Square-wave adsorptive cathodic stripping voltammetric determination of anti-inflammatory indomethacin drug in tablets and human serum at a mercury electrode

Flutamide is a nonsteriodal anti-androgen drug, which is commonly used in the treatment of advanced prostate cancer. Based on the reduction of the nitro organic moiety of the drug molecule in acetate buffer of pH 5 at the hanging mercury drop electrode, three adsorptive cathodic stripping voltammetric procedures were optimized for determination of flutamide in bulk, tablets, and human serum applying linear-sweep, differential-pulse, and square-wave waveforms. The achieved limits of detection of the bulk drug were 1.9 × 107, 8.7 × 108, and 9.7 × 109 mol L1 by using the optimized differential-pulse, linear-sweep, and square-wave adsorptive stripping voltammetric procedures, respectively. Repeatability of the results was studied for 1 × 106 mol L1 of the drug and the recoveries obtained were 98.51 ± 1.56% (LSV), 98.89 ± 0.87% (DPV), and 99.21 ± 1.03% (SWV). The proposed procedures were successfully applied to the determination of the drug in pharmaceutical formulation (Eulexin® tablets) and human serum. The detection limits of the drug in bulk, pharmaceutical formulation, and human serum achieved by means of the proposed procedures showed that the square-wave mode was more reliable for determination of the drug especially in its low concentration levels.Key words: flutamide, linear-sweep, differential-pulse, square-wave, cathodic adsorptive stripping voltammetry, determination, Eulexin® tablets, human serum.

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Cathodic stripping voltammetric determination of selenium(IV) at a thin-film mercury electrode in a thiocyanate-containing electrolyte

Fresenius Journal of Analytical Chemistry ◽

10.1007/s002160050500 ◽

1997 ◽

Vol 358 (6) ◽

pp. 736-740 ◽

Cited By ~ 15

Author(s):

Britta Lange ◽

F. Scholz

Keyword(s):

Thin Film ◽

Mercury Electrode ◽

Voltammetric Determination ◽

Cathodic Stripping

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Electrochemical determination of muscle relaxant drug tetrazepam in bulk form, pharmaceutical formulation, and human serum

Chemical Papers ◽

10.2478/s11696-008-0001-7 ◽

2008 ◽

Vol 62 (2) ◽

Cited By ~ 6

Author(s):

Mohammed Ghoneim ◽

Hanaa El-Desoky ◽

Mohammed El-Ries ◽

Ashraf Abd-Elaziz

Keyword(s):

Human Serum ◽

Mercury Electrode ◽

Stripping Voltammetry ◽

Differential Pulse ◽

Electrochemical Determination ◽

Differential Pulse Polarography ◽

Linear Sweep ◽

Square Wave ◽

Cathodic Stripping Voltammetry ◽

Cathodic Stripping

AbstractTetrazepam dissolved in the Britton-Robinson universal buffer of various pH values (2.5–11.5) containing 10 vol. % of ethanol was reduced at the mercury electrode in a single 2-electron irreversible step due to reduction of the 4,5 C=N double bond of the seven-membered ring. Differential pulse polarography (DPP) and adsorptive cathodic stripping voltammetry (AdCSV) techniques (Linear sweep LS, differential pulse DP and square-wave SW modes) for quantification of tetrazepam in bulk form and in myolastan tablets are presented. Moreover, the described linear sweep, differential pulse, and square-wave adsorptive cathodic stripping voltammetry was successfully applied in quantification of tetrazepam in spiked human serum without any prior extraction of the drug. The obtained results showed an increased sensitivity of the described electro-analytical procedures for the quantification of tetrazepam in the following order DPP, DP-AdCSV, LS-AdCSV, and SW-AdCSV, since the observed limits of tetrazepam quantitation by these electroanalytical techniques were 5 × 10−6 mol L−1, 3 × 10−7 mol L−1, 1 × 10−8 mol L−1, and 3 × 10−9 mol L−1, respectively.

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