T cell-derived B cell growth and differentiation factors

1987 ◽  
Vol 17 (3) ◽  
pp. 181-197
Author(s):  
Sergio Romagnani
Keyword(s):  
T Cell ◽  
Cell Growth ◽  
B Cell ◽  
Differentiation Factors ◽  
Cell Growth And Differentiation

B Cell Growth and Differentiation Factors

1984 ◽  
Vol 78 (1) ◽  
pp. 185-210 ◽  
Author(s):  
Maureen Howard ◽  
Kenji Nakanishi ◽  
WilliamE. Paul
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Differentiation Factors ◽  
Cell Growth And Differentiation

T cell replacing factor/interleukin 5 induces not only B-cell growth and differentiation, but also increased expression of interleukin 2 receptor on activated B-cells

1987 ◽  
Vol 15 (3) ◽  
pp. 205-215 ◽  
Author(s):  
Nobuyuki Harada ◽  
Mitsuhiro Matsumoto ◽  
Nobuo Koyama ◽  
Akira Shimizu ◽  
Tasuku Honjo ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Cell Growth ◽  
B Cell ◽  
Interleukin 2 ◽  
Interleukin 5 ◽  
Interleukin 2 Receptor ◽  
Cell Growth And Differentiation ◽  
Activated B Cells

B cell growth and differentiation factors interact with receptors distinct from the interleukin 2 receptor

1986 ◽  
Vol 16 (7) ◽  
pp. 761-766 ◽  
Author(s):  
John H. Kehrl ◽  
Julia H. Grove ◽  
Paul K. Goldsmith ◽  
Anthony S. Fauci
Keyword(s):  
Cell Growth ◽  
B Cell ◽  
Interleukin 2 ◽  
Interleukin 2 Receptor ◽  
Differentiation Factors ◽  
Cell Growth And Differentiation

scholarly journals T cell-derived B cell growth and differentiation factors. Dichotomy between the responsiveness of B cells from adult and neonatal mice.

1983 ◽  
Vol 157 (2) ◽  
pp. 600-612 ◽  
Author(s):  
E Pure ◽  
P C Isakson ◽  
J W Kappler ◽  
P Marrack ◽  
P H Krammer ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Cell Growth ◽  
B Cell ◽  
Immunoglobulin M ◽  
B Cell Differentiation ◽  
Neonatal Mice ◽  
Differentiation Factors ◽  
Immature B Cells ◽  
Igg Secretion

In these studies we have determined the molecular weights of B cell growth factor (BCGF) (less than 20,000), and B cell differentiation factors (BCDF) that induce immunoglobulin M (IgM) secretion (BCDF mu) (30-60,000) and IgG secretion (BCDF gamma) (less than 20,000). Thus, the molecular weight of BCDF mu is distinct from that of BCGF and BCDF gamma; BCGF and BCDF gamma cannot be distinguished. In addition, BCGF, BCDF mu, and BCDF gamma are distinguishable by their presence or absence in different supernatants from a panel of mitogen-induced T cell clones. These results suggest that the three lymphokines are different. This conclusion is supported by their differential biological effect on B cells from adult and neonatal mice. Thus, treatment with anti-Ig induces B cells from adult mice to proliferate and this proliferation is sustained by BCGF. In contrast, even in the presence of BCGF, anti-Ig does not induce B cells from neonatal mice to proliferate. However, BCDF mu and BCDF gamma induce IgM and IgG secretion in B cells, respectively, from both adult and neonatal mice. Thus, mature B cells can both clonally expand and differentiate in response to anti-Ig, BCGF, and BCDF, whereas immature B cells can only differentiate. The poor response of neonatal B cells to anti-Ig and BCGF may partially explain the relative immunoincompetence of immature B cells.

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