Adjuvant effect ofBacillus firmus in intranasal immunization of guinea pigs with inactivated type B influenza virus

2006 ◽  
Vol 51 (2) ◽  
pp. 154-156 ◽  
Author(s):  
M. Havlíčková ◽  
L. Prokešová ◽  
P. Zanvit ◽  
J. Táčner ◽  
R. Limberková





1947 ◽  
Vol 85 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Thomas Francis

Preparations of Type B influenza virus, propagated in the embryonated egg and obtained in the form of allantoic fluid, were found after heating at 56°C. for 30 minutes to retain the capacity to agglutinate erythrocytes but no longer measured specific antibody when used as antigen in titrations of serum antibody. The dissociation of the two activities suggests the presence in such virus preparations of a complex virus antigen comprising, (1) a heat-stable component which agglutinates erythrocytes and reacts primarily with specific antibody; (2) a heat-labile component reacting with a factor of normal serum which ordinarily tends to inhibit the hemagglutinating activity of influenza virus. The relation of the reagents to other known serological activities of influenza virus is being studied.







2004 ◽  
Vol 1263 ◽  
pp. 350-354 ◽  
Author(s):  
Suset Oropesa ◽  
P Lago ◽  
A Goyenechea ◽  
B Hernández ◽  
M Bello ◽  
...  




2002 ◽  
Vol 37 (2) ◽  
pp. 101-105 ◽  
Author(s):  
Yukiharu Hayase ◽  
Kiyotake Tobita ◽  
Hiroyuki Sato


1947 ◽  
Vol 25e (4) ◽  
pp. 181-187 ◽  
Author(s):  
Christine E. Rice

When Types A and B Clostridium botulinum toxoids were mixed the resultant divalent toxoid was found to have a very high protective potency against both Type A and Type B botulinus toxin. The resistance to Type A toxin induced in guinea-pigs and mice by the divalent toxoid mixture was only slightly less than that conferred by a similar volume of univalent Type A toxoid. Guinea-pigs given the divalent toxoid developed a comparable or slightly higher degree of immunity to Type B toxin than those injected with univalent Type B toxoid.Although no evidence of reciprocal protection had been observed between Type A and Type B toxoids, admixture with Type A toxoid appreciably increased the antigenicity of the Type B toxoid for mice. Mice immunized with the divalent, A + B, toxoid exhibited a higher level of resistance to Type B toxin than those given the same number of doses of Type B toxoid alone. No adjuvant effect was noted on mixing Type A or Type B botulinus toxoids with tetanus or diphtheria toxoids.



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