Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty

2008 ◽  
Vol 31 (9) ◽  
pp. 839-840 ◽  
Author(s):  
M. F. Messina ◽  
T. Arrigo ◽  
M. Wasniewska ◽  
F. Lombardo ◽  
G. Crisafulli ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Cyproterone Acetate ◽  
Combined Treatment ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Peripheral Precocious Puberty ◽  
Mccune Albright

scholarly journals Combined treatment with bicalutamide and anastrozole in a young boy with peripheral precocious puberty due to McCune-Albright Syndrome

2012 ◽  
Vol 59 (2) ◽  
pp. 111-117 ◽  
Author(s):  
Daniele Tessaris ◽  
Patrizia Matarazzo ◽  
Alessandro Mussa ◽  
Gerdi Tuli ◽  
Francesca Verna ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Combined Treatment ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Peripheral Precocious Puberty ◽  
Mccune Albright

scholarly journals Adult height following a combined treatment of ketoconazole - cyproterone acetate - leuprolide depot in a boy with atypical McCune-Albright syndrome

HORMONES ◽  
2014 ◽  
Author(s):  
Maria Francesca Messina ◽  
Tommaso Aversa ◽  
Luisa de Sanctis ◽  
Malgorzata Wasniewska ◽  
Mariella Valenzise ◽  
...  
Keyword(s):  
Cyproterone Acetate ◽  
Adult Height ◽  
Combined Treatment ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Mccune Albright

scholarly journals Pathophysiology of Peripheral Precocious Puberty in girls: an overview

2021 ◽  
Vol 1 (4) ◽  
Author(s):  
Konstantina Toutoudaki ◽  
George Paltoglou ◽  
Eleni Paschalidou ◽  
Ermioni Tsrana ◽  
Panagiotis Christopoulos
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Precocious Puberty ◽  
Adrenal Hyperplasia ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Peripheral Precocious Puberty ◽  
Mccune Albright

Precocious puberty can be distinguished in central, or peripheral, based on the presence or absence of the Hypothalamic- Pituitary- Gonadal axis activation. The pathogenesis of peripheral precocious puberty (PPP) is based mainly on excessive estrogenic exposure, either endogenous or exogenous. The congenital causes of PPP include McCune- Albright syndrome (MAS) and Congenital Adrenal Hyperplasia (CAH). The main causes of acquired PPP are oestrogen producing tumours, which are mainly of ovarian or adrenal origin, hypothyroidism and environmental oestrogens or substances with estrogenic function.

scholarly journals MON-247 Clinical Characterization of Female Peripheral Precocious Puberty Due to McCune-Albright Syndrome

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Aline Faria ◽  
Ana Canton ◽  
Carolina Ramos ◽  
Carlos Seraphim ◽  
Berenice Mendonca ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Peripheral Precocious Puberty ◽  
Mccune Albright

scholarly journals Treatment of precocious puberty in a McCune–Albright syndrome patient using Chinese medicinal herbs combined with megestrol acetate: A case report

2018 ◽  
Vol 01 (01) ◽  
pp. 69-74
Author(s):  
Wen Sun ◽  
Yonghong Wang ◽  
Jian Yu ◽  
Min Ji
Keyword(s):  
Precocious Puberty ◽  
Bone Dysplasia ◽  
Medicinal Herbs ◽  
Megestrol Acetate ◽  
Chinese Medicinal Herbs ◽  
Gene Encoding ◽  
Mccune Albright Syndrome ◽  
Activating Mutation ◽  
Albright Syndrome ◽  
Mccune Albright

Introduction: McCune–Albright Syndrome (MAS) is a rare congenital sporadic disorder characterized by fibrous bone dysplasia, café-au-lait pigmented spots on the skin, and non-gonadotropin dependent precocious puberty (PP), which is caused by a postzygotic somatic activating mutation in the GNAS gene encoding the alpha subunit of Gs protein. In our case study, we recorded a girl with the onset of MAS and treated her with Chinese medicinal herbs combined with megestrol acetate. We aim to provide a method for the treatment of children with this rare form of precocious puberty. Case Presention: A 4-year-old girl presented with vaginal bleeding and enlarged breasts. The activating mutation of GNAS was not detected in the patient’s peripheral blood samples, as some had reported. Because of peripheral PP and fibrous dysplasia of the diagnosed bone, the patient was considered as MAS. We chose the Chinese medicinal herbs combined with megestrol acetate for treatment, and the patient was effectively treated. Conclusion: The combination therapy of Chinese medicinal herbs plus megestrol acetate in managing PP in an MAS is one of the useful treatments.

scholarly journals McCune Albright Syndrome: A Case Report

2020 ◽  
Vol 40 (2) ◽  
pp. 134-137
Author(s):  
Subhana Thapa Karki ◽  
Vandana Jain
Keyword(s):  
Case Report ◽  
Fibrous Dysplasia ◽  
Precocious Puberty ◽  
Genetic Disease ◽  
Clinical Presentation ◽  
Endocrine Disorders ◽  
Mccune Albright Syndrome ◽  
Café Au Lait Spots ◽  
Albright Syndrome ◽  
Mccune Albright

McCune Albright syndrome (MAS) is a very rare genetic disease characterised by any two of the following three findings: café au lait spots, polyosteotic fibrous dysplasia and endocrine disorders. The clinical presentation of MAS may vary depending on which of the various components of the syndrome predominate. Here, we report one case of MAS presenting with precocious puberty.

scholarly journals MECHANISM OF PRECOCIOUS PUBERTY IN GIRLS WITH McCUNE-ALBRIGHT SYNDROME (MAS)

1984 ◽  
Vol 18 ◽  
pp. 167A-167A
Author(s):  
Carol M Foster ◽  
Ora H Pescovitz ◽  
Thomas H Shawker ◽  
Judith L Ross ◽  
Gordon B Cutler ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Mccune Albright Syndrome ◽  
Albright Syndrome ◽  
Mccune Albright

Diagnosis and Management of Precocious Puberty in Atypical Presentations of McCune-Albright Syndrome: A Case Series Review

2012 ◽  
Vol 25 (1) ◽  
pp. e9-e13 ◽  
Author(s):  
Jennifer L. Bercaw-Pratt ◽  
Tracy Patel Moorjani ◽  
Xiomara M. Santos ◽  
Lefkothea Karaviti ◽  
Jennifer E. Dietrich
Keyword(s):  
Precocious Puberty ◽  
Case Series ◽  
Mccune Albright Syndrome ◽  
Diagnosis And Management ◽  
Albright Syndrome ◽  
Atypical Presentations ◽  
Mccune Albright
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