Synthesis, anti-inflammatory and anticancer activity evaluation of some mono- and bis-Schiff’s bases

2011 ◽  
Vol 21 (11) ◽  
pp. 3620-3628 ◽  
Author(s):  
Sham M. Sondhi ◽  
Surbhi Arya ◽  
Reshma Rani ◽  
Nikhil Kumar ◽  
Partha Roy
Keyword(s):  
Anticancer Activity ◽  
Schiff’S Bases ◽  
Activity Evaluation ◽  
Schiff's Bases ◽  
Anti Inflammatory

Synthesis, anti-inflammatory and anticancer activity evaluation of some novel acridine derivatives

2010 ◽  
Vol 45 (2) ◽  
pp. 555-563 ◽  
Author(s):  
Sham M. Sondhi ◽  
Jaiveer Singh ◽  
Reshma Rani ◽  
P.P. Gupta ◽  
S.K. Agrawal ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Acridine Derivatives ◽  
Activity Evaluation ◽  
Anti Inflammatory

Design, Synthesis, Antioxidant and Anticancer Activity of Novel Schiff’s Bases of 2-Amino Benzothiazole

2018 ◽  
Vol 52 (4s) ◽  
pp. S333-S342 ◽  
Author(s):  
Saipriya Saipriya D ◽  
Arun Prakash ◽  
Suvarna G Kini ◽  
Varadaraj Bhatt G ◽  
K Sreedhara Ranganath Pai ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Schiff’S Bases ◽  
Design Synthesis ◽  
Schiff's Bases

Synthesis, anti-inflammatory, and anticancer activity evaluation of some heterocyclic amidine and bis-amidine derivatives

2011 ◽  
Vol 48 (4) ◽  
pp. 921-926 ◽  
Author(s):  
Sham M. Sondhi ◽  
Reshma Rani ◽  
Partha Roy ◽  
S. K. Agrawal ◽  
A. K. Saxena
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation ◽  
Anti Inflammatory

Synthesis, analgesic, anti-inflammatory and anti-ulcerogenic activities of certain novel Schiff’s bases as fenamate isosteres

2015 ◽  
Vol 25 (2) ◽  
pp. 179-183 ◽  
Author(s):  
Ahmed M. Alafeefy ◽  
Mohammed A. Bakht ◽  
Majid A. Ganaie ◽  
Mohd N. Ansarie ◽  
Nahed N. El-Sayed ◽  
...  
Keyword(s):  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Anti Inflammatory

Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives

2010 ◽  
Vol 20 (7) ◽  
pp. 2306-2310 ◽  
Author(s):  
Sham M. Sondhi ◽  
Reshma Rani ◽  
Jaiveer Singh ◽  
Partha Roy ◽  
S.K. Agrawal ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Solvent Free ◽  
Benzimidazole Derivatives ◽  
Activity Evaluation ◽  
Anti Inflammatory ◽  
Solvent Free Synthesis

Synthesis anti-inflammatory and anticancer activity evaluation of some pyrazole and oxadiazole derivatives

2011 ◽  
Vol 21 (10) ◽  
pp. 3043-3052 ◽  
Author(s):  
Sham M. Sondhi ◽  
Sandeep Kumar ◽  
Nikhil Kumar ◽  
Partha Roy
Keyword(s):  
Anticancer Activity ◽  
Activity Evaluation ◽  
Oxadiazole Derivatives ◽  
Anti Inflammatory

Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

2019 ◽  
Vol 16 (3) ◽  
pp. 249-255
Author(s):  
Momin Khan ◽  
Umar Ali ◽  
Anis Ur Rahman ◽  
Muhammad Ibrahim ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Ferrous Ion ◽  
Future Research ◽  
Scavenging Activity ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. </P><P> Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. </P><P> Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 &#177; 4.75 &#181;M) which has slightly low activity than the standard EDTA (IC50 = 318.40 &#177; 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 &#177; 4.60 &#181;M). </P><P> Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

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