Design, Synthesis, Antioxidant and Anticancer Activity of Novel Schiff’s Bases of 2-Amino Benzothiazole

2018 ◽  
Vol 52 (4s) ◽  
pp. S333-S342 ◽  
Author(s):  
Saipriya Saipriya D ◽  
Arun Prakash ◽  
Suvarna G Kini ◽  
Varadaraj Bhatt G ◽  
K Sreedhara Ranganath Pai ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Schiff’S Bases ◽  
Design Synthesis ◽  
Schiff's Bases

Synthesis, anti-inflammatory and anticancer activity evaluation of some mono- and bis-Schiff’s bases

2011 ◽  
Vol 21 (11) ◽  
pp. 3620-3628 ◽  
Author(s):  
Sham M. Sondhi ◽  
Surbhi Arya ◽  
Reshma Rani ◽  
Nikhil Kumar ◽  
Partha Roy
Keyword(s):  
Anticancer Activity ◽  
Schiff’S Bases ◽  
Activity Evaluation ◽  
Schiff's Bases ◽  
Anti Inflammatory

NOVEL SCHIFF'S BASES OF SUBSTITUTED 2-AMINO BENZOTHIAZOLES: DESIGN, SYNTHESIS AND ANTIMICROBIAL ACTIVITY

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (04) ◽  
pp. 18-26
Author(s):  
D. Sai Priya ◽  
◽  
S. G Kini ◽  
V. G Bhatt ◽  
E Rathi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Docking Study ◽  
Single Step ◽  
Mass Spectrometry Data ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Schiff’S Bases ◽  
Molecular Docking Study ◽  
Design Synthesis ◽  
Schiff's Bases

Novel Schiff’s bases bearing substituted 2-amino benzothiazole were synthesized by single step process through simple condensation of 2-amino benzothiazole and substituted benzaldehydes and further characterized by FTIR, 1HNMR, and Mass spectrometry data. Antimicrobial activity of compounds was performed by agar diffusion method against a panel of bacterial strains such as S. aureus, B. subtilis (Gram-positive bacteria), E. coli, P. aeruginosa (Gram-negative bacteria) and fungal strains such as C. albicans and A. niger. Compound S13 and S17 had shown potent antifungal activity against C. albicans and A. niger respectively among the novel Schiff’s base compounds when compared to standard, and S13 compound had only shown moderate antibacterial activity against S. aureus amongst all. Molecular docking study was carried out against C. albicans DHFR (Dihydrofolate Reductase) domain to confirm their activity.

scholarly journals Design, Synthesis of a Novel Banana-Shaped Compounds via Esterification

2021 ◽  
Vol 17 (4) ◽  
pp. 81-92
Author(s):  
Omar Mahdi ◽  
Hanaa Salih ◽  
Abdullah Kshash
Keyword(s):  
Benzoic Acid ◽  
Absolute Ethanol ◽  
Schiff’S Bases ◽  
Melting Points ◽  
Design Synthesis ◽  
Schiff's Bases ◽  
Amino Phenol ◽  
Ft Ir ◽  
Amino Benzoic Acid

Schiff's Bases were synthesized from the reaction of p-amino benzoic acid and alkoxybenzaldehyde in absolute ethanol and reacted with (E)-3-((4-hydroxybenzylidene) amino) phenol used DCC (N,N'-Dicyclocarbodiimide) and DAMP (4-(Dimethylamino) pyridine ) to 3-(((E)-4-((4-(((E)-4 alkoxy benzylidene) amino) benzoyl) oxy) benzylidene) amino) phenyl4- (E)- 4-alkoxy benzyli dene ) amino) benzoate. The structures of the products were confirmed by their melting points, FT-IR, 1HNMR spectra.

Design, Synthesis and In Vitro Evaluation of 18β-Glycyrrhetinic Acid Derivatives for Anticancer Activity Against Human Breast Cancer Cell Line MCF-7

2014 ◽  
Vol 21 (9) ◽  
pp. 1160-1170 ◽  
Author(s):  
Dharmendra Yadav ◽  
Komal Kalani ◽  
Abhishek Singh ◽  
Feroz Khan ◽  
Santosh Srivastava ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Anticancer Activity ◽  
Breast Cancer Cell Line ◽  
Human Breast Cancer ◽  
Cancer Cell Line ◽  
Human Breast Cancer Cell ◽  
Human Breast ◽  
Design Synthesis ◽  
Mcf 7

Green Synthesis, Characterization, DPPH and Ferrous Ion-chelating (FIC) Activity of Tetrakis-Schiff’s Bases of Terephthalaldehyde

2019 ◽  
Vol 16 (3) ◽  
pp. 249-255
Author(s):  
Momin Khan ◽  
Umar Ali ◽  
Anis Ur Rahman ◽  
Muhammad Ibrahim ◽  
Abdul Hameed ◽  
...  
Keyword(s):  
Antioxidant Activities ◽  
Radical Scavenging Activity ◽  
Radical Scavenging ◽  
Aromatic Aldehydes ◽  
Ferrous Ion ◽  
Future Research ◽  
Scavenging Activity ◽  
Schiff’S Bases ◽  
Schiff's Bases ◽  
Antioxidant Agents

Background: The role of small molecules as antioxidants to prevent the oxidation of other molecules and inhibit them from radical formation is the area of much interest to cure disease especially cancer. Moreover, the antioxidants play important role as stabilizers to prevent oxidation of fuels and lubricants. </P><P> Methods: In the present study, fifteen tetrakis-Schiff’s bases derivatives (1-15) were synthesized and screened for their antioxidant activities. Compounds 1-15 were synthesized by continuous stirring of reaction mixture of 1,4-bis (hydrazonomethyl)benzene (1 mmol) with various substituted aromatic aldehydes (2 mmol) in distilled water using acetic acid as catalyst at room temperature for 2-10 min. </P><P> Results: Our present study showed that all compounds are better ferrous ion-chelating agents except compound 1,4-bis((E)-((E)-(3,4-dimethoxybenzylidene)hydrazono)methyl)benzene (6) (IC50 = 329.26 &#177; 4.75 &#181;M) which has slightly low activity than the standard EDTA (IC50 = 318.40 &#177; 5.53 μM). In addition, DPPH radical scavenging activity of eleven compounds showed higher activity than the standard. However, remaining four compounds showed comparable radical scavenging activity to the standard DPPH (IC50 = 257.77 &#177; 4.60 &#181;M). </P><P> Conclusion: The series of fifteen Schiff’s bases (1-15) were synthesized and evaluated as antioxidants. From both assays, it has been demonstrated that most of the tetrakis-Schiff’s bases have potential to serve as leads for the development of antioxidant agents for future research.

Synthesis of Schiff's bases Derived from 2- Amino - 1,3,4- Thiadiazole and 1,3,4- Oxadiazole with Naphthaldehydes

2006 ◽  
Vol 9 (1) ◽  
pp. 21-28
Author(s):  
Emaad . T. bakir Al-Takrity ◽  
◽  
Ibtisam K. Jassim ◽  
Wissam K. Jassim ◽  
◽  
...  
Keyword(s):  
Schiff’S Bases ◽  
Schiff's Bases

EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives

Life Sciences ◽  
2021 ◽  
Vol 277 ◽  
pp. 119531
Author(s):  
Ahmed A.E. Mourad ◽  
N.A. Farouk ◽  
El-Sherbiny H. El-Sayed ◽  
Ahmed R.E. Mahdy
Keyword(s):  
Anticancer Activity ◽  
Docking Study ◽  
Dual Inhibitor ◽  
Design Synthesis

Design, synthesis and biological assessment of novel CDK4 inhibitor with potent anticancer activity

2021 ◽  
Vol 109 ◽  
pp. 104717
Author(s):  
Yongtao Li ◽  
Renle Du ◽  
Yongwei Nie ◽  
Tianqi Wang ◽  
Yakun Ma ◽  
...  
Keyword(s):  
Anticancer Activity ◽  
Biological Assessment ◽  
Design Synthesis ◽  
Cdk4 Inhibitor

Design, synthesis, anticancer activity, and in silico studies of novel imidazo[1,2‐ a ]pyridine based 1 H ‐1,2,3‐triazole derivatives

2021 ◽  
Author(s):  
Srinivas Endoori ◽  
Kali Charan Gulipalli ◽  
Srinu Bodige ◽  
Parameshwar Ravula ◽  
Nareshvarma Seelam
Keyword(s):  
Anticancer Activity ◽  
In Silico ◽  
Design Synthesis ◽  
Triazole Derivatives ◽  
In Silico Studies
Sign in / Sign up

Export Citation Format

Share Document