Synthesis and pharmacological evaluation of amide derivatives of non-steroidal anti-inflammatory drugs

1992 ◽  
Vol 1 (3) ◽  
pp. 201-212 ◽  
Author(s):  
M. -F. Otis ◽  
L. Levesque ◽  
F. Marceau ◽  
J. Lacroix ◽  
R. C. Gaudreault
Keyword(s):  
Pharmacological Evaluation ◽  
Amide Derivatives ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Derivatives Of

Synthesis and pharmacological evaluation of novel derivatives of anti-inflammatory drugs with increased antioxidant and anti-inflammatory activities

1999 ◽  
Vol 47 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Angeliki P. Kourounakis ◽  
Dimitrios Galanakis ◽  
Karyofillis Tsiakitzis ◽  
Eleni A. Rekka ◽  
Panos N. Kourounakis
Keyword(s):  
Pharmacological Evaluation ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Derivatives Of

Cytostatic and Antiviral Activity Evaluations of Hydroxamic Derivatives of Some Non-steroidal Anti-inflammatory Drugs

2009 ◽  
Vol 73 (3) ◽  
pp. 328-338 ◽  
Author(s):  
Zrinka Rajic ◽  
Ivan Butula ◽  
Branka Zorc ◽  
Sandra Kraljevic Pavelic ◽  
Karlo Hock ◽  
...  
Keyword(s):  
Antiviral Activity ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Derivatives Of

scholarly journals Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam

Molecules ◽  
2019 ◽  
Vol 24 (18) ◽  
pp. 3277
Author(s):  
Panagiotis Theodosis-Nobelos ◽  
Georgios Papagiouvannis ◽  
Panos N. Kourounakis ◽  
Eleni A. Rekka
Keyword(s):  
Acute Inflammation ◽  
Current Knowledge ◽  
Rat Plasma ◽  
Straightforward Method ◽  
Inflammatory Drugs ◽  
Multifunctional Agents ◽  
Anti Inflammatory ◽  
High Yields ◽  
Derivatives Of ◽  
And Oxidative Stress

Novel derivatives of some non steroidal anti-inflammatory drugs, as well as of the antioxidants α-lipoic acid, trolox and (E)-3-(3,5-di-tert-butyl-4-hydroxyphenyl)acrylic acid with lorazepam were synthesised by a straightforward method at satisfactory to high yields (40%–93%). All the tested derivatives strongly decreased lipidemic indices in rat plasma after Triton induced hyperlipidaemia. They also reduced acute inflammation and a number of them demonstrated lipoxygenase inhibitory activity. Those compounds acquiring antioxidant moiety were inhibitors of lipid peroxidation and radical scavengers. Therefore, the synthesised compounds may add to the current knowledge about multifunctional agents acting against various disorders implicating inflammation, dyslipidaemia and oxidative stress.

scholarly journals Pharmacological Evaluation and Preparation of Nonsteroidal Anti-Inflammatory Drugs Containing an N-Acyl Hydrazone Subunit

2014 ◽  
Vol 15 (4) ◽  
pp. 5821-5837 ◽  
Author(s):  
Thais de Melo ◽  
Rafael Chelucci ◽  
Maria Pires ◽  
Luiz Dutra ◽  
Karina Barbieri ◽  
...  
Keyword(s):  
Pharmacological Evaluation ◽  
Acyl Hydrazone ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Nitroxide derivatives of non-steroidal anti-inflammatory drugs exert anti-inflammatory and superoxide dismutase scavenging properties in A459 cells

2012 ◽  
Vol 165 (4b) ◽  
pp. 1058-1067 ◽  
Author(s):  
Wilmarie Flores-Santana ◽  
Terry Moody ◽  
Weibin Chen ◽  
Michael J Gorczynski ◽  
Mai E Shoman ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Derivatives Of

Amide derivatives of [6-acyl-2-benzothiazolinon-3-yl] acetic acids as potential analgesic and anti-inflammatory compounds

2009 ◽  
Vol 19 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Tijen Önkol ◽  
Erden Banoglu ◽  
Yasemin Dündar ◽  
Esra Küpeli ◽  
M. Fethi Şahin
Keyword(s):  
Amide Derivatives ◽  
Anti Inflammatory ◽  
Derivatives Of ◽  
Acetic Acids
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