The results of frozen section, touch prep, and cytologic smear are comparable for intraoperative examination of sentinel lymph nodes: A prospective study in 133 consecutive breast cancer patients

2004 ◽  
Vol 11 (S2) ◽  
pp. S68-S68
Author(s):  
E. Torres-Matundan ◽  
H. Cody ◽  
L. Tan ◽  
E. Brogi
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Prospective Study ◽  
Cancer Patients ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Patients ◽  
Cytologic Smear ◽  
A Prospective Study

Frozen Sections of Sentinel Lymph Nodes From Breast Cancer Patients Who Undergo Neoadjuvant Therapy Are Accurately Diagnosed Using Telepathology

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S122-S123
Author(s):  
Valarie McMurtry ◽  
Rachel Factor
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Neoadjuvant Therapy ◽  
Cancer Patients ◽  
Treatment Effect ◽  
Frozen Section ◽  
Lobular Carcinoma ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Patients ◽  
Frozen Sections

Abstract Objectives Telepathology enables histologic diagnosis to be made from a scanned slide visualized on a computer. Frozen sections (FSs) can be performed at remote locations and read by a pathologist at a central site. At our institution, qualifying breast cancer patients are enrolled in clinical trials that require FS on sentinel lymph nodes (SLNs) after neoadjuvant therapy (NAT), including chemotherapy or endocrine therapy. In this setting, histology is complicated by treatment effect and biopsy site changes. Others have reported good accuracy of FSs on SLNs after NAT. We investigated whether pathologists are accurate in diagnosing SLN FSs for such cases while using telepathology. To our knowledge, this has not been reported previously. Methods SLNs were entirely submitted and serially sectioned (2-mm thickness). At least two levels were cut. All FSs were submitted for formalin-fixed, paraffin-embedded permanent sections. A pathology assistant at the remote location prepared the FSs and scanned slides using the VisionTek M6 digital microscope ecosystem (East Dundee, IL). Cases were interpreted by board-certified pathologists who completed training on the VisionTek system. For this study, diagnoses from FSs and permanents were compared. Results Forty-five SLNs from 19 breast neoadjuvant cases were read by VisionTek from March 2017 to January 2019. Forty-three cases (96%) called negative by FSs were confirmed negative (on permanents). One hundred percent called positive by FSs were positive. Four SLN called atypical on FSs were positive. Three of these were neoadjuvant endocrine cases for invasive lobular carcinoma. Two cases called atypical were negative. One of these, called atypical/suspicious, resulted in axillary dissection. This case was reviewed by three pathologists at the time of surgery. It had abundant treatment effect, mimicking carcinoma. Conclusion While pitfalls exist, overall, the diagnostic accuracy of frozen section analysis by telepathology of SLNs from breast cases after neoadjuvant therapy is high.

scholarly journals A prospective study comparing touch imprint cytology, frozen section analysis, and rapid cytokeratin immunostain for intraoperative evaluation of axillary sentinel lymph nodes in breast cancer

Cancer ◽  
2009 ◽  
Vol 115 (7) ◽  
pp. 1555-1562 ◽  
Author(s):  
Savitri Krishnamurthy ◽  
Funda Meric-Bernstam ◽  
Anthony Lucci ◽  
Rosa F. Hwang ◽  
Henry M. Kuerer ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Prospective Study ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Touch Imprint Cytology ◽  
Frozen Section Analysis ◽  
A Prospective Study ◽  
Section Analysis

scholarly journals Intraoperative frozen section analysis of sentinel lymph nodes in breast cancer patients

Cancer ◽  
2010 ◽  
Vol 117 (2) ◽  
pp. 250-258 ◽  
Author(s):  
Liang-Chih Liu ◽  
Julie E. Lang ◽  
Ying Lu ◽  
Denise Roe ◽  
Shelley E. Hwang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Breast Cancer Patients ◽  
Intraoperative Frozen Section ◽  
Frozen Section Analysis ◽  
Section Analysis

scholarly journals Intraoperative imprint cytology of sentinel lymph nodes in breast cancer patients: Comparation with frozen section

2020 ◽  
Vol 77 (2) ◽  
pp. 196-200
Author(s):  
Tatjana Ivkovic-Kapicl ◽  
Ferenc Vicko ◽  
Milana Panjkovic ◽  
Zoran Radovanovic ◽  
Tijana Vasiljevic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Imprint Cytology ◽  
Breast Cancer Patients ◽  
Touch Imprint Cytology

Background/Aim. Sentinel lymph node (SLN) biopsy has been established as the standard of care for axillary staging in patients with invasive breast carcinoma and clinically negative lymph nodes. Intraoperative assessment of sentinel lymph nodes might be done by frozen section (FS), touch imprint cytology (TIC) and one step nucleic acid amplification. The aim of this study was to review our institution's results with SLN biopsy using TIC and FS technique as intraoperative diagnostic tool for breast cancer patients. Methods. SLNs from 101 patients were examined intraoperatively by frozen hematoxylin-eosin (H&E) stain and by touch imprint cytology. Results of TIC were compared with FS and permanent histology sections. Results. The total number of dissected SLNs was 163 with a mean of 1.6 (1?4) per patient. The permanent H&E identified 19 (19%) patients with a sentinel lymph node metastasis and 82 (81%) patients with tumor-free sentinel nodes. The sensitivity/ specificity rates were 73.7%/99.3%, respectively for TIC and 84.2%/100%, respectively for FS. Relevant positive/ negative predictive values were 93.3%/96.6%, respectively for TIC and 100%/97.9%, respectively for FS. Conclusion. Our experience with TIC and FS for the intraoperative evaluation of SLNs is similar to the findings from previously reported studies. We detected the high specificity for both methods, but TIC technique appeared to be less sensitive than FS in detecting SLN metastases in breast cancer patients. TIC could be recommended as reasonable alternative to frozen section due to its simplicity and low cost.

Accuracy of frozen section of sentinel lymph nodes: a prospective analysis of 659 breast cancer patients of the Swiss multicenter study

2008 ◽  
Vol 113 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Igor Langer ◽  
Ulrich Guller ◽  
Gilles Berclaz ◽  
Ossi R. Koechli ◽  
Holger Moch ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Multicenter Study ◽  
Frozen Section ◽  
Sentinel Lymph Nodes ◽  
Prospective Analysis ◽  
Breast Cancer Patients

Postmastectomy hypofractionation comparison with conventional radiotherapy in breast cancer patients: A prospective study

2018 ◽  
Vol 22 (2) ◽  
pp. 71-83
Author(s):  
Asmaa Abo Agag ◽  
Mohammed S ◽  
Al Sayed Hassan ◽  
Magdy Abdel Majid ◽  
Mohmed Gaber
Keyword(s):  
Breast Cancer ◽  
Prospective Study ◽  
Cancer Patients ◽  
Breast Cancer Patients ◽  
Conventional Radiotherapy ◽  
A Prospective Study

Additional axillary metastases and stage migration in breast cancer patients with micrometastases or submicrometastases in sentinel lymph nodes

Cancer ◽  
2006 ◽  
Vol 107 (3) ◽  
pp. 467-471 ◽  
Author(s):  
Maartje C. van Rijk ◽  
Johannes L. Peterse ◽  
Omgo E. Nieweg ◽  
Hester S. A. Oldenburg ◽  
Emiel J. Th. Rutgers ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Nodes ◽  
Cancer Patients ◽  
Sentinel Lymph Nodes ◽  
Stage Migration ◽  
Breast Cancer Patients ◽  
Axillary Metastases
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