Inhibitory effect of baicalin on allergic response in ovalbumin-induced allergic rhinitis guinea pigs and lipopolysaccharide-stimulated human mast cells

2016 ◽  
Vol 65 (8) ◽  
pp. 603-612 ◽  
Author(s):  
Yun-jiang Zhou ◽  
Hu Wang ◽  
He-huan Sui ◽  
Li Li ◽  
Chun-ling Zhou ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Guinea Pigs ◽  
Inhibitory Effect ◽  
Allergic Response ◽  
Human Mast Cells

Mast Cell-Mediated Allergic Response Is Suppressed by Sophorae Flos: Inhibition of Src-Family Kinase

2008 ◽  
Vol 233 (10) ◽  
pp. 1271-1279 ◽  
Author(s):  
Jun Ho Lee ◽  
Jie Wan Kim ◽  
Na Young Ko ◽  
Se Hwan Mun ◽  
Do Kyun Kim ◽  
...  
Keyword(s):  
Mast Cells ◽  
Map Kinases ◽  
Herbal Medicines ◽  
Inhibitory Effect ◽  
Allergic Response ◽  
Src Family Kinase ◽  
Potent Effect ◽  
Alternative Medicines ◽  
Ige Mediated

Complementary and alternative medicines are considered as a promising direction for the development of anti-allergic therapies in oriental countries. We screened approximately 100 oriental herbal medicines for anti-allergic activity. Sophorae flos exhibited the most potent effect on degranulation in antigen-stimulated mast cells. We further investigated the effect of Sophorae flos on the IgE-mediated allergic response in vivo and its mechanism of action in mast cells. Sophorae flos exhibited a significant inhibitory effect on degranulation in antigen-stimulated mast cells with IC50 values of ~31.6 μg/mL (RBL-2H3 mast cells) and ~47.8 μg/mL (bone marrow-derived mast cells). Sophorae flos also suppressed the expression and secretion of TNF-α and IL-4 in the cells and IgE-mediated passive cutaneous anaphylaxis (PCA) in mice. Sophorae flos inhibited the activating phosphorylation of Syk and LAT in mast cells. Further downstream, activating phosphorylation of Akt and the prototypic MAP kinases, namely, p38, ERK1/2, and JNK, were also inhibited. These results suggest that Sophorae flos inhibits the Src family kinase-dependent signaling cascades in mast cells and may thus exert anti-allergic activity.

scholarly journals The inhibitory effect of TMK-688 on experimental allergic rhinitis in guinea pigs.

1993 ◽  
Vol 61 ◽  
pp. 80
Author(s):  
Takashi Shizawa ◽  
Kenichi Abe ◽  
Kazuha Maeda ◽  
Ryohei Yanoshita ◽  
Yoshiyasu Sobukawa
Keyword(s):  
Allergic Rhinitis ◽  
Guinea Pigs ◽  
Inhibitory Effect ◽  
Experimental Allergic

IL-33 mediated amplification of allergic response in human mast cells

2019 ◽  
Vol 39 (4) ◽  
pp. 359-367 ◽  
Author(s):  
Shahana Parveen ◽  
Dhivya Bharathi Saravanan ◽  
Rohit Saluja ◽  
Berla Thangam Elden
Keyword(s):  
Mast Cells ◽  
Allergic Response ◽  
Human Mast Cells

scholarly journals Antiallergic effect of Gami-hyunggyeyeongyotang on ovalbumin-induced allergic rhinitis in mouse and human mast cells

2016 ◽  
Vol 79 (4) ◽  
pp. 185-194 ◽  
Author(s):  
Yong-Seok Im ◽  
Bina Lee ◽  
Eun-Young Kim ◽  
Ju-Hee Min ◽  
Dea-Uk Song ◽  
...  
Keyword(s):  
Allergic Rhinitis ◽  
Mast Cells ◽  
Human Mast Cells ◽  
Antiallergic Effect

Inhibition of Human and Animal Platelet Adhesiveness to Glass Bead Columns by Adenosine, Dipyridamole, Chlorpromazine and Acetylsalicylic Acid

1976 ◽  
Vol 36 (02) ◽  
pp. 401-410 ◽  
Author(s):  
Buichi Fujttani ◽  
Toshimichi Tsuboi ◽  
Kazuko Takeno ◽  
Kouichi Yoshida ◽  
Masanao Shimizu
Keyword(s):  
Guinea Pig ◽  
Acetylsalicylic Acid ◽  
Guinea Pigs ◽  
Glass Bead ◽  
Animal Species ◽  
Inhibitory Effect ◽  
Rabbit Platelet ◽  
Platelet Adhesiveness

SummaryThe differences among human, rabbit and guinea-pig platelet adhesiveness as for inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid are described, and the influence of measurement conditions on platelet adhesiveness is also reported. Platelet adhesiveness of human and animal species decreased with an increase of heparin concentrations and an increase of flow rate of blood passing through a glass bead column. Human and rabbit platelet adhesiveness was inhibited in vitro by adenosine, dipyridamole and chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig platelet adhesiveness was inhibited by the four drugs including acetylsalicylic acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the inhibitory effect in guinea-pigs, but not in rabbits.

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