Acetylcholine-induced endothelium-dependent vascular smooth muscle relaxation in nitroglycerin-tolerant isolated rat aorta

1991 ◽  
Vol 6 (3) ◽  
pp. 175-180 ◽  
Author(s):  
Atsushi Namiki ◽  
Jo Aikawa ◽  
Masao Moroi ◽  
Kiyoshi Machii ◽  
Nobuharu Akatsuka
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Rat Aorta ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation ◽  
Isolated Rat

scholarly journals Vildagliptin improves vascular smooth muscle relaxation and decreases cellular senescence in the aorta of doxorubicin-treated rats

2021 ◽  
pp. 106855
Author(s):  
Svetozár Mišúth ◽  
Marína Uhrinová ◽  
Ján Klimas ◽  
Diana Vavrincová-Yaghi ◽  
Peter Vavrinec
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Cellular Senescence ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation

Guanosine and GTP augment glyceryl trinitrate and sodium nitrite induced vascular smooth muscle relaxation and cyclic GMP accumulation

1990 ◽  
Vol 183 (4) ◽  
pp. 1272
Author(s):  
L. Pörsti ◽  
P. Vuorinen ◽  
K.E. Laustiola ◽  
T. Metsä-Ketelä ◽  
P. Arvola ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Glyceryl Trinitrate ◽  
Sodium Nitrite ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation

Interactions between nitroglycerin and endothelium in vascular smooth muscle relaxation

1991 ◽  
Vol 260 (3) ◽  
pp. H698-H701 ◽  
Author(s):  
J. L. Dinerman ◽  
D. L. Lawson ◽  
J. L. Mehta
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
No Production ◽  
Cyclic Monophosphate ◽  
The Mean ◽  
Smooth Muscle Relaxant ◽  
Vascular Smooth Muscle Relaxation

To evaluate the role of endothelium in nitroglycerin (NTG)-mediated vascular relaxation, epinephrine-contracted rat thoracic aortic segments with and without intact endothelium were exposed to NTG (10(-10) to 10(-5) M). Aortic segments with intact (endo+, n = 15) and denuded endothelium (endo-, n = 9) exhibited typical NTG-induced relaxation. However, the mean effective concentration of NTG was lower for endo- than for endo+ segments (P less than 0.001). To determine if this phenomenon related to nitric oxide (NO) generation by endothelium, six endo+ segments were treated with NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NO production. These endo+ segments exhibited greater (P less than 0.001) relaxation in response to NTG than the untreated endo+ segments. Oxyhemoglobin, an inhibitor of guanylate cyclase activation, greatly diminished NTG-mediated relaxation of all aortic segments. To determine if the enhanced NTG-mediated relaxation of endo- segments was unique to the guanosine 3',5'-cyclic monophosphate-dependent vasodilator NTG, other endo+ and endo- segments were exposed to adenosine 3',5'-cyclic monophosphate-dependent vasodilator papaverine (10(-8) to 10(-4) M), and no difference in EC50 was noted between endo+ and endo- segments. Thus endothelium attenuates NTG-mediated vasorelaxation, and this attenuation is abolished by inhibition of endothelial NO production with L-NMMA. These observations indicate that endothelium is a dynamic modulator of vascular smooth muscle relaxant effects of NTG. This modulation appears to result from a competitive interaction between endothelial NO and NTG.

CRLI induces vascular smooth muscle relaxation and suggests a dual mechanism of eNOS activation by legume lectins via muscarinic receptors and shear stress

2015 ◽  
Vol 565 ◽  
pp. 32-39 ◽  
Author(s):  
Bruno A.M. Rocha ◽  
Ito L. Barroso-Neto ◽  
Claudener S. Teixeira ◽  
Mayara Q. Santiago ◽  
Alana F. Pires ◽  
...  
Keyword(s):  
Shear Stress ◽  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscarinic Receptors ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Dual Mechanism ◽  
Legume Lectins ◽  
Vascular Smooth Muscle Relaxation

Pulmonary Vascular Smooth Muscle Relaxation by cAMP-Mediated Pathways

1996 ◽  
Vol 61 (2) ◽  
pp. 444-448 ◽  
Author(s):  
David A. Fullerton ◽  
Jeanette Agrafojo ◽  
Robert C. McIntyre, Jr.
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation

Vascular Smooth Muscle Relaxation by α-Adrenoceptor Blocking Action of Dobutamine in Isolated Rabbit Aorta

1996 ◽  
Vol 27 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Jo Aikawa ◽  
Masayuki Fukazawa ◽  
Michiro Ishikawa ◽  
Masao Moroi ◽  
Atsushi Namiki ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Rabbit Aorta ◽  
Smooth Muscle Relaxation ◽  
Isolated Rabbit Aorta ◽  
Vascular Smooth Muscle Relaxation

Investigation of terpinen-4-ol effects on vascular smooth muscle relaxation

Life Sciences ◽  
2014 ◽  
Vol 115 (1-2) ◽  
pp. 52-58 ◽  
Author(s):  
Rebeca Peres Moreno Maia-Joca ◽  
Humberto Cavalcante Joca ◽  
Francisca Jéssica Penha Ribeiro ◽  
Renata Vieira do Nascimento ◽  
Kerly Shamyra Silva-Alves ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Smooth Muscle Relaxation
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