Chronic treatment with a long-acting somatostatin analogue in a patient with intestinal carcinoid tumor: occurence of cholelithiasis

AbstractWe are reporting a case of 68-year-old woman with insulinoma, after a non-successful tumor surgery and a long-term diazoxide treatment. She had a lot of hypoglycemia cases, and a weight gain of 50 kg. An abdominal CT scan demonstrated a tumor 28 mm in the diameter, in the head of the pancreas. The patient did not agree for the repeated insulinoma surgery. Furthermore, we found a lesion in the left adrenal gland (14 mm in the diameter) and in the right lung (8 mm in the diameter). Pheochromocytoma was diagnosed on the basis of hypertension, elevated levels of normetanephrine in the 24-h urine collection, and an elevated level of norepinephrine in a plasma sample. After the left adrenal gland removal we observed lower blood pressure. Since we had revealed the presence of somatostatin receptors by the somatostatin receptors scintigraphy, we decided to control hypoglycemia by a monthly subcutaneous administration of the long-acting lanreotide. Because of higher glucose levels (300–400 mg/dl) we started an intense insulin therapy. Nowadays, the patient feels better, she has lost 20 kg of her body weight, and we have observed normal blood glucose levels during the long-term lanreotide treatment. We have noticed neither side effects nor hypoglycemic episodes and we have reduced the dose of insulin. The presented case can be an evidence of the effective treatment of the pancreatic neuroendocrine tumor of insulinoma type, with somatostatin analogue.

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Effect of Octreotide, a Long-Acting Somatostatin Analogue, on Plasma Amino Acid Uptake by the Pancreas

Pancreas ◽

10.1097/00006676-199111000-00008 ◽

1991 ◽

Vol 6 (6) ◽

pp. 668-672 ◽

Cited By ~ 10

Author(s):

L. Gullo ◽

R. Pezzilli ◽

Dvora Ancona ◽

A. Morselli Labate ◽

L. Barbara

Keyword(s):

Amino Acid ◽

Amino Acid Uptake ◽

Plasma Amino Acid ◽

Somatostatin Analogue ◽

Acid Uptake ◽

Long Acting

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Long-Acting Somatostatin Analogue Safety Monitoring Protocol for Outpatients With Neuroendocrine Tumors

Journal of the Advanced Practitioner in Oncology ◽

10.6004/jadpro.2019.10.7.2 ◽

2019 ◽

Vol 10 (7) ◽

Author(s):

Jordan Gabrielsen, PharmD ◽

Gianna Girone, PharmD ◽

Bonita Bennett, BSN ◽

Anna Jung, PharmD, BCPS

Keyword(s):

Neuroendocrine Tumors ◽

Safety Monitoring ◽

Somatostatin Analogue ◽

Monitoring Protocol ◽

Long Acting

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Short-term recovery of visual field loss in acromegaly during treatment with a long-acting somatostatin analogue

The American Journal of Medicine ◽

10.1016/0002-9343(89)90359-8 ◽

1989 ◽

Vol 86 (4) ◽

pp. 496-498 ◽

Cited By ~ 4

Author(s):

William E. Cobb ◽

Ivor M.D. Jackson

Keyword(s):

Visual Field ◽

Visual Field Loss ◽

Somatostatin Analogue ◽

Short Term ◽

Long Acting

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Somatostatin and gastrointestinal tract. Clinical experiences

Orvosi Hetilap ◽

10.1556/oh.2013.29721 ◽

2013 ◽

Vol 154 (39) ◽

pp. 1535-1540 ◽

Cited By ~ 3

Author(s):

László Herszényi ◽

Emese Mihály ◽

Zsolt Tulassay

Keyword(s):

Gastrointestinal Tract ◽

Gastrointestinal Hormones ◽

Gastrointestinal Diseases ◽

Somatostatin Analogues ◽

Therapeutic Modality ◽

Exocrine Function ◽

Somatostatin Analogue ◽

Clinical Experiences ◽

Pancreatic Fistulas ◽

Long Acting

The effect of somatostatin on the gastrointestinal tract is complex; it inhibits the release of gastrointestinal hormones, the exocrine function of the stomach, pancreas and bile, decreases motility and influences absorption as well. Based on these diverse effects there was an increased expectation towards the success of somatostatin therapy in various gastrointestinal disorders. The preconditions for somatostatin treatment was created by the development of long acting somatostatin analogues (octreotide, lanreotide). During the last twenty-five years large trials clarified the role of somatostatin analogues in the treatment of various gastrointestinal diseases. This study summarizes shortly these results. Somatostatin analogue treatment could be effective in various pathological conditions of the gastrointestinal tract, however, this therapeutic modality became a part of the clinical routine only in neuroendocrine tumours and adjuvant treatment of oesophageal variceal bleeding and pancreatic fistulas. Orv. Hetil., 2013, 154, 1535–1540.

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