receptors ◽  
Positive Influence ◽  
Binding Activity ◽  
Psychotropic Activity ◽  
Venous Disease ◽  
Receptor Binding Activity ◽  
Psychometric Studies ◽  
Organic Disorder

Background: Epidemiological and psychometric studies have provided evidence that some symptoms of venous disease might reflect a psychosomatic rather than organic disorder. Traditionally, plant extracts are prescribed to alleviate such symptoms. Since benzodiazepines (BZ) and BZ-like compounds are present in various plants, we studied potential interactions of ‘phlebotropic’ drugs with BZ receptors. Methods: Six drug preparations used in phlebology and extracts of hop and valerian were tested for neuronal and mitochondrial BZ receptor binding activity in vitro. In addition, plasma samples of volunteers who ingested phlebotropic drugs for 3 weeks were assayed for the presence of BZ-like activity. Results: All phlebotropic drug preparations interacted weakly with central and/or peripheral BZ receptors in vitro. Their diazepam-equivalent concentrations were, however, too low to be of pharmacological relevance. No binding activity was recovered in the blood of volunteers pretreated with phlebotropic drugs. Conclusion: The positive influence of so-called ‘phlebotropic’ drugs on the subjective symptoms of venous disease is not mediated through BZ receptors.

ChemInform Abstract: SYNTHESIS AND STUDY OF THE PSYCHOTROPIC ACTIVITY OF N-ARYLACETYLFORMAMIDE OXIME HYDRAZONES

1983 ◽  
Vol 14 (38) ◽  
Author(s):  
I. A. POPLAVSKAYA ◽  
R. G. KURMANGALIEVA ◽  
S. F. KHALILOVA ◽  
A. S. ZAKS ◽  
T. A. KAPITONENKO
Keyword(s):  
Psychotropic Activity

Calculation of the effects of substituents in 1,4-benzodiazepines on their psychotropic activity

1989 ◽  
Vol 23 (1) ◽  
pp. 61-65 ◽  
Author(s):  
O. A. Raevskii ◽  
A. M. Sapegin ◽  
I. I. Kitova ◽  
T. A. Voronina ◽  
S. B. Seredenin ◽  
...  
Keyword(s):  
Psychotropic Activity

Pro-convulsant effects: A neglected dimension of psychotropic activity

2013 ◽  
Vol 47 (11) ◽  
pp. 998-1001 ◽  
Author(s):  
Onome Atigari ◽  
David Healy
Keyword(s):  
Psychotropic Activity
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