Inhibitors of adrenal cortical function

2007 ◽  
pp. 114-172 ◽  
Author(s):  
Robert Gaunt ◽  
J. J. Chart ◽  
A. A. Renzi
Keyword(s):  
Cortical Function ◽  
Adrenal Cortical Function

SALT LOAD AND ADRENAL CORTICAL FUNCTION IN HYPERTENSION

1960 ◽  
Vol 34 (1_Suppla) ◽  
pp. S169-S194
Author(s):  
W. A. J. Crane
Keyword(s):  
Cortical Function ◽  
Salt Load ◽  
Adrenal Cortical Function

Evaluation of Adrenal Cortical Function in Neonatal and Weanling Laboratory Beagle Dogs

2021 ◽  
pp. 019262332110094
Author(s):  
Janet M. Petruska ◽  
Maria Adamo ◽  
Jeffrey McCartney ◽  
Ahamat Aboulmali ◽  
Thomas J. Rosol
Keyword(s):  
Adrenal Gland ◽  
Pituitary Gland ◽  
Endocrine System ◽  
Beagle Dogs ◽  
Cortical Function ◽  
Test Species ◽  
Toxicity Studies ◽  
Gland Function ◽  
Common Target ◽  
Adrenal Cortical Function

The most common target organ for toxicity in the endocrine system is the adrenal gland, and its function is dependent upon the hypothalamus and pituitary gland. Histopathologic examination of the adrenal glands and pituitary gland is routinely performed in toxicity studies. However, the function of the adrenal gland is not routinely assessed in toxicity studies. Assessment of adrenal cortical function may be necessary to determine whether a histopathologic finding in the adrenal cortex results in a functional effect in the test species. As juvenile toxicity studies are more commonly performed in support of pediatric indications for pharmaceuticals, it is important to establish historical control data for adrenal gland function. In this study, adrenal cortical function was assessed in control neonatal and weanling beagle dogs as part of an ongoing juvenile toxicology program. Measurements of serum adrenocorticotropic hormone (ACTH), cortisol prior to and following administration of exogenous ACTH, and aldosterone were conducted beginning at 2 weeks of age continuing through 26 weeks of age. Serum electrolyte concentrations were determined at 4, 13, and 26 weeks of age. Dogs as young as 2 weeks of age synthesize and secrete adrenal cortical hormones and exhibit a functional hypothalamic pituitary adrenal axis.

scholarly journals THE NEUTRAL LIPIDE-SOLUBLE REDUCING SUBSTANCES OF URINE AS AN INDEX OF ADRENAL CORTICAL FUNCTION

1946 ◽  
Vol 165 (2) ◽  
pp. 699-710 ◽  
Author(s):  
R.D.H. Heard ◽  
H. Sobel ◽  
Eleanor H. Venning
Keyword(s):  
Cortical Function ◽  
Reducing Substances ◽  
Adrenal Cortical Function

Adrenal cortical function in essential hypertension; study of the eosinophil response to epinephrine

1950 ◽  
Vol 9 (2) ◽  
pp. 259
Author(s):  
Harold Joseph ◽  
John Binion ◽  
Louis Tobian
Keyword(s):  
Essential Hypertension ◽  
Cortical Function ◽  
Adrenal Cortical Function

scholarly journals Relation of Adrenal Cortical Function to Scurvy in Guinea-pigs

BMJ ◽  
1951 ◽  
Vol 2 (4737) ◽  
pp. 927-930 ◽  
Author(s):  
B. E. Clayton ◽  
F. T. G. Prunty
Keyword(s):  
Guinea Pigs ◽  
Cortical Function ◽  
Adrenal Cortical Function

scholarly journals ADRENAL CORTICAL FUNCTION IN PATIENTS WITH TETANUS

1970 ◽  
Vol 42 (6) ◽  
pp. 531-534 ◽  
Author(s):  
M.J. LEVELL ◽  
S.R. STITCH ◽  
J.R.W. DYKES ◽  
J.J.L. ABLETT
Keyword(s):  
Cortical Function ◽  
Adrenal Cortical Function

Physiology and Tests of Adrenal Cortical Function

2009 ◽  
Author(s):  
Wendy J. Schillings
Keyword(s):  
Cortical Function ◽  
Adrenal Cortical Function
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