Ikarisoside A inhibits acetylcholine-induced catecholamine secretion and synthesis by suppressing nicotinic acetylcholine receptor-ion channels in cultured bovine adrenal medullary cells

2015 ◽  
Vol 388 (12) ◽  
pp. 1259-1269 ◽  
Author(s):  
Xiaojia Li ◽  
Yumiko Toyohira ◽  
Takafumi Horisita ◽  
Noriaki Satoh ◽  
Keita Takahashi ◽  
...  
Keyword(s):  
Ion Channels ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Catecholamine Secretion ◽  
Nicotinic Acetylcholine ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

Inhibition by carbamazepine of various ion channels-mediated catecholamine secretion in cultured bovine adrenal medullary cells

1995 ◽  
Vol 352 (3) ◽  
Author(s):  
Reiji Yoshimura ◽  
Nobuyuki Yanagihara ◽  
Takeshi Terao ◽  
Kouichiro Minami ◽  
Kazuhiko Abe ◽  
...  
Keyword(s):  
Ion Channels ◽  
Catecholamine Secretion ◽  
Adrenal Medullary Cells ◽  
Medullary Cells

The α7 Nicotinic Acetylcholine Receptor Subunit Exists in Two Isoforms that Contribute to Functional Ligand-Gated Ion Channels

2004 ◽  
Vol 66 (3) ◽  
pp. 420-429 ◽  
Author(s):  
Emily G. Severance ◽  
Hongling Zhang ◽  
Yolmari Cruz ◽  
Sergei Pakhlevaniants ◽  
Stephen H. Hadley ◽  
...  
Keyword(s):  
Ion Channels ◽  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Receptor Subunit ◽  
Α7 Nicotinic Acetylcholine Receptor ◽  
Nicotinic Acetylcholine ◽  
Gated Ion Channels ◽  
Ligand Gated Ion Channels

scholarly journals A Variant in the Nicotinic Acetylcholine Receptor Alpha 3 Subunit Gene Is Associated With Hypertension Risks in Hypogonadic Patients

2020 ◽  
Vol 11 ◽  
Author(s):  
Tao Wu ◽  
Yujia Wang ◽  
Wei Shi ◽  
Bi-Qi Zhang ◽  
John Raelson ◽  
...  
Keyword(s):  
Acetylcholine Receptor ◽  
Nicotinic Acetylcholine Receptor ◽  
Chromaffin Cells ◽  
Gene Knockout ◽  
Catecholamine Secretion ◽  
Study Cohort ◽  
Subunit Gene ◽  
Nicotinic Acetylcholine ◽  
Human Genetic Study ◽  
Human And Mouse

Ephb6 gene knockout causes hypertension in castrated mice. EPHB6 controls catecholamine secretion by adrenal gland chromaffin cells (AGCCs) in a testosterone-dependent way. Nicotinic acetylcholine receptor (nAChR) is a ligand-gated Ca2+/Na+ channel, and its opening is the first signaling event leading to catecholamine secretion by AGCCs. There is a possibility that nAChR might be involved in EPHB6 signaling, and thus sequence variants of its subunit genes are associated with hypertension risks. CHRNA3 is the major subunit of nAChR used in human and mouse AGCCs. We conducted a human genetic study to assess the association of CHRNA3 variants with hypertension risks in hypogonadic males. The study cohort included 1,500 hypogonadic Chinese males with (750 patients) or without (750 patients) hypertension. The result revealed that SNV rs3743076 in the fourth intron of CHRNA3 was significantly associated with hypertension risks in the hypogonadic males. We further showed that EPHB6 physically interacted with CHRNA3 in AGCCs, providing a molecular basis for nAChR being in the EPHB6 signaling pathway.

scholarly journals Effects of sea urchin toxin on catecholamine secretion and ion channels in cultured bovine adrenal medullary cells.

1993 ◽  
Vol 61 ◽  
pp. 294
Author(s):  
Hideyuki Nakagawa ◽  
Nobuyuki Yanagihara ◽  
Futoshi Izumi ◽  
Akihiko Wada ◽  
Akira Kimura
Keyword(s):  
Ion Channels ◽  
Sea Urchin ◽  
Catecholamine Secretion ◽  
Adrenal Medullary Cells ◽  
Medullary Cells
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