Glial versus melanocyte cell fate choice: Schwann cell precursors as a cellular origin of melanocytes

2010 ◽  
Vol 67 (18) ◽  
pp. 3037-3055 ◽  
Author(s):  
Igor Adameyko ◽  
Francois Lallemend
Keyword(s):  
Schwann Cell ◽  
Cell Fate ◽  
Cellular Origin ◽  
Schwann Cell Precursors

scholarly journals Schwann Cell Precursors from Nerve Innervation Are a Cellular Origin of Melanocytes in Skin

Cell ◽  
2009 ◽  
Vol 139 (2) ◽  
pp. 366-379 ◽  
Author(s):  
Igor Adameyko ◽  
Francois Lallemend ◽  
Jorge B. Aquino ◽  
Jorge A. Pereira ◽  
Piotr Topilko ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Cellular Origin ◽  
Schwann Cell Precursors

scholarly journals Stabilization of β-catenin promotes melanocyte specification at the expense of the Schwann cell lineage

2020 ◽  
Author(s):  
Sophie Colombo ◽  
Valérie Petit ◽  
Roselyne Y Wagner ◽  
Delphine Champeval ◽  
Ichiro Yajima ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Schwann Cells ◽  
Cell Fate ◽  
Active Form ◽  
Cell Lineage ◽  
Cell Fate Decisions ◽  
Schwann Cell Development ◽  
Summary Statement ◽  
Schwann Cell Precursors ◽  
Canonical Wnt

AbstractThe canonical Wnt/β-catenin pathway governs a multitude of developmental processes in various cell lineages, including the melanocyte lineage. Indeed, β-catenin regulates Mitf-M transcription, the master regulator of this lineage. The first wave of melanocytes to colonize the skin is directly derived from neural crest cells, while a small number of second wave melanocytes is derived from Schwann-cell precursors (SCPs). We investigated the influence of β-catenin in the development of melanocytes of the first and second waves by generating mice expressing a constitutively active form of β-catenin in cells expressing tyrosinase. Constitutive activation of β-catenin did not affect the development of truncal melanoblasts, but led to a marked hyperpigmentation of the paws. By activating β-catenin at various stages of development (E8.5-E11.5), we showed that the activation of β-catenin in bipotent SCPs favored melanoblast specification at the expense of Schwann cells in the limbs within a specific temporal window. In addition, hyperactivation of the Wnt/β-catenin pathway repressed FoxD3 expression, which is necessary for Schwann cell development, through Mitf-M activation. In conclusion, β-catenin overexpression promotes SCP cell-fate decisions towards the melanocyte lineage.Summary statementActivation of β-catenin in bipotent Schwann-cell precursors during a specific developmental window, induces MITF and represses FoxD3 to promote melanoblast cell fate at the expense of Schwann cells in limbs.

scholarly journals Malignant Schwann cell precursors mediate intratumoral plasticity in human neuroblastoma

2020 ◽  
Author(s):  
Thale K. Olsen ◽  
Jörg Otte ◽  
Shenglin Mei ◽  
Polina Kameneva ◽  
Åsa Björklund ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Cell Fate ◽  
Normal Development ◽  
Therapeutic Resistance ◽  
Malignant Cells ◽  
Cell Fate Decision ◽  
Human Neuroblastoma ◽  
Schwann Cell Precursors ◽  
Fate Decision ◽  
A Minor

AbstractNeuroblastoma is a heterogeneous embryonal malignancy and the most deadly tumor of childhood, although a minor subset may show spontaneous differentiation. It arises from the multipotent neural crest lineage during development. Some of this multipotency is retained in neuroblastoma, which can give rise to both adrenergic and mesenchymal tumor cells. The mechanisms enabling such dual fates are unknown, but likely help neuroblastoma to evade existing therapies. To understand neuroblastoma plasticity, we analyzed patient tumors using single-cell transcriptomics. In addition to the heterogeneous adrenergic and mesenchymal populations, we identify a subpopulation of malignant cells resembling Schwann cell precursors (SCPs). This SCP-like population connects the adrenergic and mesenchymal compartments through transitions structurally reminiscent of the SCP cell-fate decision fork that occurs during normal development. While the directionality of such transitions in neuroblastoma remains to be established, this finding expands the potential reservoirs of malignant cells, and suggests intratumoral plasticity mechanisms relevant for therapeutic resistance and relapse.

scholarly journals Nerve-associated Schwann cell precursors contribute extracutaneous melanocytes to the heart, inner ear, supraorbital locations and brain meninges

2021 ◽  
Author(s):  
Marketa Kaucka ◽  
Bara Szarowska ◽  
Michaela Kavkova ◽  
Maria Eleni Kastriti ◽  
Polina Kameneva ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Inner Ear ◽  
Gene Knockout ◽  
Hair Follicles ◽  
Lineage Tracing ◽  
Pigment Cells ◽  
Hearing Function ◽  
Embryonic Origin ◽  
Schwann Cell Precursors ◽  
Evolutionary Aspects

AbstractMelanocytes are pigmented cells residing mostly in the skin and hair follicles of vertebrates, where they contribute to colouration and protection against UV-B radiation. However, the spectrum of their functions reaches far beyond that. For instance, these pigment-producing cells are found inside the inner ear, where they contribute to the hearing function, and in the heart, where they are involved in the electrical conductivity and support the stiffness of cardiac valves. The embryonic origin of such extracutaneous melanocytes is not clear. We took advantage of lineage-tracing experiments combined with 3D visualizations and gene knockout strategies to address this long-standing question. We revealed that Schwann cell precursors are recruited from the local innervation during embryonic development and give rise to extracutaneous melanocytes in the heart, brain meninges, inner ear, and other locations. In embryos with a knockout of the EdnrB receptor, a condition imitating Waardenburg syndrome, we observed only nerve-associated melanoblasts, which failed to detach from the nerves and to enter the inner ear. Finally, we looked into the evolutionary aspects of extracutaneous melanocytes and found that pigment cells are associated mainly with nerves and blood vessels in amphibians and fish. This new knowledge of the nerve-dependent origin of extracutaneous pigment cells might be directly relevant to the formation of extracutaneous melanoma in humans.

Schwann cell precursors generate sympathoadrenal system during zebrafish development

2021 ◽  
Author(s):  
Dmitrii Kamenev ◽  
Kazunori Sunadome ◽  
Maxim Shirokov ◽  
Andrey S. Chagin ◽  
Ajeet Singh ◽  
...  
Keyword(s):  
Schwann Cell ◽  
Sympathoadrenal System ◽  
Zebrafish Development ◽  
Schwann Cell Precursors

Schwann cell precursors and their development

Glia ◽  
1991 ◽  
Vol 4 (2) ◽  
pp. 185-194 ◽  
Author(s):  
Kristjan R. Jessen ◽  
Rhona Mirsky
Keyword(s):  
Schwann Cell ◽  
Schwann Cell Precursors

scholarly journals Genetic Events and Signaling Mechanisms Underlying Schwann Cell Fate in Development and Cancer

Neurosurgery ◽  
2020 ◽  
Author(s):  
Harish N Vasudevan ◽  
Calixto-Hope G Lucas ◽  
Javier E Villanueva-Meyer ◽  
Philip V Theodosopoulos ◽  
David R Raleigh
Keyword(s):  
Schwann Cell ◽  
Cell Fate ◽  
Cell Development ◽  
Nerve Sheath Tumor ◽  
Cell Lineages ◽  
Nerve Sheath ◽  
Signaling Mechanisms ◽  
Schwann Cell Development ◽  
Novel Therapeutic Strategies ◽  
Genetic Events

Abstract In this review, we describe Schwann cell development from embryonic neural crest cells to terminally differentiated myelinated and nonmyelinated mature Schwann cells. We focus on the genetic drivers and signaling mechanisms mediating decisions to proliferate versus differentiate during Schwann cell development, highlighting pathways that overlap with Schwann cell development and are dysregulated in tumorigenesis. We conclude by considering how our knowledge of the events underlying Schwann cell development and mouse models of schwannoma, neurofibroma, and malignant peripheral nerve sheath tumor can inform novel therapeutic strategies for patients with cancers derived from Schwann cell lineages.

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