scholarly journals Reduction in phencyclidine induced sensorimotor gating deficits in the rat following increased system xc − activity in the medial prefrontal cortex

2012 ◽  
Vol 226 (3) ◽  
pp. 531-540 ◽  
Author(s):  
Victoria Lutgen ◽  
Krista Qualmann ◽  
Jon Resch ◽  
Linghai Kong ◽  
SuJean Choi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating

P.3.d.019 Vabicaserin: effects of a novel 5-HT2C agonist on medial prefrontal cortex neurotransmission, cognition and sensorimotor gating

2007 ◽  
Vol 17 ◽  
pp. S484 ◽  
Author(s):  
S. Rosenzweig-Lipson ◽  
C.E. Beyer ◽  
Z. Hughes ◽  
Q. Lin ◽  
M.Y. Zhang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating

scholarly journals Recurrent Moderate Hypoglycemia Suppresses Brain-Derived Neurotrophic Factor Expression in the Prefrontal Cortex and Impairs Sensorimotor Gating in the Posthypoglycemic Period in Young Rats

2016 ◽  
Vol 38 (1) ◽  
pp. 74-82 ◽  
Author(s):  
Raghavendra Rao ◽  
Kathleen Ennis ◽  
Eugena P. Mitchell ◽  
Phu V. Tran ◽  
Jonathan C. Gewirtz
Keyword(s):  
Prefrontal Cortex ◽  
Prepulse Inhibition ◽  
Medial Prefrontal Cortex ◽  
Neurotrophic Factor ◽  
Sensorimotor Gating ◽  
Neuronal Injury ◽  
Brain Derived Neurotrophic Factor ◽  
Acoustic Startle Reflex ◽  
Fear Potentiated Startle ◽  
Recurrent Hypoglycemia

Recurrent hypoglycemia is common in infants and children. In developing rat models, recurrent moderate hypoglycemia leads to neuronal injury in the medial prefrontal cortex. To understand the effects beyond neuronal injury, 3-week-old male rats were subjected to 5 episodes of moderate hypoglycemia (blood glucose concentration, approx. 30 mg/dl for 90 min) once daily from postnatal day 24 to 28. Neuronal injury was determined using Fluoro-Jade B histochemistry on postnatal day 29. The effects on brain-derived neurotrophic factor (BDNF) and its cognate receptor, tyrosine kinase receptor B (TrkB) expression, which is critical for prefrontal cortex development, were determined on postnatal day 29 and at adulthood. The effects on prefrontal cortex-mediated function were determined by assessing the prepulse inhibition of the acoustic startle reflex on postnatal day 29 and 2 weeks later, and by testing for fear-potentiated startle at adulthood. Recurrent hypoglycemia led to neuronal injury confined primarily to the medial prefrontal cortex. BDNF/TrkB expression in the prefrontal cortex was suppressed on postnatal day 29 and was accompanied by lower prepulse inhibition, suggesting impaired sensorimotor gating. Following the cessation of recurrent hypoglycemia, the prepulse inhibition had recovered at 2 weeks. BDNF/TrkB expression in the prefrontal cortex had normalized and fear-potentiated startle was intact at adulthood. Recurrent moderate hypoglycemia during development has significant adverse effects on the prefrontal cortex in the posthypoglycemic period.

Neuronal coding of auditory sensorimotor gating in medial prefrontal cortex

2017 ◽  
Vol 326 ◽  
pp. 200-208 ◽  
Author(s):  
Attila Tóth ◽  
Zoltán Petykó ◽  
Rita Gálosi ◽  
Imre Szabó ◽  
Kázmér Karádi ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating ◽  
Neuronal Coding

Knockdown of mortalin within the medial prefrontal cortex impairs normal sensorimotor gating

Synapse ◽  
2010 ◽  
Vol 64 (11) ◽  
pp. 808-813 ◽  
Author(s):  
Nicole Gabriele ◽  
Giuseppe F. Pontoriero ◽  
Nancy Thomas ◽  
Shazli K. Shethwala ◽  
Zdenek B. Pristupa ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating

Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats

1995 ◽  
Vol 122 (1) ◽  
pp. 27-34 ◽  
Author(s):  
N. R. Swerdlow ◽  
D. L. Braff ◽  
M. A. Geyer ◽  
B. K. Lipska ◽  
D. R. Weinberger ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating ◽  
Ventral Hippocampus ◽  
Adult Rats ◽  
Increased Sensitivity

scholarly journals Schizophrenia-like reduced sensorimotor gating in intact inbred and outbred rats is associated with decreased medial prefrontal cortex activity and volume

2019 ◽  
Vol 44 (11) ◽  
pp. 1975-1984 ◽  
Author(s):  
Carles Tapias-Espinosa ◽  
Cristóbal Río-Álamos ◽  
Ana Sánchez-González ◽  
Ignasi Oliveras ◽  
Daniel Sampedro-Viana ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Medial Prefrontal Cortex ◽  
Sensorimotor Gating
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