Analysis of the Cluster of Ribosomal Protein Genes in the Plastid Genome of a Unicellular Red Alga Cyanidioschyzon merolae: Translocation of the str Cluster as an Early Event in the Rhodophyte-Chromophyte Lineage of Plastid Evolution

1997 ◽  
Vol 45 (6) ◽  
pp. 688-695 ◽  
Author(s):  
Niji Ohta ◽  
Naoki Sato ◽  
Hisayoshi Nozaki ◽  
Tsuneyoshi Kuroiwa
Keyword(s):  
Ribosomal Protein ◽  
Plastid Genome ◽  
Red Alga ◽  
Early Event ◽  
Cyanidioschyzon Merolae ◽  
Ribosomal Protein Genes ◽  
Plastid Evolution

Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein

1991 ◽  
Vol 11 (8) ◽  
pp. 3842-3849
Author(s):  
K Pogue-Geile ◽  
J R Geiser ◽  
M Shu ◽  
C Miller ◽  
I G Wool ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Cdna Clone ◽  
Ribosomal Proteins ◽  
Human Colon ◽  
Early Event ◽  
Normal Colonic Mucosa ◽  
Colorectal Tumors ◽  
Ribosomal Protein Genes ◽  
Normal Human ◽  
Adenocarcinoma Of The Colon

We have isolated a cDNA clone encoding the human S3 ribosomal protein from a normal human colon cDNA library. The clone was identified as one of many that detected genes whose level of expression was increased in adenocarcinoma of the colon relative to normal colonic mucosa. Increased levels of the S3 transcript were present in the tumors of all eight patients examined. Moreover, the S3 mRNA was also more abundant in 7 of 10 adenomatous polyps, the presumed precursor of carcinoma. Additional studies demonstrated that increased levels of mRNAs encoding several other ribosomal proteins, including S6, S8, S12, L5, and P0, were present in colorectal tumors and polyps. These results suggest that there is increased synthesis of ribosomes in colorectal tumors and that this increase is an early event in colon neoplasia.

scholarly journals Ribosomal protein genes are overexpressed in colorectal cancer: isolation of a cDNA clone encoding the human S3 ribosomal protein.

1991 ◽  
Vol 11 (8) ◽  
pp. 3842-3849 ◽  
Author(s):  
K Pogue-Geile ◽  
J R Geiser ◽  
M Shu ◽  
C Miller ◽  
I G Wool ◽  
...  
Keyword(s):  
Ribosomal Protein ◽  
Cdna Clone ◽  
Ribosomal Proteins ◽  
Human Colon ◽  
Early Event ◽  
Normal Colonic Mucosa ◽  
Colorectal Tumors ◽  
Ribosomal Protein Genes ◽  
Normal Human ◽  
Adenocarcinoma Of The Colon

We have isolated a cDNA clone encoding the human S3 ribosomal protein from a normal human colon cDNA library. The clone was identified as one of many that detected genes whose level of expression was increased in adenocarcinoma of the colon relative to normal colonic mucosa. Increased levels of the S3 transcript were present in the tumors of all eight patients examined. Moreover, the S3 mRNA was also more abundant in 7 of 10 adenomatous polyps, the presumed precursor of carcinoma. Additional studies demonstrated that increased levels of mRNAs encoding several other ribosomal proteins, including S6, S8, S12, L5, and P0, were present in colorectal tumors and polyps. These results suggest that there is increased synthesis of ribosomes in colorectal tumors and that this increase is an early event in colon neoplasia.

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