New method for the analysis of multiple positron emission tomography dynamic datasets: an example applied to the estimation of the cerebral metabolic rate of oxygen

1998 ◽  
Vol 36 (1) ◽  
pp. 83-90 ◽  
Author(s):  
D. Ho ◽  
D. Feng ◽  
K. Chen
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
New Method ◽  
Emission Tomography ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

scholarly journals Cortical Hypometabolism and its Recovery following Nucleus Basalis Lesions in Baboons: A PET Study

1987 ◽  
Vol 7 (6) ◽  
pp. 812-817 ◽  
Author(s):  
Motohiro Kiyosawa ◽  
Sabina Pappata ◽  
Danielle Duverger ◽  
Danielle Riche ◽  
Henri Cambon ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Nucleus Basalis ◽  
Emission Tomography ◽  
Metabolic Effects ◽  
Metabolic Depression ◽  
Cerebral Metabolic Rate ◽  
Positron Emission ◽  
Adaptive Mechanisms ◽  
Nucleus Basalis Lesions

The cerebral metabolic rate for glucose was measured serially with positron emission tomography and [18F]fluorodeoxyglucose in five baboons with stereotactic electrocoagulation of the left nucleus basalis of Meynert (NbM). Four days after lesion, a significant metabolic depression was present in the ipsilateral cerebral cortex, most marked in the frontotemporal region, and which recovered progressively within 6–13 weeks. These data demonstrate that adaptive mechanisms efficiently compensate for the cortical metabolic effects of NbM-lesion-induced cholinergic deafferentation. Moreover, unilateral NbM lesions also induced a transient reduction in contralateral cortical metabolic rate, the mechanisms of which are discussed. Explanation of these effects of cholinergic deafferentation in the primate could further our understanding of the metabolic deficits observed in dementia of the Alzheimer's type.

Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury

2007 ◽  
Vol 106 (4) ◽  
pp. 526-529 ◽  
Author(s):  
Michael N. Diringer ◽  
Venkatesh Aiyagari ◽  
Allyson R. Zazulia ◽  
Tom O. Videen ◽  
William J. Powers
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Oxygen Metabolism ◽  
Emission Tomography ◽  
Arterial Oxygen ◽  
Normobaric Hyperoxia ◽  
Brain Oxygen ◽  
Cerebral Metabolic Rate ◽  
Positron Emission ◽  
Brain Oxygen Metabolism

Object Recent observations indicate that traumatic brain injury (TBI) may be associated with mitochondrial dysfunction. This, along with growing use of brain tissue PO2 monitors, has led to considerable interest in the potential use of ventilation with 100% oxygen to treat patients who have suffered a TBI. To date, the impact of normobaric hyperoxia has only been evaluated using indirect measures of its impact on brain metabolism. To determine if normobaric hyperoxia improves brain oxygen metabolism following acute TBI, the authors directly measured the cerebral metabolic rate for oxygen (CMRO2) with positron emission tomography before and after ventilation with 100% oxygen. Methods Baseline measurements of arterial and jugular venous blood gases, mean arterial blood pressure, intracranial pressure, cerebral blood flow (CBF), cerebral blood volume, oxygen extraction fraction, and CMRO2 were made at baseline while the patients underwent ventilation with a fraction of inspired oxygen (FiO2) of 0.3 to 0.5. The FiO2 was then increased to 1.0, and 1 hour later all measurements were repeated. Five patients were studied a mean of 17.9 ±5.8 hours (range 12–23 hours) after trauma. The median admission Glasgow Coma Scale score was 7 (range 3–9). During ventilation with 100% oxygen, there was a marked rise in PaO2 (from 117 ± 31 to 371 ± 99 mm Hg, p < 0.0001) and a small rise in arterial oxygen content (12.7 ± 4.0 to 13.3 ± 4.6 vol %, p = 0.03). There were no significant changes in systemic hemodynamic or other blood gas measurements. At the baseline evaluation, bihemispheric CBF was 39 ± 12 ml/100 g/min and bihemispheric CMRO2 was 1.9 ± 0.6 ml/100 g/min. During hyperoxia there was no significant change in either of these measurements. (Values are given as the mean ± standard deviation throughout.) Conclusions Normobaric hyperoxia did not improve brain oxygen metabolism. In the absence of outcome data from clinical trials, these preliminary data do not support the use of 100% oxygen in patients with acute TBI, although larger confirmatory studies are needed.

scholarly journals Cerebral metabolic rate for glucose during the first six months of life: an FDG positron emission tomography study.

1996 ◽  
Vol 74 (3) ◽  
pp. F153-F157 ◽  
Author(s):  
A. Kinnala ◽  
H. Suhonen-Polvi ◽  
T. Aarimaa ◽  
P. Kero ◽  
H. Korvenranta ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Emission Tomography ◽  
Positron Emission Tomography Study ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

scholarly journals Motor dysfunction in olivopontocerebellar atrophy is related to cerebral metabolic rate studied with positron emission tomography

1988 ◽  
Vol 24 (3) ◽  
pp. 414-419 ◽  
Author(s):  
Guy Rosenthal ◽  
Sid Gilman ◽  
Robert A. Koeppe ◽  
Karen J. Kluin ◽  
Dorene S. Markel ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Motor Dysfunction ◽  
Emission Tomography ◽  
Olivopontocerebellar Atrophy ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

scholarly journals Cerebral Metabolic Rate of Glucose after Pituitary Coagulation Using Positron Emission Tomography

PAIN RESEARCH ◽  
1990 ◽  
Vol 5 (1) ◽  
pp. 69-74
Author(s):  
Keiji Ishizaki ◽  
Yasuharu Kitani ◽  
Nobuhiro Saruki ◽  
Hitoshi Shimada ◽  
Takeo Sugaya ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Emission Tomography ◽  
Cerebral Metabolic Rate ◽  
Positron Emission

scholarly journals Alteration of FHR pattern and cerebral metabolic rate of glucose of the fetus measured by positron emission tomography during progress of acidemia. The significance of overshoot acceleration in FHR

1989 ◽  
Vol 17 (4) ◽  
pp. 289-295 ◽  
Author(s):  
Kunihiro Okamura ◽  
Shingo Tanigawara ◽  
Yoshiyuki Shintaku ◽  
Takanori Watanabe ◽  
Hidetaka Endoh ◽  
...  
Keyword(s):  
Positron Emission Tomography ◽  
Metabolic Rate ◽  
Emission Tomography ◽  
Cerebral Metabolic Rate ◽  
Positron Emission
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