Effect of hydrolipophilic equilibrium of the muramyl dipeptide derivatives on their internalization and interactions in biological membranes

1996 ◽  
Vol 122 (6) ◽  
pp. 1219-1221
Author(s):  
O. V. Kalyuzhin ◽  
B. B. Fuks
Keyword(s):  
Biological Membranes ◽  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives

Immunomodulating activity of new muramyl dipeptide derivatives in vitro

1992 ◽  
Vol 114 (6) ◽  
pp. 1838-1841
Author(s):  
A. �. Medvedev ◽  
B. B. Fuks ◽  
N. V. Bovin ◽  
A. E. Zemlyakov
Keyword(s):  
Muramyl Dipeptide ◽  
Immunomodulating Activity ◽  
Muramyl Dipeptide Derivatives

ChemInform Abstract: SYNTHESIS OF LIPOPHILIC MURAMYL DIPEPTIDE DERIVATIVES VIA O-AMINOACYL INTERMEDIATES

1981 ◽  
Vol 12 (4) ◽  
Author(s):  
S. KOBAYASHI ◽  
T. FUKUDA ◽  
H. YUKIMASA ◽  
I. IMADA ◽  
M. FUJINO ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives

ChemInform Abstract: MURAMYL DIPEPTIDE DERIVATIVES WITH MULTIPRENYLACETYL GROUP. SYNTHESIS AND IMMUNOLOGICAL ACTIVITIES

1982 ◽  
Vol 13 (10) ◽  
Author(s):  
T. FUKUDA ◽  
S. KOBAYASHI ◽  
H. YUKIMASA ◽  
S. TERAO ◽  
M. FUJINO ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives

Festphasensynthese von Muramyldipeptidderivaten und Untersuchung ihrer biologischen Aktivität / Solid Phase Synthesis of Muramyl Dipeptide Derivatives and Investigations on their Biological Activities

1994 ◽  
Vol 49 (5) ◽  
pp. 702-716 ◽  
Author(s):  
Jochen Tschakert ◽  
Wolfgang Voelter
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Biological Activities ◽  
Muramyl Dipeptide ◽  
Phase Synthesis ◽  
Opsonized Zymosan ◽  
Muramyl Dipeptide Derivatives

New muramyl dipeptide derivatives with exchanged carbohydrate residues are described. Each derivative is synthesized via a solid phase synthesis using an aminomethyl anchor resin. All synthetic products can be isolated in good yields. Their biological activities are tested by the luminol-dependent chemiluminescence associated with the phagocytosis of opsonized zymosan by granulocytes.

scholarly journals Synthesis of immunologically active muramyl dipeptide derivatives containing a quinonyl moiety via aminoacyl intermediates.

1981 ◽  
Vol 29 (8) ◽  
pp. 2215-2221 ◽  
Author(s):  
TSUNEHIKO FUKUDA ◽  
SHIGERU KOBAYASHI ◽  
HIDEFUMI YUKIMASA ◽  
ISUKE IMADA ◽  
MASAHIKO FUJINO ◽  
...  
Keyword(s):  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives

scholarly journals Activation of mouse peritoneal adherent cells with N-acyl muramyl dipeptide derivatives.

1985 ◽  
Vol 47 (3) ◽  
pp. 665-669 ◽  
Author(s):  
K Nishimura ◽  
H Okumura ◽  
I Saiki ◽  
H Okuyama ◽  
I Azuma
Keyword(s):  
Muramyl Dipeptide ◽  
Adherent Cells ◽  
Muramyl Dipeptide Derivatives

scholarly journals Evaluating the antibacterial activity of muramyl dipeptide derivatives, retro-tuftsin derivatives, and anthraquinone oligopeptides against a range of pathogenic bacteria

2021 ◽  
Author(s):  
Magdalena Wysocka ◽  
Krystyna Dzierzbicka ◽  
Beata Krawczyk
Keyword(s):  
Staphylococcus Aureus ◽  
Pathogenic Bacteria ◽  
Muramyl Dipeptide ◽  
Amino Acid Sequences ◽  
Microbiological Activity ◽  
Minimal Inhibitory Concentrations ◽  
Microbial Drug Resistance ◽  
Dipeptide Derivative ◽  
Muramyl Dipeptide Derivatives

Search for new and efficient antibiotic is crucial because of microbial drug resistance and problems with side effects of the administered medication. In this study, we evaluate the in vitro microbiological activity of muramyl dipeptide derivatives, retro-tuftsin derivatives (i.e., tuftsin with reversed amino acid sequences), and combinations of retro-tuftsin derivatives with substituted anthraquinones. The potency of the investigated derivatives towards methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, and Klebsiella pneumoniae ESBL (extended-spectrum β-lactamases) was compared based on the spectroscopically-measured minimal inhibitory concentrations (MIC values). The bacterial growth have also been studied with different concentrations of compounds. Statistical analysis of the results revealed that certain modifications lead to promising activity against S. aureus (anthraquinone analogue – 3c and retro-tuftsin derivative – 2b), while other derivatives exhibit activity against P. aeruginosa (muramyl dipeptide derivative – 1d and retro-tuftsin derivative – 2b). The obtained results of microbiological activity indicate that the structure of the tested compounds may be the basis for further modifications.

Effect of new muramyl dipeptide derivatives on the major components of immunity

1994 ◽  
Vol 117 (5) ◽  
pp. 508-512 ◽  
Author(s):  
O. V. Kalyuzhin ◽  
B. B. Fuks ◽  
N. V. Bovin ◽  
A. E. Zemlyakov ◽  
V. Ya. Chirva
Keyword(s):  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives

scholarly journals Enhancement of certain biological activities of muramyl dipeptide derivatives after conjugation to a multi-poly(DL-alanine)--poly(L-lysine) carrier.

1979 ◽  
Vol 76 (12) ◽  
pp. 6557-6561 ◽  
Author(s):  
L. Chedid ◽  
M. Parant ◽  
F. Parant ◽  
F. Audibert ◽  
F. Lefrancier ◽  
...  
Keyword(s):  
Biological Activities ◽  
Muramyl Dipeptide ◽  
Muramyl Dipeptide Derivatives
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