Activity rhythms in inbred mice. I. Genetic analysis with recombinant inbred strains

1991 ◽  
Vol 21 (2) ◽  
pp. 117-129 ◽  
Author(s):  
Jacques Beau
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Inbred Mice ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Activity Rhythms

GENETIC ANALYSIS OF PLASMA CORTICOSTERONE LEVELS IN TWO INBRED STRAINS OF MICE

1972 ◽  
Vol 55 (2) ◽  
pp. 415-420 ◽  
Author(s):  
B. E. ELEFTHERIOU ◽  
D. W. BAILEY
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Epistatic Interaction ◽  
Genetic Model ◽  
Inbred Strains ◽  
Plasma Corticosterone ◽  
Experimental Results ◽  
Recombinant Inbred Strains ◽  
Inbred Strains Of Mice

SUMMARY Plasma corticosterone levels were determined fluorometrically in mice of two unrelated highly inbred strains, C57BL/6By and BALB/cBy, and in seven of their derived recombinant-inbred strains as well as their F1 hybrid and backcross generations necessary to arrive at a genetic model for plasma corticosterone levels. It was concluded that the simplest genetic model, and one which fits the experimental results, was one which assumed that plasma corticosterone levels are controlled genetically by two loci with the epistatic interaction indicating dependency of pathways of action for the two genes.

scholarly journals Genetic Analysis of Tongue Size and Taste Papillae Number and Size in Recombinant Inbred Strains of Mice

2008 ◽  
Vol 33 (8) ◽  
pp. 693-707 ◽  
Author(s):  
D. J. Reiner ◽  
T. A. Jan ◽  
J. D. Boughter ◽  
C.-X. Li ◽  
L. Lu ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Inbred Strains Of Mice

Genetic analysis of barrel field size in the first somatosensory area (SI) in inbred and recombinant inbred strains of mice

2005 ◽  
Vol 22 (3) ◽  
pp. 141-150 ◽  
Author(s):  
Cheng X. Li ◽  
Xin Wei ◽  
Lu Lu ◽  
Jeremy L. Peirce ◽  
Robert W. Williams ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Field Size ◽  
Recombinant Inbred Strains ◽  
Somatosensory Area ◽  
Barrel Field ◽  
Inbred Strains Of Mice

scholarly journals Systems genetic analysis of binge-like eating in a C57BL/6J x DBA/2J-F2 cross

2020 ◽  
Author(s):  
Emily J. Yao ◽  
Richard K. Babbs ◽  
Julia C. Kelliher ◽  
Kimberly P. Luttik ◽  
M. Imad Damaj ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Binge Eating ◽  
Quantitative Trait ◽  
Recombinant Inbred ◽  
Genetic Basis ◽  
Strain Differences ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Chromosome 6 ◽  
Trait Locus

ABSTRACTObjectiveBinge eating is a heritable quantitative trait associated with eating disorders (ED) and refers to the rapid consumption of a large quantity of energy-dense food that is associated with loss of control, anxiety, and depression. Binge Eating Disorder is the most common ED in adults in the US; however, the genetic basis is unknown. We previously identified robust mouse inbred strain differences between C57BL/6J and DBA/2J in binge-like eating (BLE) of sweetened palatable food (PF) in an intermittent access, conditioned place preference paradigm.MethodsTo map the genetic basis of BLE, we phenotyped and genotyped 128 C57BL/6J x DBA/2J-F2 mice.ResultsWe identified a quantitative trait locus (QTL) on chromosome 13 influencing progressive changes in body weight across training days (LOD = 5.5; 26-39 cM). We also identified two sex-combined QTLs influencing PF intake on chromosome 5 (LOD = 5.6; 1.5-LOD interval = 21-28 cM) and 6 (LOD = 5.3; 1.5-LOD interval = 50-59 cM). Furthermore, sex-specific analyses revealed that the chromosome 6 locus was driven by males (1.5-LOD interval: 52-59 cM) and identified a female-selective QTL for BLE on chromosome 18 (LOD = 4.1; 1.5-LOD interval: 23-35 cM). Systems genetic analysis of the chromosome 6 locus for BLE using GeneNetwork legacy trait datasets from BXD recombinant inbred strains identified Adipor2 and Plxnd1 as two positional, functional, biological candidate genes.DiscussionWe identified genetic loci influencing BLE. Future studies will phenotype BXD recombinant inbred strains to fine map loci and support candidate gene nomination and validation.

Genetic analysis of graft-versus-host disease using rat recombinant inbred strains

1997 ◽  
Vol 29 (3) ◽  
pp. 1734-1735 ◽  
Author(s):  
A. Panczak ◽  
V. Bila ◽  
M. Sladka ◽  
D. Křenová ◽  
B. Otová ◽  
...  
Keyword(s):  
Genetic Analysis ◽  
Graft Versus Host Disease ◽  
Recombinant Inbred ◽  
Inbred Strains ◽  
Recombinant Inbred Strains ◽  
Host Disease ◽  
Graft Versus Host
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