Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats

2004 ◽  
Vol 369 (2) ◽  
pp. 166-178 ◽  
Author(s):  
K. M. Ellis ◽  
C. Cannet ◽  
L. Mazzoni ◽  
J. R. Fozard
Keyword(s):  
Airway Hyperresponsiveness ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats

2001 ◽  
Vol 132 (7) ◽  
pp. 1509-1523 ◽  
Author(s):  
J P Hannon ◽  
B Tigani ◽  
I Williams ◽  
L Mazzoni ◽  
J R Fozard
Keyword(s):  
Airway Hyperresponsiveness ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Norway Rats

Effect of interleukin-1β on airway hyperresponsiveness and inflammation in sensitized and nonsensitized Brown-Norway rats

1994 ◽  
Vol 93 (2) ◽  
pp. 464-469 ◽  
Author(s):  
Hideo Tsukagoshi ◽  
Tatsuo Sakamoto ◽  
Wenbing Xu ◽  
Peter J. Barnes ◽  
K.Fan Chung
Keyword(s):  
Airway Hyperresponsiveness ◽  
Interleukin 1Β ◽  
Brown Norway ◽  
Norway Rats

scholarly journals Airway hyperresponsiveness to adenosine induced by lipopolysaccharide in Brown Norway rats

2002 ◽  
Vol 136 (1) ◽  
pp. 111-119 ◽  
Author(s):  
B Tigani ◽  
J. P. Hannon ◽  
C. Rondeau ◽  
L. Mazzoni ◽  
J. R. Fozard
Keyword(s):  
Airway Hyperresponsiveness ◽  
Brown Norway ◽  
Norway Rats

Effects of erlotinib on pulmonary function and airway remodeling after sensitization and repeated allergen challenge in Brown-Norway rats

2011 ◽  
Vol 175 (3) ◽  
pp. 349-356 ◽  
Author(s):  
Yu-Chung Kung ◽  
Ching-Chi Lin ◽  
Shwu-Fang Liaw ◽  
Mei-Wei Lin ◽  
Feng-Ting Chang
Keyword(s):  
Pulmonary Function ◽  
Airway Remodeling ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Norway Rats

Allergen-induced airway hyperresponsiveness in Brown-Norway rat: role of parasympathetic mechanisms

1993 ◽  
Vol 75 (1) ◽  
pp. 279-284 ◽  
Author(s):  
W. Elwood ◽  
T. Sakamoto ◽  
P. J. Barnes ◽  
K. F. Chung
Keyword(s):  
Airway Hyperresponsiveness ◽  
Allergen Challenge ◽  
Electrical Field Stimulation ◽  
Airway Responsiveness ◽  
Brown Norway ◽  
Field Stimulation ◽  
Electrical Field ◽  
Norway Rat

Enhanced parasympathetic mechanisms may contribute to airway hyperresponsiveness. The present study examined whether the in vivo increase in airway responsiveness seen 18–24 h after either a single or chronic aerosolized allergen challenge protocol in actively sensitized Brown-Norway rats was due to altered parasympathetic mechanisms. The roles of central and reflex vagal mechanisms were studied by performing bilateral cervical vagotomy before measurement of airway responsiveness. Bilateral vagotomy failed to reduce the increase in airway responsiveness after either a single or chronic allergen challenge. The roles of increased neural release of acetylcholine (ACh) and increased end organ responsiveness were studied in vitro. The isometric responses of tracheal and bronchial strips to both electrical field stimulation and exogenously applied ACh from rats exposed both to single and chronic allergen challenges were compared with those from saline-exposed rats. The responses to electrical field stimulation and to exogenous ACh were not significantly enhanced 18–24 h after either protocol. We conclude that the airway hyperresponsiveness observed in this allergic rat model is not mediated through an enhancement of parasympathetic mechanisms.

scholarly journals Effects of Zileuton on Airway Smooth Muscle Remodeling after Repeated Allergen Challenge in Brown Norway Rats

Respiration ◽  
2013 ◽  
Vol 86 (5) ◽  
pp. 421-429 ◽  
Author(s):  
Wei-Ji Chen ◽  
Shwu-Fang Liaw ◽  
Ching-Chi Lin ◽  
Mei-Wei Lin ◽  
Feng-Ting Chang
Keyword(s):  
Smooth Muscle ◽  
Airway Smooth Muscle ◽  
Allergen Challenge ◽  
Brown Norway ◽  
Norway Rats ◽  
Muscle Remodeling
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